- Tyrphostin ErbB2 Inhibitors AG825 and AG879 Have Non-specific Suppressive Effects on gp130/ STAT3 Signaling
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Lee HK, Seo IA, Lee SH, Seo SY, Kim KS, Park HT
- KMID: 1486111
- Korean J Physiol Pharmacol.
- 2008 Oct;12(5):281-286.
- doi: 10.4196/kjpp.2008.12.5.281
Although the interaction between gp130 and the ErbB family has frequently been shown in cancer cells, the mechanism of this interaction remains unclear and controversial. In the present study, we... -
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- Effect of Jak2 Inhibitor AG490 on Osteoclast Differentiation
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Lee CH, Choi MK, Kim JJ, Lee MS, Cho HJ, Kim HS, Kim JW, Oh J
- KMID: 2092950
- Korean J Anat.
- 2008 Dec;41(4):265-270.
Osteoclasts are cells of hemopoietic origin that play an critical role in bone resorption and responsible for bone diseases, including osteoporosis, periodontal disease, and rheumatoid arthritis. In this study, we... -
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- Inhibitory Effect of Tyrphostin AG126 on Brain Synaptosomal Dysfunction Induced by Cholesterol Oxidation Products
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Hong KM, Han JH, Kim DE, Song JH, Lee CS
- KMID: 2185067
- J Korean Neurol Assoc.
- 2008 Aug;26(3):231-238.
BACKGROUND: Formation of cholesterol oxidation products is a suggested mechanism of neurodegenerative disorders. Neuronal cell death is mediated by an increased release of excitotoxic glutamate from the presynaptic nerve endings.... -
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- Janus Kinase 2 Inhibitor AG490 Inhibits the STAT3 Signaling Pathway by Suppressing Protein Translation of gp130
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Seo IA, Lee HK, Shin YK, Lee SH, Seo SY, Park JW, Park HT
- KMID: 2071662
- Korean J Physiol Pharmacol.
- 2009 Apr;13(2):131-138.
- doi: 10.4196/kjpp.2009.13.2.131
The binding of interleukin-6 (IL-6) cytokine family ligands to the gp130 receptor complex activates the Janus kinase (JAK)/ signal transducer and activator of transcription 3 (STAT3) signal transduction pathway,... -
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- Role of Angiogenic Factors in Airway Remodeling in an Allergic Rhinitis Murine Model
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Moon IJ, Kim DY, Rhee CS, Lee CH, Min YG
- KMID: 2130377
- Allergy Asthma Immunol Res.
- 2012 Jan;4(1):37-45.
- doi: 10.4168/aair.2012.4.1.37
PURPOSE: There is growing evidence that nasal airway remodeling occurs in allergic rhinitis (AR). Although angiogenesis is an important component of airway remodeling in asthma, its involvement in AR has... -
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- Beta agonist regulation of sodium transport in fetal lung epithelium: roles of cell volume, cytosolic chloride and protein tyrosine kinase
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Marunaka Y, Niisato N, Ito Y
- KMID: 1026947
- J Korean Med Sci.
- 2000 Aug;15(Suppl):S42-S43.
- doi: 10.3346/jkms.2000.15.S.S42
1) A beta agonist stimulated Na+ transport and decreased the intracellular Cl concentration ([Cl]c) associated with cell shrinkage via an increase in cytosolic cAMP level by activating adenylate cyclase in... -
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- Lysophosphatidic acid receptor 2 and Gi/Src pathway mediate cell motility through cyclooxygenase 2 expression in CAOV-3 ovarian cancer cells
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Jeong KJ, Park SY, Seo JH, Lee KB, Choi WS, Han JW, Kang JK, Park CG, Kim YK, Lee HY
- KMID: 1072941
- Exp Mol Med.
- 2008 Dec;40(6):607-616.
- doi: 10.3858/emm.2008.40.6.607
Lysophosphatidic acid (LPA) is a bioactive phospholipids and involves in various cellular events, including tumor cell migration. In the present study, we investigated LPA receptor and its transactivation to EGFR... -
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