- A case of occupational asthma with systemic illness due to toluene diisocyanate and diphenylmethane diisocyanate
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Park HS, Cho YS, Lim YS, Rhu NS, Cho DI, Kim JW
- KMID: 1734153
- Allergy.
- 1991 Mar;11(1):70-75.
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- Occupational Asthma due to Styrene and Toluene Diisocyanate
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- KMID: 2299630
- Korean J Asthma Allergy Clin Immunol.
- 2007 Mar;27(1):70-73.
Styrene, a common solvent and volatile organic compound (VOC), is widely used in the factories of plastics, resins, insulators, coatings, and paints. While toluene diisocyanate (TDI) is a well-known causative... -
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- Significant changes of bronchial responsiveness to methacholine after early asthmatic reaction to toluene diisocyanate (TDI) in a TDI-sensitive asthmatic worker
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Park HS, Cho YS, Park JN, Baik JH, Rhu NS, Cho DI, Kim JW
- KMID: 1421499
- J Korean Med Sci.
- 1990 Dec;5(4):185-188.
- doi: 10.3346/jkms.1990.5.4.185
Current asthma is often diagnostically excluded by the presence of normal bronchial responsiveness. We report on a TDI-induced occupational asthma patient with normal bronchial responsiveness. He had suffered from shortness... -
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- A Case of Chromium- and Toluene Diisocyanate-Induced Asthma
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- KMID: 2299671
- Korean J Asthma Allergy Clin Immunol.
- 2005 Sep;25(3):223-227.
There have been case reports of occupational asthma (OA) due to chromium in cement workers. Isocyanates are used in the manufacture of numerous products, such as polyurethane paints, and are... -
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- Prevalence and Clinical Significance of New Sensitization to Inhalant Allergens in Toluene Diisocyanate-induced Asthmatic Patients
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- KMID: 2234387
- Korean J Asthma Allergy Clin Immunol.
- 2006 Sep;26(3):213-218.
BACKGROUND: It has been reported that half of toluene diisocyanate (TDI)-induced asthma patients had persistent asthmatic symptoms even after complete avoidance. We hypothesized that new sensitization to common inhalant allergens... -
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- Biological Monitorings of Workers Exposed to Toluene diisocyanate
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Ahn YS, Roh JH, Kim CN, Park YJ, Jung SH
- KMID: 1924149
- Korean J Occup Environ Med.
- 1995 Oct;7(2):354-361.
Toluene diisocyanate (TDI) is widely used in the production of flexible polyurethane foams, as well as in the formulation of polyurethane paints and coatings. The commercial material is generally a... -
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- A Murine Model of Toluene Diisocyanate-induced Contact Hypersensitivity
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Chai OH, Park SG, Sohn JS, Hwang SS, Li GZ, Han EH, Kim HT, Lee MS, Lee HK, Lee YC, Song CH
- KMID: 1571518
- Immune Netw.
- 2002 Sep;2(3):158-165.
- doi: 10.4110/in.2002.2.3.158
BACKGROUND: Toluene diisocyanate (TDI) can cause contact allergy and occupational asthma, but the mechanism underlying sensitization to this chemical compound remains controversal. Also the correlation of mast cell with contact... -
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- Diverse profiles of specific IgE response to toluene diisocyanate (TDI)-human serum albumin conjugate in TDI-induced asthma patients
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Park HS, Kim HY, Lee SK, Kim SS, Nahm DH
- KMID: 1066495
- J Korean Med Sci.
- 2001 Feb;16(1):57-61.
- doi: 10.3346/jkms.2001.16.1.57
The prevalence studies on specific IgE to toluene diisocyanate (TDI)-human serum albumin (HSA) conjugate in TDI-induced asthma have shown variable results. In this study, we attempted to compare specific IgE... -
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- Clinical significance of specific IgG and IgE antibodies to toluene diisocyanate ( TDi ) - human - serum albumin ( HSA ) conjugate in TDI - induceed occupational asthma
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Park HS, Kim HY, Suh JH, Nahm DH, Sohn JW, Kim YY
- KMID: 2054846
- J Asthma Allergy Clin Immunol.
- 1999 Aug;19(4):594-600.
BACKGROUND AND OBJECTIVE: TDI is known to be the most prevalent cause of occupational asthma ( OA ) in Korea. However, the pathogenesis of TDI - induced occupational asthma still... -
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- IL-4 and IL-5 Secretions Predominate in the Airways of Wistar Rats Exposed to Toluene Diisocyanate Vapor
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Kouadio K, Zheng KC, Toure AA, Dosso M, Todoriki H
- KMID: 1791969
- J Prev Med Public Health.
- 2014 Jan;47(1):57-63.
OBJECTIVES: We established a Wistar rat model of asthma caused by toluene diisocyanate (TDI) exposure, and investigated the relationship between TDI exposure concentrations and respiratory hypersensitivity, airway inflammation, and cytokine... -
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- Longitudinal study of specific antibodies to toluene diisocyanate (TDI)-human serum albumin (HSA) conjugate in patients with TDI-induced asthma
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Park HS, Lee SK, Lee YM, Kim SS, Nahm DH
- KMID: 759619
- Korean J Intern Med.
- 2002 Dec;17(4):249-251.
BACKGROUND: An appreciable number of patients with toluene diisocyanate (TDI)-induced asthma have high serum levels of specific IgE (sIgE) antibody to TDI-human serum albumin conjugate (HSA). A recent investigation... -
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- Heterogeneity of IgE response to TDI-HSA conjugates by ELISA in toluene diisocyanate (TDI) -induced occupational asthma (OA) patients
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Son M, Lee M, Kim YT, Youn JK, Park H
- KMID: 1064961
- J Korean Med Sci.
- 1998 Apr;13(2):147-152.
- doi: 10.3346/jkms.1998.13.2.147
Toluene diisocyanate (TDI), a low molecular weight reactive chemical, is known to be a main cause of occupational asthma (OA) in Korea. Although it is thought that inhaled TDI... -
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- Toluene diisocyanate inhalation bronchial challenge test with a closed- circuit device
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Hong CS, Park JW, Kim CW, Kang SM, Choi YH
- KMID: 2365359
- Allergy.
- 1995 Dec;15(4):598-610.
Occupational asthma is the most common respiratory disease related to the working environments. Isocyanates, especially toluene diisoeyanate(TDI), are currently the most common cause of occupational asthma both in Korea and... -
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- Epithelial folliculin is involved in airway inflammation in workers exposed to toluene diisocyanate
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Pham DL, Trinh TH, Ban GY, Kim SH, Park HS
- KMID: 2396800
- Exp Mol Med.
- 2017 Nov;49(11):e395.
- doi: 10.1038/emm.2017.180
Toluene diisocyanate (TDI) exposure can directly activate and damage airway epithelium. Folliculin (FLCN) is a protein expressed by human airway epithelial cells (HAECs) to maintain airway epithelial integrity and survival.... -
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- Immunohistochemical characterization of the cellular infiltrate in airway mucosa of toluene diisocyanate (TDI)-induced asthma: comparison with allergic asthma
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Park HS, Hwang SC, Nahm DH, Yim HE
- KMID: 1107221
- J Korean Med Sci.
- 1998 Feb;13(1):21-26.
- doi: 10.3346/jkms.1998.13.1.21
Toluene diisocyanate (TDI) is the most prevalent agent in occupational asthma (OA) in Korea. The immuno-pathologic mechanism for TDI-induced bronchoconstriction remains to be clarified. We studied the immunohistochemical finding of... -
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- Clinical and immunological evaluation of isocyanate-exposed workers
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Park HS, Park JN, Kim JW, Kim SK
- KMID: 1421901
- J Korean Med Sci.
- 1992 Jun;7(2):122-127.
- doi: 10.3346/jkms.1992.7.2.122
Isocyanates are the most significant cause of occupational asthma in our country. To evaluate the prevalence of work-related respiratory symptoms and immunologic sensitization to it, we performed a questionnaire... -
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- Biomarkers Predicting Isocyanate-Induced Asthma
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Palikhe NS, Kim JH, Park HS
- KMID: 2260373
- Allergy Asthma Immunol Res.
- 2011 Jan;3(1):21-26.
- doi: 10.4168/aair.2011.3.1.21
Three diisocyanates can cause occupational asthma (OA): toluene diisocyanate (TDI), 4,4 diphenylmethane diisocyanate (MDI), and 1,6-hexamethylene diisocyanate (HDI). We analyzed potential biomarkers of isocyanate-induced OA, based on investigated immunologic, genetic,... -
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- Serum Periostin Levels: A Potential Serologic Marker for Toluene Diisocyanate-Induced Occupational Asthma
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Lee JH, Kim SH, Choi Y, Trinh HK, Yang EM, Ban GY, Shin YS, Ye YM, Izuhara K, Park HS
- KMID: 2426336
- Yonsei Med J.
- 2018 Dec;59(10):1214-1221.
- doi: 10.3349/ymj.2018.59.10.1214
PURPOSE: Toluene diisocyanate (TDI) is a leading cause of occupational asthma (OA). Periostin is a matricellular protein implicated in type 2 immunity-driven asthma. Its pathogenic role in TDI-OA has not... -
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- Exposure to toluene diisocyanate ( TDI) induces IL - 8 and RANTES production from bronchial epithelial cell
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Park HS, Kim HY, Suh JH, Nahm DH, Kwon OJ, Choi DC
- KMID: 2286004
- J Asthma Allergy Clin Immunol.
- 1999 Dec;19(6):935-941.
BACKGROUND: There have been a few reports suggesting involvement of neutrophil as well as eosinophil in inducing bronchoconstriction aft,er inhalation of TDI. OBJECTIVE: In order to observe the source of... -
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- Expression of Inducible Nitric Oxide Synthase and Its Steroid Effect in TDI-Induced Nasal Hyperreactive Guinea Pigs
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Lee SK, Kang JM, Cho JH, Rhyoo C, Won YS, Yoon HR
- KMID: 2012704
- Korean J Otolaryngol-Head Neck Surg.
- 2000 Jun;43(6):610-614.
BACKGROUND AND OBJECTIVES: Nitric oxide (NO) in exhaled air is elevated in allergy. Topical corticosteroid therapy which has been shown to reduce airway inflammation is associated with reduction in exhaled... -
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