- Induction of hepatic ATP-citrate lyase by insulin in diabetic rat--effects of insulin on the contents of enzyme and its mRNA in cytosol, and the transcriptional activity in nuclei
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Park SW, Kim KS, Whang SK, Kim JS, Kim YS
- KMID: 1381214
- Yonsei Med J.
- 1994 Mar;35(1):25-33.
- doi: 10.3349/ymj.1994.35.1.25
The effects of insulin on ATP-citrate lyase, its mRNA in cytosol, and the transcriptional activity in nuclei of diabetic rat liver were studied. Experimental diabetes was induced by an intraperitoneal... -
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- ATM modulates transcription in response to histone deacetylase inhibition as part of its DNA damage response
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Jang ER, Choi JD, Park MA, Jeong G, Cho H, Lee JS
- KMID: 946652
- Exp Mol Med.
- 2010 Mar;42(3):195-204.
- doi: 10.3858/emm.2010.42.3.020
Chromatin structure has a crucial role in a diversity of physiological processes, including development, differentiation and stress responses, via regulation of transcription, DNA replication and DNA damage repair. Histone deacetylase... -
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- Regulation of leptin gene expression by insulin and growth hormone in mouse adipocytes
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Lee KN, Jeong IC, Lee SJ, Oh SH, Cho MY
- KMID: 1457535
- Exp Mol Med.
- 2001 Dec;33(4):234-239.
The role of leptin in the control of obesity, insulin resistance and type II diabetes has been reported, however, the regulatory mechanism of leptin in animals affected by hormones is... -
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- Differential promoter methylation may be a key molecular mechanism in regulating BubR1 expression in cancer cells
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Park HY, Jeon YK, Shin HJ, Kim IJ, Kang HC, Jeong SJ, Chung DH, Lee CW
- KMID: 1094660
- Exp Mol Med.
- 2007 Apr;39(2):195-204.
The BubR1 mitotic-checkpoint protein monitors proper attachment of microtubules to kinetochores, and links regulation of chromosome-spindle attachment to mitotic-checkpoint signaling. Thus, disruption of BubR1 activity results in a loss of... -
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- Rebamipide-induced downregulation of phospholipase D inhibits inflammation and proliferation in gastric cancer cells
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Kang DW, Min G, Park DY, Hong KW, Min DS
- KMID: 1104382
- Exp Mol Med.
- 2010 Aug;42(8):555-564.
- doi: 10.3858/emm.2010.42.8.056
Rebamipide a gastroprotective drug, is clinically used for the treatment of gastric ulcers and gastritis, but its actions on gastric cancer are not clearly understood. Phospholipase D (PLD) is overexpressed... -
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- Apoptotic Effects of Genistein, Biochanin-A and Apigenin on LNCaP and PC-3 Cells by p21 through Transcriptional Inhibition of Polo-like Kinase-1
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Seo YJ, Kim BS, Chun SY, Park YK, Kang KS, Kwon TG
- KMID: 1123450
- J Korean Med Sci.
- 2011 Nov;26(11):1489-1494.
- doi: 10.3346/jkms.2011.26.11.1489
Natural isoflavones and flavones are important dietary factors for prostate cancer prevention. We investigated the molecular mechanism of these compounds (genistein, biochanin-A and apigenin) in PC-3 (hormone-independent/p53 mutant type) and... -
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- Celastrol inhibits production of nitric oxideandproinflammatory cytokines through MAPK signal transduction and NF-kappaB in LPS-stimulated BV-2 microglial cells
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Jung HW, Chung YS, Kim YS, Park YK
- KMID: 1091066
- Exp Mol Med.
- 2007 Dec;39(6):715-721.
Excessive production of nitric oxide (NO) and proinflammatory cytokines from activated microglia play an important role in human neurodegenerative disorders. Here, we investigated whether celastrol, which has been used as... -
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- The role of tonicity responsive enhancer sites in the transcriptional regulation of human hsp70-2 in response to hypertonic stress
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Heo JI, Lee MS, Kim JH, Lee JS, Kim J, Park JB, Lee JY, Han JA, Kim JI
- KMID: 1094155
- Exp Mol Med.
- 2006 Jun;38(3):295-301.
The inducible 70 kDa heat shock proteins (Hsp70) in mice are encoded by two almost identical genes, hsp70.1 and hsp70.3. Studies have found that only hsp70.1 is induced by hypertonic... -
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- Antinociceptive Effects of Amiloride and Benzamil in Neuropathic Pain Model Rats
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Jeong S, Lee SH, Kim YO, Yoon MH
- KMID: 1793032
- J Korean Med Sci.
- 2013 Aug;28(8):1238-1243.
- doi: 10.3346/jkms.2013.28.8.1238
Amiloride and benzamil showed antinocicepitve effects in several pain models through the inhibition of acid sensing ion channels (ASICs). However, their role in neuropathic pain has not been investigated. In... -
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- Identification of glucocorticoid response element of the rat TRH gene
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Lee GC, Yang IM, Kim BJ, Woo JT, Kim SW, Kim JW, Kim YS, Choi YK
- KMID: 1051555
- Korean J Intern Med.
- 1996 Jun;11(2):138-144.
OBJECTIVES: It was suggested that glucocorticoid exerts cell-specific effects on thyrotropin-releasing hormone (TRH) gene expression at the transcriptional level. Although there is no typical palindromic glucocorticoid response element (GRE) on... -
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- Grifola frondosa water extract alleviates intestinal inflammation by suppressing TNF-alpha production and its signaling
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Lee JS, Park SY, Thapa D, Choi MK, Chung IM, Park YJ, Yong CS, Choi HG, Kim JA
- KMID: 983987
- Exp Mol Med.
- 2010 Feb;42(2):143-154.
- doi: 10.3858/emm.2010.42.2.016
TNF-alpha is a major cytokine involved in inflammatory bowel disease (IBD). In this study, water extract of Grifola frondosa (GFW) was evaluated for its protective effects against colon inflammation through... -
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- Impact of Lysophosphatidylcholine on the Plasminogen Activator System in Cultured Vascular Smooth Muscle Cells
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Yoon BK, Kang YH, Oh WJ, Park K, Lee DY, Choi D, Kim DK, Lee Y, Rhyu MR
- KMID: 2157928
- J Korean Med Sci.
- 2012 Jul;27(7):803-810.
- doi: 10.3346/jkms.2012.27.7.803
The balance between tissue-type plasminogen activator (t-PA) and plasminogen activator inhibitor type 1 (PAI-1) regulates fibrinolysis. PAI-1 expression increases in atherosclerotic arteries and vascular smooth muscle cells (VSMCs) are one... -
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- Ox-LDL suppresses PMA-induced MMP-9 expression and activity through CD36-mediated activation of PPAR-gamma
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Lee KJ, Kim HA, Kim PH, Lee HS, Ma KR, Park JH, Kim DJ, Hahn JH
- KMID: 1103320
- Exp Mol Med.
- 2004 Dec;36(6):534-544.
During chronic inflammatory response, mono- cytes/macrophages produce 92-kDa matrix metalloproteinase-9 (MMP-9), which may contribute to their extravasation, migration and tissue remodeling. Activation of peroxisome proliferator- activated factor receptor-gamma (PPAR-gamma) has... -
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