- Toll-like receptor 4 antagonist and obesity associated kidney disease: Where should we go from here?
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Ali Q
- KMID: 2381517
- Kidney Res Clin Pract.
- 2015 Mar;34(1):64-65.
- doi: 10.1016/j.krcp.2014.10.007
No abstract available. -
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- Expression of Toll-Like Receptor 2 and Toll-Like Receptor 4 in Cholesteatoma
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Byun JY, Cha CI, Yeo SG, Lee SK, Cho JS
- KMID: 2276637
- Korean J Otolaryngol-Head Neck Surg.
- 2006 May;49(5):482-487.
BACKGROUND AND OBJECTIVES: One of the hallmarks of aural cholesteatoma is chronic and recurrent infection. Initiation and perpetuation of the inflammatory response of cholesteatoma may result from an exaggerated host... -
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- Lipopolysaccharide: Basic Biochemistry, Intracellular Signaling, and Physiological Impacts in the Gut
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Rhee SH
- KMID: 2284892
- Intest Res.
- 2014 Apr;12(2):90-95.
- doi: 10.5217/ir.2014.12.2.90
Lipopolysaccharide (LPS), a main constituent of Gram-negative bacterial membrane, specifically activates Toll-like receptor 4, leading to the production of pleiotropic cytokines/chemokines which in turn regulate inflammatory and innate and subsequent... -
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- IL-17 and Toll-like Receptor 2 or Toll-like Receptor 4 Combined Engagement Upregulates RANKL and IL-6 in Human Rheumatoid Synovial Fibroblasts
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Kim KW, Lee SH, Cho ML, Oh HJ, Woo YJ, Kim SH, Kim HR
- KMID: 2201990
- J Korean Rheum Assoc.
- 2010 Mar;17(1):36-45.
- doi: 10.4078/jkra.2010.17.1.36
OBJECTIVE: The aim of this study was to clarify whether stimulation of recombinant IL-17, TLR2 and TLR4 by their specific ligands induces the production of RANKL and IL-6 in the... -
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- Decreased expression of Toll-like receptor 4 and 5 during progression of prostate transformation in transgenic adenocarcinoma of mouse prostate mice
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Han JH, Park JH, Kim BY, Chang SN, Kim TH, Park JH, Kim DJ
- KMID: 2344300
- J Vet Sci.
- 2015 Sep;16(3):281-287.
- doi: 10.4142/jvs.2015.16.3.281
Chronic inflammation has been considered an important risk factor for development of prostate cancer. Toll-like receptors (TLRs) recognize microbial moieties or endogenous molecules and play an important role in the... -
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- Systems Biological Approaches Reveal Non-additive Responses and Multiple Crosstalk Mechanisms between TLR and GPCR Signaling
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Krishnan J, Choi S
- KMID: 1806244
- Genomics Inform.
- 2012 Sep;10(3):153-166.
- doi: 10.5808/GI.2012.10.3.153
A variety of ligands differ in their capacity to bind the receptor, elicit gene expression, and modulate physiological responses. Such receptors include Toll-like receptors (TLRs), which recognize various patterns of... -
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- IGF-I Exerts an Anti-inflammatory Effect on Skeletal Muscle Cells through Down-regulation of TLR4 Signaling
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Lee WJ
- KMID: 1449814
- Immune Netw.
- 2011 Aug;11(4):223-226.
- doi: 10.4110/in.2011.11.4.223
Although exercise-induced growth factors such as Insulin-like growth factor-I (IGF-I) are known to affect various aspects of physiology in skeletal muscle cells, the molecular mechanism by which IGF-I modulates anti-inflammatory... -
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- Association Between Toll-Like Receptors/CD14 Gene Polymorphisms and Inflammatory Bowel Disease in Korean Population
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Kim EJ, Chung WC, Lee KM, Paik CN, Jung SH, Lee BI, Chae HS, Choi KY
- KMID: 1792982
- J Korean Med Sci.
- 2012 Jan;27(1):72-77.
- doi: 10.3346/jkms.2012.27.1.72
The innate immune response in patients who develop inflammatory bowel disease (IBD) may be abnormal. However, the exact role of Toll-like receptors (TLRs) / CD14 gene in the pathogenesis of... -
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- Serum amyloid A inhibits RANKL-induced osteoclast formation
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Oh E, Lee HY, Kim HJ, Park YJ, Seo JK, Park JS, Bae YS
- KMID: 2359881
- Exp Mol Med.
- 2015 Nov;47(11):e194.
- doi: 10.1038/emm.2015.83
When mouse bone marrow-derived macrophages were stimulated with serum amyloid A (SAA), which is a major acute-phase protein, there was strong inhibition of osteoclast formation induced by the receptor activator... -
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- Association of Toll-Like Receptor Gene with Crohn's Disease in Koreans
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Ye BD, Yang SK, Song K, Yang DH, Yoon SM, Kim KJ, Byeon JS, Myung SJ, Kim JH
- KMID: 1775937
- Korean J Gastroenterol.
- 2009 Dec;54(6):377-383.
- doi: 10.4166/kjg.2009.54.6.377
BACKGROUND/AIMS: Toll-like receptors (TLRs) serve as pattern recognition receptors that recognize specific molecular patterns of pathogens and can mediate the production of proinflammatory cytokines. Recently, TLRs have been identified as... -
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- Fusobacterium nucleatum GroEL signaling via Toll-like receptor 4 in human microvascular endothelial cells
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Lee HR, Choi BK
- KMID: 1436486
- Int J Oral Biol.
- 2012 Sep;37(3):130-136.
The GroEL heat-shock protein from Fusobacterium nucleatum, a periodontopathogen, activates risk factors for atherosclerosis in human microvascular endothelial cells (HMEC-1) and ApoE-/- mice. In this study, we analyzed the signaling... -
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- Expression of TLR-4 in epithelial serous ovarian cancer
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Choi CH, Lee JW, Choi JJ, Kim WY, Kim TJ, Lee JH, Kim BG, Bae DS
- KMID: 2244546
- Korean J Gynecol Oncol.
- 2007 Sep;18(3):180-186.
OBJECTIVE: This study was to determine the expression of Toll-like receptor 4 (TLR-4) in ovarian serous adenocarcinoma tissues. METHODS: TLR-4 expression was evaluated at the RNA level by real-time quantitative RT-PCR,... -
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- Recognition of lipopolysaccharide pattern by TLR4 complexes
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Park BS, Lee JO
- KMID: 2154285
- Exp Mol Med.
- 2013 Dec;45(12):e66.
Lipopolysaccharide (LPS) is a major component of the outer membrane of Gram-negative bacteria. Minute amounts of LPS released from infecting pathogens can initiate potent innate immune responses that prime the... -
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- Lack of Toll-like Receptor 4 and 2 Polymorphisms in Korean Patients with Bacteremia
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Yoon HJ, Choi JY, Kim CO, Park YS, Kim MS, Kim YK, Shin SY, Kim JM, Song YG
- KMID: 1713104
- J Korean Med Sci.
- 2006 Dec;21(6):979-982.
- doi: 10.3346/jkms.2006.21.6.979
Toll-like receptors (TLRs) are pattern-recognition receptors that are important in innate immune responses to bacterial infection. The purpose of this study is to describe the prevalence of TLRs genetic variations... -
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- Expression of Toll-like Receptor 4 on Human Keratinocytes by Lipoteichoic Acid
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Park YM, Kwon HJ, Kang YS, Koo JK, Kim MY, Kim HO, Song PI, Armstrong , Ansel JC
- KMID: 2302347
- Korean J Dermatol.
- 2006 Jan;44(1):15-21.
BACKGROUND: We have recently shown that lipopolysaccharide (LPS), a major biologically active component of Gram-negative bacteria, mediate the activation of human keratinocytes by CD14 and Toll-like receptor (TLR 4). However,... -
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- Carnosic acid inhibits TLR4-MyD88 signaling pathway in LPS-stimulated 3T3-L1 adipocytes
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Park MY, Mun ST
- KMID: 2313772
- Nutr Res Pract.
- 2014 Oct;8(5):516-520.
- doi: 10.4162/nrp.2014.8.5.516
BACKGROUND/OBJECTIVES: Carnosic acid (CA), found in rosemary (Rosemarinus officinalis) leaves, is known to exhibit anti-obesity and anti-inflammatory activities. However, whether its anti-inflammatory potency can contribute to the amelioration of obesity... -
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- Toll-like receptor 4 on islet beta cells senses expression changes in high-mobility group box 1 and contributes to the initiation of type 1 diabetes
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Li M, Song L, Gao X, Chang W, Qin X
- KMID: 1365903
- Exp Mol Med.
- 2012 Apr;44(4):260-267.
- doi: 10.3858/emm.2012.44.4.021
Type 1 diabetes mellitus is caused by the autoimmune destruction of beta cells within the islets. In recent years, innate immunity has been proposed to play a key role in... -
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- New Era of Post Urinary Tract Infection Pain Syndrome
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Lee KW, Kim YH
- KMID: 2350756
- Urogenit Tract Infect.
- 2016 Aug;11(2):49-55.
- doi: 10.14777/uti.2016.11.2.49
Urinary tract infection (UTI) in most cases is accompanied by pain. However, in some cases, including asymptomatic bacteriuria (ASB), pain is absent and thus, cannot be characterized. A study with... -
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- Diallyl Trisulfide Suppresses the Production of Lipopolysaccharide-induced Inflammatory Mediators in BV2 Microglia by Decreasing the NF-κB Pathway Activity Associated With Toll-like Receptor 4 and CXCL12/CXCR4 Pathway Blockade
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Lee HH, Jeong JW, Hong SH, Park C, Kim BW, Choi YH
- KMID: 2425316
- J Cancer Prev.
- 2018 Sep;23(3):134-140.
- doi: 10.15430/JCP.2018.23.3.134
BACKGROUND: Diallyl trisulfide (DATS), a garlic-derived organosulfuric compound, has been documented for potential anti-inflammatory effects. However, the mechanism in microglia remains unknown. In this study, we investigated the anti-inflammatory effects... -
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- Pyrrolidine Dithiocarbamate Inhibits Nuclear Factor kappaB and Toll-Like Receptor 4 Expression in Rats with Acute Necrotizing Pancreatitis
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Xu M, Wang KN, Wu K, Wang XP
- KMID: 2155650
- Gut Liver.
- 2015 May;9(3):411-416.
- doi: 10.5009/gnl14050
BACKGROUND/AIMS: To investigate the expression of Toll-like receptor 4 (TLR4) in the pancreases of rats with acute necrotizing pancreatitis (ANP) and any changes upon treatment with pyrrolidine dithiocarbamate (PDTC), an... -
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