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Letter to the editor: Questioning the evidence behind the Saturation Model for testosterone replacement therapy in prostate cancer

Morgentaler A, Traish AM

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Impact of Testosterone Deficiency and Testosterone Therapy on Lower Urinary Tract Symptoms in Men with Metabolic Syndrome

Traish AM, Johansen V

Lower urinary tract function is modulated by neural, vascular and urethral and bladder structural elements. The pathophysiological mechanisms of lower urinary tract symptoms (LUTS) encompass prostate enlargement, alterations in urethra...
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Androgens Modulate Endothelial Function and Endothelial Progenitor Cells in Erectile Physiology

Traish AM, Galoosian

  • KMID: 2315951
  • Korean J Urol.
  • 2013 Nov;54(11):721-731.
The incidence of erectile dysfunction (ED) increases with age and cardiovascular disease risk factors, such as hypertension, hyperlipidemia, insulin resistance, obesity, and diabetes. These risk factors are thought to contribute...
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Health Risks Associated with Long-Term Finasteride and Dutasteride Use: It’s Time to Sound the Alarm

Traish AM

5α-dihydrotestosterone (5α-DHT) is the most potent natural androgen. 5α-DHT elicits a multitude of physiological actions, in a host of tissues, including prostate, seminal vesicles, hair follicles, skin, kidney, and lacrimal...
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Diabetes Attenuates Female Genital Sexual Arousal Response via Disruption of Estrogen Action

Traish AM, Cushman T, Hoyt R, Kim NN

  • KMID: 2311872
  • Korean J Urol.
  • 2009 Mar;50(3):211-223.
PURPOSE: Diabetes profoundly and negatively impacts all domains of female sexual function, however, the underlying pathophysiological mechanisms remain unknown. To date, limited studies have been published on the effects of...
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The Dark Side of 5alpha-Reductase Inhibitors' Therapy: Sexual Dysfunction, High Gleason Grade Prostate Cancer and Depression

Traish AM, Mulgaonkar A, Giordano N

With aging, abnormal benign growth of the prostate results in benign prostate hyperplasia (BPH) with concomitant lower urinary tract symptoms (LUTS). Because the prostate is an androgen target tissue, and...
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