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Effects of sodium vanadate on contractility of vascular smooth muscle

Yoon YK, Moon CH, Lee YH, Kang BS, Kang DH

The present study was intended to examine the effect of sodium vanadate on contractility of vascular smooth muscle. Aortic ring preparations were made from the rabbit thoracic aorta and endothelial...
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The effects of changes in intracellular Ca2+ activity of osteoblast-like cell on fracture healing

Min BH, Park SR, Kim YB, Suh CK, Kim NH

Bone formation by osteoblast may be closely related to the increase in intracellular Ca2+ activity of osteoblast. In order to study the effects of changes in Ca2+ activity of osteoblast-like...
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The effect of sodium fluoride and sodium orthovanadate on osteoblastic cell line MC3T3-E1 cells

Kim WJ, Chung KR

  • KMID: 2271229
  • Korean J Orthod.
  • 1991 Mar;21(1):97-111.
It is the aim of this study to investigate the effects of sodium fluoride and sodium orthovanadate upon the proliferation and activity of the osteoblast (MC3T3-E1 cells). MC3T3-E1 cells were...
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Effects of Vanadate and Pervanadate on Contraction of Cat Gastric Smooth Muscle

Sim SS, Choi HB, Shim HS, Rhie DJ, Hahn SJ, Yoon SH, Kim MS, Jo YH

  • KMID: 2084877
  • Korean J Gastroenterol.
  • 1999 Jan;33(1):1-10.
BACKGROUND/AIMS: Activated mammalian cells produce the reactive oxygen species from oxygen and they convert vanadate into pervanadate. The aim of the present study was to compare the contactile mechanisms of...
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Effects of Ca2+ Antagonists and Protein Kinase Inhibitors on Ethanol-Induced Contraction of Cat Gastric Smooth Muscle

Sim SS, Choi JC, Kim MS, Kim CJ, Jo YH

  • KMID: 2240323
  • Korean J Gastroenterol.
  • 2000 May;35(5):539-545.
BACKGROUND/AIMS: The mechanism of ethanol in contraction of gastric smooth muscle still remains unclear. To investigate underlying mechanism of ethanol in tonic contraction, we measured isometric contractions of cat gastric smooth muscle using...
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Effects of Vanadate on the Contractility of Vascular Smooth Muscle

Song GH, Ahn DS, Chung HJ, Kang BS

Vanadate is a trace element in animal tissues and has been known to inhibit NA(+)-K(+) ATPase in various tissues including skeletal and cardiac muscles and smooth muscles. Vanadate shows contractile...
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Modulation of L-type Ca2+ channel currents by various protein kinase activators and inhibitors in rat clonal pituitary GH3 cell line

Bae YM, Baek HJ, Cho HN, Earm YE, Ho WK

  • KMID: 2285234
  • Korean J Physiol Pharmacol.
  • 2001 Apr;5(2):139-146.
L-type Ca2+ channels play an important role in regulating cytosolic Ca2+ and thereby regulating hormone secretions in neuroendocrine cells. Since hormone secretions are also regulated by various kinds of protein kinases, we investigated...
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Enhanced Radiosensitivity of Tumor Cells Treated with Vanadate in Vitro

Lee MZ, Lee WY

  • KMID: 2196751
  • J Korean Soc Ther Radiol.
  • 1994 Jun;12(2):129-142.
Intracellular ions which have a major role in cellular function have been reported to affect repair of radiation damage. Recently it has been reported that ouabain sensitizes A549 tumor cells...
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The Effect of Vanadate on Glucase Transport of Everted Sacs and Vesicles Prepared from Small Intestinal Epithelial Cells

Hahm JS, Kim KJ

Vanadate has been reported to inhibit Na+, K+-ATPase of many cells. Since intestinal uptake of glucose is influenced by the enzyme, we studied the effects of varying concentrations of sodium...
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Role of Tyrosine Kinases in Norepinephrine-Induced Vascular Contraction in Renal Hypertensive Rats

Yeum CH, Jun JY, Yoon PJ, Shin MK, Cho HH, Jang JS, Hong SP, Yeum CH

BACKGROUND AND OBJECTIVES: Protein tyrosine kinases appear to be involved in the signal transduction mechanisms, which result in vascular smooth muscle contraction, as well those required in cell growth. The...
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The effects of vanadium oxide & sodium orthovanadate on murin osteoblast-like (MC3T3-E1) cells

Kwon KY, Chung KR

  • KMID: 2271186
  • Korean J Orthod.
  • 1994 Mar;24(1):17-35.
Vanadium is an essential trace element but has not been identified with a specific biogical role. To study the direct effects of vanadium on osteoblast, we incubated murin osteoblast-like (MC3T3-E1)...
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Effect of Orthovanadate on Collagen and Fibronectin Synthesis, and Alkaline Phosphatase Activity in MC3E3-E1 Osteoblast cells

Kim SY, Ihn JC, Choi JY, Ahn JC

  • KMID: 2105968
  • J Korean Orthop Assoc.
  • 2003 Apr;38(2):133-141.
PURPOSE: The purpose: of this study was to know the effect of inhibition of protein dephosphorylation on the synthesis of collagen and fibronectin (FN), alkaline phosphatase (ALP) activity, and the...
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Activation of epidermal growth factor receptor is responsible for pervanadate-induced phospholipase D activation

Kim YR, Cha HY, Lim K, Hwang BD, Hoe KL, Namgung U, Park SK

  • KMID: 1097260
  • Exp Mol Med.
  • 2003 Apr;35(2):118-124.
Pervanadate, a complex of vanadate and H2O2, has an insulin mimetic effect, and acts as an inhibitor of protein tyrosine phosphatase. Pervanadate-induced phospholipase D (PLD) activation is known to be...
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Insulin-dependent Stimulation of a Subtype of p38Map Kinases and Its Role in Insulin's Antiapoptotic Activity

Kang SH, Kang JH, Kang HK, Lee DH, Lee YK, Park DB

  • KMID: 2200523
  • J Korean Soc Endocrinol.
  • 2004 Aug;19(4):358-368.
BACKGROUND: The p38 mitogen-activated protein kinases (p38Map kinases) are a family of prolinedirected serine/threonine kinases. At least four isoforms of p38Map kinases have been identified; however, their physiological significances remain...
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Triptolide Inhibits the Proliferation of Immortalized HT22 Hippocampal Cells Via Persistent Activation of Extracellular Signal-Regulated Kinase-1/2 by Down-Regulating Mitogen-Activated Protein Kinase Phosphatase-1 Expression

Koo HS, Kang SD, Lee JH, Kim NH, Chung HT, Pae HO

OBJECTIVE: Triptolide (TP) has been reported to suppress the expression of mitogen-activated protein kinase (MAPK) phosphatase-1 (MKP-1), of which main function is to inactivate the extracellular signal-regulated kinase-1/2 (ERK-1/2), the...
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Effects of Vanadate on Cellular Ca2+ Movements in Guinea Pig Papillary Muscles

Suh CK, Park SR, Ahn DS, Paik KS

The effects of vanadate on cellular Ca2+ movements across the sarcolemma of cardiac muscle cells were investigated by measuring the intracellular and extracellular Ca2+ activities of guinea pig papillary muscle...
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Thyrotropin Suppresses INF-r Mediated Gene Expression by Inhibiting Signal Transducer and Activation of Transcription 1(STAT1) Activity in FRTL-5 Cells

Song MH, Kim YK, Ro HK, Park ES, Yoo SH, Kim H, Lee KW, Han HJ, Joo WC, Won JH, Lim K, Kwon OY

  • KMID: 1944212
  • J Korean Soc Endocrinol.
  • 1998 Dec;13(4):536-553.
BACKGROUND: The proinflammatory cytokine, IFN-y has been shown to exert pleiotropic effects in a variety of pathophysiologic conditions in autoimmune thyroid disease. The thyrocyte response to IFN-y is mediated two...
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Regulation of chicken protein tyrosine phosphatase 1 and human protein tyrosine phosphatase 1B activity by casein kinase II- and p56lck-mediated phosphorylation

Kang KR, Kim CW

  • KMID: 927134
  • Exp Mol Med.
  • 2000 Mar;32(1):47-51.
Protein tyrosine phosphorylation and dephosphorylation are important in the regulation of cell proliferation and signaling cascade. In order to examine whether phosphatase activity of CPTP1 and HPTP1B, typical nontransmembrane protein...
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Effects of vanadate on vascular contractility and membrane potential in the rabbit aorta

Chung SM, Ahn DS, Seok HS, Jeong Y, Kang BS

Isolated rabbit aortic ring with intact endothelial cell preparations precontracted with NE (10(-7) M) were relaxed by vanadate in a dose dependent manner (from 0.2 to 2 mM). Application of...
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The p38 mitogen-activated protein kinase is involved in stress-induced phospholipase D activation in vascular smooth muscle cells

Min DS, Shin EY, Kim EG

  • KMID: 1093596
  • Exp Mol Med.
  • 2002 Mar;34(1):38-46.
Oxidative stress has been implicated in mediation of vascular disorders. Earlier study showed that the exposure of vascular smooth muscle cells (VSMC) to pervanadate (hydrogen peroxide plus orthovanadate) resulted in...
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