- Immunohistochemical study of inositol phospholipid-specific phospholipase C in the rat liver and kidney
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Kim DS, Hwang SJ, Kim DH, Suh YS
- KMID: 1686672
- Korean J Anat.
- 1993 Mar;26(1):103-115.
No abstract available. -
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- Effects of psychotropic drugs on phospholipase C and protein kinase C in vitro
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Choi Y, Lee KY, Lee HY
- KMID: 2197826
- J Korean Neuropsychiatr Assoc.
- 1992 Sep;31(5):837-845.
No abstract available. -
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- Homogeneity of Phospholipase C of Bovine Uterus and Seminal Vesicle Compared with Brain Isozymes
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Kim JH, Lee KY, Rhee SG
- KMID: 2376234
- Yeungnam Univ J Med.
- 1988 Dec;5(2):37-45.
- doi: 10.12701/yujm.1988.5.2.37
Phosphoinositide-specific Phospholipase C (PI-PLC) is a second messenger of signal transducer on cell membrane. In the previous study, PLC of bovine brain has been purified three isozymes. In this paper,... -
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- Effect of Extremely Low Frequency Electromagnetic Fields (EMF) on Phospholipase Activity in the Cultured Cells
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Song HS, Kim HR, Ko MS, Jeong JM, Kim YH, Kim MC, Hwang YH, Sohn UD, Gimm YM, Myung SH, Sim SS
- KMID: 2071716
- Korean J Physiol Pharmacol.
- 2010 Dec;14(6):427-433.
- doi: 10.4196/kjpp.2010.14.6.427
This study was conducted to investigate the effects of extremely low frequency electromagnetic fields (EMF) on signal pathway in plasma membrane of cultured cells (RAW 264.7 cells and RBL 2H3... -
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- Expression of Phospholipase C-B3 using Recombinant Baculovirus Expression System
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Park DJ
- KMID: 2331069
- J Korean Soc Endocrinol.
- 1997 Jun;12(2):283-294.
BACKGROUND: Although phospholipase C (PLC)-B3 is thought to be a very important enzyme in intracellular signal transduction, the sophisticated and complicated purification steps make it difficult to obtain sufficient amount... -
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- Distributional patterns of phospholipase C isozymes in heart and brain of spontaneously hypertensive and normotensive rats
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Choi JW, Cho YJ, Cha SH, Lee KH, Lee SB
- KMID: 2071510
- Korean J Physiol Pharmacol.
- 1997 Aug;1(4):385-392.
The phospholipase C (PLC)-mediated intracellular signal transduction pathway is considered to be involved in the regulation of blood pressure. However, little information is available concerning the distributional and functional significance of PLC in... -
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- Identification of phospholipase C β downstream effect on transient receptor potential canonical 1/4, transient receptor potential canonical 1/5 channels
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Ko J, Myeong J, Kwak M, Jeon JH, So I
- KMID: 2455812
- Korean J Physiol Pharmacol.
- 2019 Sep;23(5):357-366.
- doi: 10.4196/kjpp.2019.23.5.357
Gα(q)-coupled receptor stimulation was implied in the activation process of transient receptor potential canonical (TRPC)1/4 and TRPC1/5 heterotetrameric channels. The inactivation occurs due to phosphatidylinositol 4,5-biphosphate (PI(4,5)P₂) depletion. When PI(4,5)P₂... -
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- Distribution of Phospholipase C Isozymes in Rat Retina: Immunohistochemical Study
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Yoo JM, Choi WS, Kim MO, Yoon HW, Park JM, Song JK
- KMID: 2205015
- J Korean Ophthalmol Soc.
- 1992 Dec;33(12):1194-1199.
In order to explore the existence and distribution of phospholipase (PLC) isozymes in the rat retina, immunohistochemical staining was applied using monoclonal antibodies against PLC isozymes (PLC beta; K92, PLC... -
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- The role of G protein in the activation of phospholipase C from bovine brain
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Kim JH, Lee DJ, Byun YJ
- KMID: 2377584
- Yeungnam Univ J Med.
- 1992 Dec;9(2):288-301.
- doi: 10.12701/yujm.1992.9.2.288
The objective of the present study was to identify the characteristics of phospholipase C (PLC) isozymes purified from bovine brain and to investigate their interrelationship with G protein. The purified PLC... -
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- Cromakalim blocks membrane phosphoinositide activated signals in the guinea pig lung mast cells stimulated with antigen-antibody reactions
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Ro JY, Kim JY, Kim KH
- KMID: 1562328
- Korean J Physiol Pharmacol.
- 1998 Apr;2(2):251-260.
Cromakalim (BRL 34915), known as an airway smooth muscle relaxant, inhibited the releases of mediators in the antigen-induced mast cell activation. It has been suggested that cromakalim, in part, inhibited mediator releases by... -
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- Signal Transduction Mechanisms Mediating Surfactant Phospholipid Secretion in Isolated Type II Cell
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Park SS
- KMID: 2317983
- Tuberc Respir Dis.
- 1996 Apr;43(2):123-127.
Secretion of surfactant phospholipid can be stimulated by a variety of agonists acting via at least three different signal transduction mechanisms. These include the adenylate cyclase system with activation of... -
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- Expression of Phospholipase C-gamma1 and gamma2 in Non-Hodgkin's and Hodgkin's Lymphoma
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Eom DW, Kim SS, Woo YJ, Suh JH, Huh J, Paik AR, Kim JH, Ryu SH, Suh PG
- KMID: 1725651
- Korean J Pathol.
- 2000 Feb;34(2):113-118.
Phospholipase C (PLC) plays a role in ligand-mediated signal transduction for cellular activity such as proliferation and differentiation. A recent observation that PLC- gamma1 is highly expressed in some kinds of... -
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- Enhanced coupling of M-1 muscarinic receptors to activation of phospholipase C upon mutation of a transposed amino acid triplet repeat
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Lee SY, Sung KW, Kim ON, Lee SB
- KMID: 2285154
- Korean J Physiol Pharmacol.
- 1997 Feb;1(1):19-25.
The C-terminus ends of the second putative transmembrane domains of both M-1 and M-2 Muscarinic receptors contain a triplet of amino acid residues consisting of leucine (L), tyrosine (Y) and threonine (T). This... -
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- Differential Effect of Genistein and Calphostin C on Phospholipase C Activation and Cell Proliferation in T98G Human Glioblastoma and Hs 683 Human Glioma Cells
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Choi CM, Kim Y, Kim BY, Yang JH, Lee IW, Jung CK, Kang JK
- KMID: 1955536
- J Korean Neurosurg Soc.
- 1998 Aug;27(8):1029-1038.
Amajor role in sustaining tumors like gliomas has been attributed to growth factors. Many questions remain unanswered about how such external signals are transduced into a transformed phenotype. Growth factors... -
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- The Pattern of Expression of Phospholipase C-gamma in Benign and Malignant Tumors of the Breast
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Kim HJ, Chung KW, Kim SW, Moon BI, Ahn SJ, Noh DY, Yoo KY, Choe KJ
- KMID: 2209462
- J Korean Surg Soc.
- 2002 Jun;62(6):463-467.
PURPOSE: The activation of phospholipase C (PLC) is one of the early events in various growth processes, including malignant transformation. Among PLC-isozymes, PLC-gamma is activated through direct interaction with growth... -
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- Expression and Purification of Phospholipase C-beta4, and Chimeric Phospholipase C and Characterization of Them
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Park DJ
- KMID: 1973790
- Endocrinol Metab.
- 2012 Dec;27(4):282-288.
- doi: 10.3803/EnM.2012.27.4.282
BACKGROUND: Phospholipase C-beta4 (PLC-beta4) is known to be one of the most important signal transducing molecules; however, its biophysical and chemical characteristics are not well known due to the difficulty... -
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- Mechanism of Angiotensin 2-Stimulated Aldosterone Secretion in Adrenal Glomerulosa Cells of Diabetic Rats ; Normal Phospholipase Activity and Intracellular Calcium Mobilization
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Sung YA, Kyung NH
- KMID: 2331064
- J Korean Soc Endocrinol.
- 1997 Jun;12(2):230-244.
BACKGROUND: Diabetic patients develop hypoaldosteronism which frequently caused hyperkalemia and metabolic acidosis and diabetic hypoaldosteronism is associated with selective unresponsiveness of aldosterone to angiotensin A-II, but mechanism of defect in... -
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- Effect of Sphingosine-1-Phosphate on Intracellular Free Ca2+ in Cat Esophageal Smooth Muscle Cells
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Lee DK, Min YS, Yoo SS, Shim HS, Park SY, Sohn UD
- KMID: 2427507
- Biomol Ther.
- 2018 Nov;26(6):546-552.
- doi: 10.4062/biomolther.2018.053
A comprehensive collection of proteins senses local changes in intracellular Ca²⺠concentrations ([Ca²âº](i) and transduces these signals into responses to agonists. In the present study, we examined the effect of... -
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- Effect of Phospholipase C-gamma1 Overexpression on the Protein Level of Waf1, PCNA, and Cyclin B1 Following Ultraviolet C Irradiation
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Shin SY, Lee YH, Baek SH, Kim SY, Kim JR, Kim JH
- KMID: 1804434
- Cancer Res Treat.
- 2001 Oct;33(5):427-432.
PURPOSE: It has been demonstrated that PLC-gamma1 is overexpressed in many tumor cells, and that overexpression of Phospholipase C (PLC)-gamma1 is associated with tumor progression. In order to understand the... -
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- The expression of phospholipase C and Siah gene product during murine fetal development by immunohistochemistry
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Park EM, Kim SS, Choi KG, Park KD, Suh PG, Shin HS
- KMID: 2066076
- J Korean Neurol Assoc.
- 1997 Jun;15(3):455-462.
Recently identified second messenger molecules of signal transmission were derived from inositol phospholipid and several phospholipase C(PLC) isoenzyme were reconized. But the role of PLC in embryonal organ development, differentiation... -
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