- Targeting Microglial and Neuronal Toll-like Receptor 2 in Synucleinopathies
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Kwon S, Iba M, Masliah E, Kim C
- KMID: 2463710
- Exp Neurobiol.
- 2019 Oct;28(5):547-553.
- doi: 10.5607/en.2019.28.5.547
Synucleinopathies are neurodegenerative disorders characterized by the progressive accumulation of α-synuclein (α-syn) in neurons and glia and include Parkinson's disease (PD) and dementia with Lewy bodies (DLB). In this review,... -
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- Expression of Toll-Like Receptor 2 and Toll-Like Receptor 4 in Cholesteatoma
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Byun JY, Cha CI, Yeo SG, Lee SK, Cho JS
- KMID: 2276637
- Korean J Otolaryngol-Head Neck Surg.
- 2006 May;49(5):482-487.
BACKGROUND AND OBJECTIVES: One of the hallmarks of aural cholesteatoma is chronic and recurrent infection. Initiation and perpetuation of the inflammatory response of cholesteatoma may result from an exaggerated host... -
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- Expression of Toll-like Receptor 2 in Cultured Human Keratinocytes: The Effect of Bacterial Antigens, Cytokines and Calcium Concentration
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Lew BL, Sim WY, Kim NI
- KMID: 2156494
- Ann Dermatol.
- 2009 Nov;21(4):337-344.
- doi: 10.5021/ad.2009.21.4.337
BACKGROUND: Toll-like receptors (TLRs) are expressed by human epidermal keratinocytes and are involved in immune responses. OBJECTIVE: The goal of this was to investigate the expression of TLR2 in response to... -
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- Non-cell-autonomous Neurotoxicity of α-synuclein Through Microglial Toll-like Receptor 2
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Kim C, Lee HJ, Masliah E, Lee SJ
- KMID: 2308636
- Exp Neurobiol.
- 2016 Jun;25(3):113-119.
- doi: 10.5607/en.2016.25.3.113
Synucleinopathies are a collection of neurological diseases that are characterized by deposition of α-synuclein aggregates in neurons and glia. These diseases include Parkinson's disease (PD), dementia with Lewy bodies, and... -
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- Toll-like Receptor 2: A Novel Therapeutic Target for Ischemic White Matter Injury and Oligodendrocyte Death
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Choi JY, Kim BG
- KMID: 2389005
- Exp Neurobiol.
- 2017 Aug;26(4):186-194.
- doi: 10.5607/en.2017.26.4.186
Despite paramount clinical significance of white matter stroke, there is a paucity of researches on the pathomechanism of ischemic white matter damage and accompanying oligodendrocyte (OL) death. Therefore, a large... -
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- IL-17 and Toll-like Receptor 2 or Toll-like Receptor 4 Combined Engagement Upregulates RANKL and IL-6 in Human Rheumatoid Synovial Fibroblasts
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Kim KW, Lee SH, Cho ML, Oh HJ, Woo YJ, Kim SH, Kim HR
- KMID: 2201990
- J Korean Rheum Assoc.
- 2010 Mar;17(1):36-45.
- doi: 10.4078/jkra.2010.17.1.36
OBJECTIVE: The aim of this study was to clarify whether stimulation of recombinant IL-17, TLR2 and TLR4 by their specific ligands induces the production of RANKL and IL-6 in the... -
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- Association Between Toll-Like Receptors/CD14 Gene Polymorphisms and Inflammatory Bowel Disease in Korean Population
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Kim EJ, Chung WC, Lee KM, Paik CN, Jung SH, Lee BI, Chae HS, Choi KY
- KMID: 1792982
- J Korean Med Sci.
- 2012 Jan;27(1):72-77.
- doi: 10.3346/jkms.2012.27.1.72
The innate immune response in patients who develop inflammatory bowel disease (IBD) may be abnormal. However, the exact role of Toll-like receptors (TLRs) / CD14 gene in the pathogenesis of... -
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- Toll-like receptor 2 expression on monocytes from patients with BCG vaccine-associated suppurative lymphadenitis
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Oh HJ, Shin KS
- KMID: 2281071
- Korean J Pediatr.
- 2009 Jun;52(6):667-673.
- doi: 10.3345/kjp.2009.52.6.667
PURPOSE: Toll-like receptor 2 (TLR2) is critical in the immune response to mycobacterial infections. The purpose of this study was to analyze TLR2 surface expressions and TLR2-mediated tumor necrosis factor-alpha... -
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- Serum amyloid A inhibits RANKL-induced osteoclast formation
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Oh E, Lee HY, Kim HJ, Park YJ, Seo JK, Park JS, Bae YS
- KMID: 2359881
- Exp Mol Med.
- 2015 Nov;47(11):e194.
- doi: 10.1038/emm.2015.83
When mouse bone marrow-derived macrophages were stimulated with serum amyloid A (SAA), which is a major acute-phase protein, there was strong inhibition of osteoclast formation induced by the receptor activator... -
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- Toll-like Receptor 2 is Dispensable for an Immediate-early Microglial Reaction to Two-photon Laser-induced Cortical Injury In vivo
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Yoon H, Jang YH, Kim SJ, Lee SJ, Kim SK
- KMID: 2285591
- Korean J Physiol Pharmacol.
- 2015 Sep;19(5):461-465.
- doi: 10.4196/kjpp.2015.19.5.461
Microglia, the resident macrophages in the central nervous system, can rapidly respond to pathological insults. Toll-like receptor 2 (TLR2) is a pattern recognition receptor that plays a fundamental role in... -
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- Alternaria Induces Production of Thymic Stromal Lymphopoietin in Nasal Fibroblasts Through Toll-like Receptor 2
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Shin SH, Kim YH, Jin HS, Kang SH
- KMID: 2166653
- Allergy Asthma Immunol Res.
- 2016 Jan;8(1):63-68.
- doi: 10.4168/aair.2016.8.1.63
PURPOSE: Chronic rhinosinusitis with nasal polyps is a chronic inflammatory disease with markedly increased eosinophils, Th2-type lymphocytes, fibroblasts, and goblet cells. Fungi are commonly associated with airway inflammatory diseases, and... -
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- The Effect of Toll-like Receptor 2 Activation on the Non-opsonic Phagocytosis of Oral Bacteria and Concomitant Production of Reactive Oxygen Species by Human Neutrophils
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Kim KY, Choi Y
- KMID: 2162142
- Int J Oral Biol.
- 2016 Mar;41(1):17-23.
- doi: 10.11620/IJOB.2016.41.1.017
Chronic/cyclic neutropenia, leukocyte adhesion deficiency syndrome, Papillon-Lefèvre syndrome, and Chédiak-Higashi syndrome are associated with severe periodontitis, suggesting the importance of neutrophils in the maintenance of periodontal health. Various Toll-like receptor... -
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- Lack of Toll-like Receptor 4 and 2 Polymorphisms in Korean Patients with Bacteremia
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Yoon HJ, Choi JY, Kim CO, Park YS, Kim MS, Kim YK, Shin SY, Kim JM, Song YG
- KMID: 1713104
- J Korean Med Sci.
- 2006 Dec;21(6):979-982.
- doi: 10.3346/jkms.2006.21.6.979
Toll-like receptors (TLRs) are pattern-recognition receptors that are important in innate immune responses to bacterial infection. The purpose of this study is to describe the prevalence of TLRs genetic variations... -
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- Rifampicin Inhibits the LPS-induced Expression of Toll-like Receptor 2 via the Suppression of NF-kappaB DNA-binding Activity in RAW 264.7 Cells
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Kim SK, Kim YM, Yeum CE, Jin SH, Chae GT, Lee SB
- KMID: 2285384
- Korean J Physiol Pharmacol.
- 2009 Dec;13(6):475-482.
- doi: 10.4196/kjpp.2009.13.6.475
Rifampicin is a macrocyclic antibiotic which is used extensively for treatment against Mycobacterium tuberculosis and other mycobacterial infections. Recently, a number of studies have focused on the immune-regulatory effects of... -
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- Association of Toll-like receptor 2-positive monocytes with coronary artery lesions and treatment nonresponse in Kawasaki disease
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Kang SJ, Kim NS
- KMID: 2387769
- Korean J Pediatr.
- 2017 Jul;60(7):208-215.
- doi: 10.3345/kjp.2017.60.7.208
PURPOSE: Activation of Toll-like receptor 2 (TLR2) present on circulating monocytes in patients with Kawasaki disease (KD) can lead to the production of proinflammatory cytokines and interleukin-10 (IL-10). We aimed... -
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- Lack of the Association between Microsatellite Polymorphism in Toll-like Receptor 2 Gene and Development of COPD
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Lee HS, Lee HW, Kim DK, Ko DS, Park GM, Hwang YI, Lee SM, Yoo CG, Kim YW, Han SK, Shim YS, Yim JJ
- KMID: 2318549
- Tuberc Respir Dis.
- 2005 Apr;58(4):367-374.
BACKGROUND: The fact that only 10-20% of chronic cigarette smokers develop chronic obstructive pulmonary disease (COPD) reflects the presence of genetic factors associated with the susceptibility to COPD. Recently, it... -
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- The effect of TLR2 mutation in IL-12 production according to type of leprosy
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Kang TJ, Lee SB, Chae GT
- KMID: 1609918
- Korean Lepr Bull.
- 2001 Dec;34(2):3-12.
Recently, many reports suggest that the activation of Toll-like receptor 2 (TLR2) by microbial lipoproteins may initiate innate defense mechanism against infectious pathogens. Especially, TLR2 is critical in the immune... -
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- Role of Toll-like Receptor 2 in a Mouse Model of Allergic Rhinitis
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Kang JM, Cho JH, Song CE, Park CS, Kim BG, Kim SW, Lee JH, Choi SH
- KMID: 1875443
- Korean J Otorhinolaryngol-Head Neck Surg.
- 2007 Nov;50(11):989-995.
BACKGROUND AND OBJECTIVES: Mammalian Toll-like receptors (TLR) participate in innate immune responses to microbial pathogens. Recent interest has been focused on the concept that TLR-induced innate responses can modulate subsequent... -
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- Toll-like receptor 2 promotes neurogenesis from the dentate gyrus after photothrombotic cerebral ischemia in mice
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Seong KJ, Kim HJ, Cai B, Kook MS, Jung JY, Kim WJ
- KMID: 2410104
- Korean J Physiol Pharmacol.
- 2018 Mar;22(2):145-153.
- doi: 10.4196/kjpp.2018.22.2.145
The subgranular zone (SGZ) of hippocampal dentate gyrus (HDG) is a primary site of adult neurogenesis. Toll-like receptors (TLRs), are involved in neural system development of Drosophila and innate immune... -
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- Peptidoglycan Induces the Production of Interleukin-8 via Calcium Signaling in Human Gingival Epithelium
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Son A, Shin DM, Hong JH
- KMID: 2071819
- Korean J Physiol Pharmacol.
- 2015 Jan;19(1):51-57.
- doi: 10.4196/kjpp.2015.19.1.51
The etiology of periodontal disease is multifactorial. Exogenous stimuli such as bacterial pathogens can interact with toll-like receptors to activate intracellular calcium signaling in gingival epithelium and other tissues. The... -
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