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Research Progress of Three-Dimensional Bioprinting Artificial Cardiac Tissue

Mao X, Wang Z

Cardiovascular disease is one of the main diseases that endanger human life and health, and heart failure often occurs when the cardiovascular disease develops to the end-stage. Heart transplantation is...
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Laser-Structured Si and PLGA Inhibit the Neuro2a Differentiation in Mono- and Co-Culture with Glia

Angelaki D, Kavatzikidou P, Fotakis C, Stratakis E, Ranella A

BACKGROUND: The first step towards a successful neural tissue engineering therapy is the development of an appropriate scaffold and the in vitro study of the cellular response onto it. METHODS: Here,...
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Combinatorial Effect of Mesenchymal Stem Cells and Extracellular Vesicles in a Hydrogel on Cartilage Regeneration

Cho WJ, Ahn J, Lee M, Choi H, Park S, Cha KY, Lee S, Arai Y, Lee SH

BACKGROUND: Mesenchymal stem cells (MSCs) are used for tissue regeneration due to their wide differentiation capacity and anti-inflammatory effects. Extracellular vesicles (EVs) derived from MSCs are also known for their...
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Immunomodulatory Biomaterials and Emerging Analytical Techniques for Probing the Immune Micro-Environment

Bian N, Chu C, Rung S, Huangphattarakul V, Man Y, Lin J, Hu C

After implantation of a biomaterial, both the host immune system and properties of the material determine the local immune response. Through triggering or modulating the local immune response, materials can...
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Towards Clinical Translation of In Situ Cartilage Engineering Strategies: Optimizing the Critical Facets of a Cell-Laden Hydrogel Therapy

Duchi S, Francis SL, Onofrillo C, O’Connell CD, Choong P, Bella CD

BACKGROUND: Articular cartilage repair using implantable photocrosslinkable hydrogels laden with chondrogenic cells, represents a promising In Situ cartilage engineering approach for surgical treatment. The development of a surgical procedure requires...
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Combined Application of Dentin Noncollagenous Proteins and Odontogenic Biphasic Calcium Phosphate in Rabbit Maxillary Sinus Lifting

Yang G, Liu X, Huang T, Ding R, Wang Y

BACKGROUND: Teeth can be used as a raw material for preparing bone substitutes due to their similar chemical composition to bone. The objective of our study was to evaluate the...
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Vessel-Derived Decellularized Extracellular Matrices (VdECM): Novel Bio-Engineered Materials for the Wound Healing

Lee CR, Lee YJ, Kwon BY, Lee SJ, Ryu YH, Rhie JW, Moon SH

BACKGROUND: Decellularized extracellular matrix (dECM) is a non-cellular scaffold with various functions in tissue engineering and regenerative medicine. Elastin is related to tissue elasticity and scarless wound healing, abundantly found...
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rhBMP-2-Conjugated Three-Dimensional-Printed Poly(L-lactide) Scaffold is an Effective Bone Substitute

Hong YR, Kim TH, Park KH, Kang J, Lee K, Park EK, Kwon TG, Lim JO, Oh CW

BACKGROUND: Bone growth factors, particularly bone morphogenic protein-2 (BMP-2), are required for effective treatment of significant bone loss. Despite the extensive development of bone substitutes, much remains to be desired...
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Anti-Osteoarthritic Effects of Cartilage-Derived Extracellular Matrix in a Rat Osteoarthritis Model

Lee SH, Jo SH, Kim SH, Kim CS, Park SH

BACKGROUND: The extracellular matrix (ECM) has many functions, such as segregating tissues, providing support, and regulating intercellular communication. Cartilage-derived ECM (CECM) can be prepared via consecutive processes of chemical decellularization...
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A Comparative Systematic Analysis of The Influence of Microplastics on Colon Cells, Mouse and Colon Organoids

Park SB, Jung WH, Choi KJ, Koh B, Kim KY

BACKGROUND: Microplastics (MPs) are small fragments from any type of plastic formed from various sources, including plastic waste and microfibers from clothing. MPs degrades slowly, resulting in a high probability...
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Comparative Study of Two Common In Vitro Models for the Pancreatic Islet with MIN6

Chao X, Zhao F, Hu J, Yu Y, Xie R, Zhong J, Huang M, Zeng T, Yang H, Luo D, Peng W

BACKGROUND: Islet transplantation is currently considered the most promising method for treating insulin-dependent diabetes. The two most-studied artificial islets are alginate-encapsulated b cells or b cell spheroids. As three-dimensional (3D)...
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