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Biological Activities and Stability of a Standardized Pentacyclic Triterpene Enriched Centella asiatica Extract

Puttarak P, Brantner A, Panichayupakaranant P

Pentacyclic triterpenes, mainly, asiatic acid, madecassic acid, asiaticoside, and madecassoside are the active constituents of Centella asiatica. A pentacyclic triterpene enriched C. asiatica extract (PRE) was prepared and standardized to...
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Phenolic Compounds and Triterpenes from the Barks of Diospyros burmanica

Choi J, Cho JY, Kim YD, Htwe KM, Lee WS, Lee JC, Kim J, Yoon KD

Diospyros burmanica Kurz. is an evergreen deciduous tree distributed in Mandalay of Myanmar, which belongs to the family of Ebenaceae. In Myanmar, it has been used to treat diarrhea, diabetes,...
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First Report of Heterodermia squamulosa (Lichenized Ascomycota, Physciaceae) in South Korea

Wang XY, Hur H, Lee YM, Koh YJ, Hur JS

Heterodermia squamulosa (Degel.) W.L. Culb. was found in the mountain of Gariwang, Gangwon province, in 2008. It is characterized by numerous squamules along the margin, decorticate and white lower surface,...
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Anti-inflammatory Triterpenes and Glyceryl Glycosides from Kandelia candel (L.) Druce

Dat LD, Thao NP, Tai BH, Luyen BT, Yang SY, Kim S, Koo JE, Koh YS, Cuong NT, Nam NH, Thanh NV, Kiem PV, Minh CV, Kim YH

Phytochemical investigation of Kandelia candel resulted in the isolation of six triterpenes (1 - 5) and two glyceryl glycosides (6 and 7) and their structures were determined by comparing the...
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Soluble Epoxide Hydrolase Inhibitory Activity from Euphorbia supina Rafin

Luyen BT, Thao NP, Tai BH, Dat LD, Kim JE, Yang SY, Kwon SU, Lee YM, Kim YH

In our search for natural soluble epoxide hydrolase (sEH) inhibitors from plants, an extract of the dried whole plants of Euphorbia supina Rafin was found to significantly inhibit sEH activity...
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Antishigellosis and Cytotoxic Potency of Crude Extracts and Isolated Constituents from Duranta repens

Nikkon F, Habib MR, Karim MR, Hossain MS, Mosaddik M, Haque ME

The crude ethanol extracts (stem and fruits), their fractions and two triterpenes, beta-Amyrin and 12-Oleanene 3beta, 21beta-diol, isolated as a mixture from the chloroform soluble fraction of an ethanolic extract...
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Chemical Constituents from Leaves of Pileostegia viburnoides Hook.f.et Thoms

Li XJ, Liu ZZ, Kim KW, Wang X, Li Z, Kim YC, Yook CS, Liu XQ

Phytochemical investigation on the leaves of Pileostegia viburnoides Hook.f.et Thoms led to the isolation of twenty-five compounds, and their structures were identified as n-dotriacontane (1), taraxeryl acetate (2), friedelin (3),...
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Hypolipidemic and Antioxidant Effects to Ginseng Extract (PD:PT = 1) in Apo E Null Mice

Jang S, Kim SS, Lee M

  • KMID: 2263025
  • Korean J Nutr.
  • 2008 Oct;41(7):594-601.
Panax ginseng C.A. Meyer (Panax ginseng) has been used for several thousand years to prolong longevity in Asian countries. Ginsenosides are the most active components isolated from ginseng and belong...
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Mineral, Nutritional, and Phytochemical Profile, Total Phenolic Content, and Radical Scavenging Activity of Philippine Bamboo "Bolo" Gigantochloa levis (Blanco) Merr. Leaves

Tongco JV, Rodriguez , Abasolo WP, Mun SP, Razal RA

The study is a pioneering effort to determine the mineral, nutritional, and phytochemical composition and phenolic content and to determine the free radical scavenging activity of Gigantochloa levis (Blanco) Merr,...
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Antimicrobial Effects of Ursolic Acid against Mutans Streptococci Isolated from Koreans

Kim MJ, Kim CS, Park JY, Lim YK, Park SN, Ahn SJ, Jin DC, Kim TH, Kook JK

  • KMID: 2135278
  • Int J Oral Biol.
  • 2011 Mar;36(1):7-11.
Ursolic acid is a triterpenoid compound present in many plants. This study examined the antimicrobial activity of ursolic acid against mutans streptococci (MS) isolated from the Korean population. The antimicrobial...
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Inhibition of Streptococcus mutans biofilm formation on composite resins containing ursolic acid

Kim S, Song M, Roh BD, Park SH, Park JW

OBJECTIVES: To evaluate the inhibitory effect of ursolic acid (UA)-containing composites on Streptococcus mutans (S. mutans) biofilm. MATERIALS AND METHODS: Composite resins with five different concentrations (0.04, 0.1, 0.2, 0.5, and...
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Betulinic acid prevents alcohol-induced liver damage by improving the antioxidant system in mice

Yi J, Xia W, Wu J, Yuan L, Wu J, Tu D, Fang J, Tan Z

Betulinic acid (BA), a pentacyclic lupane-type triterpene, has a wide range of bioactivities. The main objective of this work was to evaluate the hepatoprotective activity of BA and the potential...
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Immunomodulatory effects of betulinic acid from the bark of white birch on mice

Yi JE, Obminska-Mrukowicz B, Yuan LY, Yuan H

The objective of this study was to explore the immunomodulatory effects of betulinic acid (BA) extracted from the bark of white birch on mice. Female mice were orally administered BA...
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Chemistry and Cancer Preventing Activities of Ginseng Saponins and Some Related Triterpenoid Compounds

Shibata S

More than 25 dammarane-type tetracyclic triterpenoid saponins have been isolated from ginseng, the root and rhizome of Panax ginseng C.A. Meyer (Araliaceae). The genuine sapogenins of those saponins, 20(S)-protopanaxa-diol and...
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Curcuminoid-phospholipid complex induces apoptosis in mammary epithelial cells by STAT-3 signaling

Cucuzza LS, Motta M, Miretti S, Accornero , Baratta M

Curcumin (from the rhizome of Curcuma longa) is well documented for its medicinal properties in Indian and Chinese systems of medicine where it is widely used for the treatment of...
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Celastrol inhibits production of nitric oxideandproinflammatory cytokines through MAPK signal transduction and NF-kappaB in LPS-stimulated BV-2 microglial cells

Jung HW, Chung YS, Kim YS, Park YK

  • KMID: 1091066
  • Exp Mol Med.
  • 2007 Dec;39(6):715-721.
Excessive production of nitric oxide (NO) and proinflammatory cytokines from activated microglia play an important role in human neurodegenerative disorders. Here, we investigated whether celastrol, which has been used as...
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