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Immunomodulation for Tissue Repair and Regeneration

Moon S, Hong J, Go S, Kim BS

Various immune cells participate in repair and regeneration following tissue injury or damage, orchestrating tissue inflammation and regeneration processes. A deeper understanding of the immune system’s involvement in tissue repair...
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Relationship between Tissue Regeneration and Immune Modulation

Yun CH

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Nanomaterial-Based Scaffolds for Tissue Engineering Applications: A Review on Graphene, Carbon Nanotubes and Nanocellulose

Kandhola G, Park S, Lim JW, Chivers C, Song YH, Chung JH, Kim J, Kim JW

Nanoscale biomaterials have garnered immense interest in the scientific community in the recent decade. This review specifically focuses on the application of three nanomaterials, i.e., graphene and its derivatives (graphene...
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MMP13-Overexpressing Mesenchymal Stem Cells Enhance Bone Tissue Formation in the Presence of Collagen Hydrogel

Arai Y, Lee SH

BACKGROUND: Matrix metalloproteinases (MMPs) are proteins involved in the repair and remodeling the extracellular matrix (ECM). MMP13 is essential for bone development and healing through the remodeling of type I...
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Remodeling and Restraining Lung Tissue Damage Through the Regulation of Respiratory Immune Responses

Pyung YJ, Park DJ, Kim CG, Yun CH

Tissue damage caused by various stimuli under certain conditions, such as biological and environmental cues, can actively induce systemic and/or local immune responses. Therefore, understanding the immunological perspective would be...
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CBX7 Rejuvenates Late Passage Dental Pulp Stem Cells by Maintaining Stemness and Pro-angiogenic Ability

Wu Y, Li B, Yu D, Zhou Z, Shen M, Jiang F

BACKGROUND: Ever-growing tissue regeneration causes pressing need for large population of stem cells. However, extensive cell expansion eventually leads to impaired regenerative potentials. In this study, chromobox protein homolog 7...
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Nanoparticle-Based Chimeric Antigen Receptor Therapy for Cancer Immunotherapy

Shin S, Lee P, Han J, Kim SN, Lim J, Park DH, Paik T, Min J, Park CG, Park W

Adoptive cell therapy with chimeric antigen receptor (CAR)-engineered T cells (CAR-Ts) has emerged as an innovative immunotherapy for hematological cancer treatment. However, the limited effect on solid tumors, complex processes,...
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Schisandrin B Improves the Hypothermic Preservation of Celsior Solution in Human Umbilical Cord Mesenchymal Stem Cells

Zhang Y, Wang P, Jin Mx, Zhou Yq, Ye L, Zhu Xj, Li Hf, Zhou M, Li Y, Li S, Liang Ky, Wang Y, Gao Y, Pan Mx, Zhou Sq, Peng Q

BACKGROUND: Human umbilical cord mesenchymal stem cells (hUCMSCs) have emerged as promising therapy for immune and inflammatory diseases. However, how to maintain the activity and unique properties during cold storage...
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Intestinal Peyer’s Patches: Structure, Function, and In Vitro Modeling

Park JI, Cho SW, Kang JH, Park TE

BACKGOUND: Considering the important role of the Peyer’s patches (PPs) in gut immune balance, understanding of the detailed mechanisms that control and regulate the antigens in PPs can facilitate the...
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Enhancement of Immune Responses Elicited by Nanovaccines through a Cross-Presentation Pathway

Kim CG, Lee JC, Ju DB, Kim SK, Yun CH, Cho CS

Numerous studies have aimed to develop novel advanced vaccines, in part because traditional vaccines have been unsuccessful in preventing rapidly emerging and reemerging viral and bacterial infections. There is a...
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The Intrinsic Relation between the Hydrogel Structure and In Vivo Performance of Hyaluronic Acid Dermal Fillers: A Comparative Study of Four Typical Dermal Fillers

Zhou W, Hou S, Deng S, Peng Y, Fu W, Zhou Y, Yang J, Peng C

BACKGROUND: Hyaluronic acid dermal fillers are composed of cross-linked viscoelastic particles with high biocompatibility. The performance of the fillers is determined by the viscoelastic properties of particles and the connecting...
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Inhibition of Toll-Like Receptor 4 Signaling Pathway Accelerates the Repair of Avascular Necrosis of Femoral Epiphysis through Regulating Macrophage Polarization in Perthes Disease

Yu R, Ma C, Li G, Xu J, Feng D, Lan X

BACKGROUND: Legg-Calvé-Perthes disease (LCPD) is still a refractory disease in children’s orthopedics. With the introduction of the concept of ‘‘osteoimmunology’’, the immune-inflammatory mechanisms between bone and immune system have become...
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Pathological Characteristics of Monosodium Iodoacetate-Induced Osteoarthritis in Rats

Kwon M, Nam D, Kim J

BACKGROUND: This study aimed to identify pain-related behavior and pathological characteristics of the knee joint in rats with monosodium iodoacetate (MIA)-induced osteoarthritis (OA). METHODS: Knee joint inflammation was induced by intra-articular...
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