Korean J Med.  2011 Jan;80(1):31-35.

Clinical Significance of Nighttime Blood Pressure

Affiliations
  • 1Cardiovascular Center, Department of Internal Medicine, Ewha Womens University Mokdong Hospital, Ewha Womens University School of Medicine, Seoul, Korea.

Abstract

It was impossible to measure the nighttime blood pressure in patients with hypertension for more than one hundred years. The introduction of ambulatory blood pressure monitoring made it possible to evaluate the nighttime blood pressure and clinical significances in recent 40 years. There are tremendous evidences for proving that the nighttime blood pressure is the more powerful predictor in cardiovascular morbidity and mortality than conventional office and ambulatory daytime blood pressure. The cardiovascular mortality can be reduced when 5% of nighttime blood pressure decreased from Ohasama registry report. So investigators should reevaluate the antihypertensive drugs in the view points of nighttime blood pressure reduction. And changing the administration schedule of antihypertensive drugs, so called chronotherapy, is effective for controlling the nighttime blood pressure and modifying the blood pressure circadian rhythm. Korean Ambulatory Blood Pressure (KORABP), nationwide ambulatory blood pressure monitoring registry in Korea, may answer unproved questions for controlling nighttime blood pressure.

Keyword

Hypertension; Non-dipper; Nighttime; Chronotherapy

MeSH Terms

Antihypertensive Agents
Appointments and Schedules
Blood Pressure
Blood Pressure Monitoring, Ambulatory
Chronotherapy
Circadian Rhythm
Humans
Hypertension
Korea
Research Personnel
Antihypertensive Agents
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