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Prologation of c-Jun N-Terminal Kinase is Associated with Cell Death Induced by Tumor Necrosis Factor Alpha in Human Chondrocytes

Yoon HS, Kim HA

The aim of this study was to elucidate the role of JNK signaling pathway involved in tumor necrosis factor-alpha (TNF-alpha)-induced death of chondrocytes. Primary chondrocyte cultures were obtained from human...
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Effects of TNF-alpha on Angiogenesis in CT-26 Mouse Colon Carcinoma Homograft Model

Chun JW, Jung JT, Oh HK, Bae JY, Shin IH, Cho CH

  • KMID: 935194
  • Korean J Gastroenterol.
  • 2005 Dec;46(6):440-446.
BACKGROUND/AIMS: Tumor necrosis factor-alpha (TNF-alpha) exerts its anti-tumor effect through direct cytotoxicity on tumor cells and damage to the tumor vasculature. However, its role in tumor angiogenesis is controversial. We...
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Msx2 mediates the inhibitory action of TNF-alpha on osteoblast differentiation

Lee HL, Yi T, Woo KM, Ryoo HM, Kim GS, Baek JH

TNF-alpha, a proinflammatory cytokine, inhibits osteoblast differentiation under diverse inflammatory conditions; however, the underlying mechanisms in terms of the TNF-alpha signaling pathway remain unclear. In this study, we examined the...
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Induction of steroid sulfatase expression by tumor necrosis factor-alpha through phosphatidylinositol 3-kinase/Akt signaling pathway in PC-3 human prostate cancer cells

Suh BY, Jung JJ, Park N, Seong CH, Im HJ, Kwon Y, Kim D, Chun YJ

Steroid sulfatase (STS) is responsible for the hydrolysis of aryl and alkyl steroid sulfates and has a pivotal role in regulating the formation of biologically active estrogens. STS may be...
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TNF-alpha upregulates PTEN via NF-kappaB signaling pathways in human leukemic cells

Lee YR, Yu HN, Noh EM, Youn HJ, Song EK, Han MK, Park CS, Kim BS, Park YS, Park BK, Lee SH, Kim JS

  • KMID: 1103688
  • Exp Mol Med.
  • 2007 Feb;39(1):121-127.
TNF-alpha plays a variety of biological functions such as apoptosis, inflammation and immunity. PTEN also has various cellular function including cell growth, proliferation, migration and differentiation. Thus, possible relationships between...
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Epigallocatechin-3-gallate Suppresses Galactose-alpha1,4-galactose-beta1,4-glucose Ceramide Expression in TNF-alpha Stimulated Human Intestinal Epithelial Cells Through Inhibition of MAPKs and NF-kappa B

Moon DO, Choi SR, Lee CM, Kim GY, Lee HJ, Park YM

Intestinal epithelial cells (IECs) have been known to produce galactose-alpha1,4-galactose-beta1,4-glucose ceramide (Gb3) that play an important role in the mucosal immune response. The regulation of Gb3 is important to prevent...
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Inflammatory Gene Expression Patterns Revealed by DNA Microarray Analysis in TNF-alpha-treated SGBS Human Adipocytes

Do MS, Jeong HS, Choi BH, Hunter L, Langley S, Pazmany L, Trayhurn P

We report here the use of human inflammation arrays to study the inflammatory gene expression profile of TNF-alpha- treated human SGBS adipocytes. Human preadipocytes (SGBS) were induced to differentiate in...
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Transient exposure to hydrogen peroxide inhibits the ubiquitination of phosphorylated IkappaBalpha in TNFalpha-stimulated HEK293 cells

Lee Y, Choi J, Ha KH, Jue DM

  • KMID: 1387362
  • Exp Mol Med.
  • 2012 Aug;44(8):513-520.
During ischemia-reperfusion injury, brief pre-exposure to oxidative stress renders organs resistant to subsequent severe damage. NF-kappaB is a transcription factor that is involved in reperfusion-induced inflammatory and immune responses. The...
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