J Korean Endocr Soc.  2008 Aug;23(4):253-259.

Determinants of the Brachial-Ankle Pulse Wave Velocity (baPWV) in Patients with Type 2 Diabetes Mellitus

• Lee SW
• Yun KW
• Yu YS
• Lim HK
• Bae YP
• Lee BD
• Kim BH
• Lee CW

Abstract

BACKGROUND
Pulse wave velocity (PWV) correlates with arterial distensibility and stiffness and is a useful method for evaluating the severity of systemic atherosclerosis in adults. Brachial-ankle PWV (baPWV) is affected by many different factors such as age, systolic blood pressure (SBP), sex, body mass index, waist to hip ratio, and HbA1c. We evaluated the determinants of baPWV in patients with type 2 diabetes mellitus. METHODS: The study included 803 type 2 diabetic patients over age 30 who had their ankle brachial pressure index (ABI) and baPWV measured at Busan St. Mary's Medical Center, Busan, Korea. Anthropometric parameters, blood pressure, pulse pressure, fasting plasma glucose, fasting insulin, HbA1c, lipid profile, high sensitivity C-reactive protein (hs-CRP), and microalbuminuria were checked concurrently. We also investigated tobacco and alcohol use by means of questionnaire. We then retrospectively analyzed the relationships between baPWV and various risk factors. RESULTS: Differences between men and women were measured using the independence sample probate. Pearson correlation analysis confirmed the factors affecting the baPWV as follows: SBP, diastolic blood pressure, pulse pressure, age, waist circumference, gender, and duration of diabetes mellitus were positively correlated, and height and weight were negatively correlated. On aged-adjusted partial correlation, HbA1c, SBP, diastolic blood pressure, and pulse pressure were correlated. By multiple linear regression analysis, SBP, age, HbA1c, and weight were independent predictors of baPWV. CONCLUSION: The baPWV is principally affected by SBP and age in patients with type 2 diabetes mellitus.

Keyword

atherosclerosis; pulse wave velocity; type 2 diabetes mellitus

MeSH Terms

Adult
Animals
Ankle
Atherosclerosis
Blood Pressure
Body Mass Index
C-Reactive Protein
Diabetes Mellitus
Diabetes Mellitus, Type 2
Fasting
Female
Glucose
Humans
Insulin
Korea
Linear Models
Male
Plasma
Pulse Wave Analysis
Surveys and Questionnaires
Retrospective Studies
Risk Factors
Tobacco
Waist Circumference
Waist-Hip Ratio
C-Reactive Protein
Glucose
Insulin

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