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Applications of Bacterial Cellulose-Based Composite Materials in Hard Tissue Regenerative Medicine

Liu Y, Liu H, Guo S, Qi J, Zhang R, Liu X, Sun L, Zong M, Cheng H, Wu X, Li B

BACKGROUND: Cartilage, bone, and teeth, as the three primary hard tissues in the human body, have a significant application value in maintaining physical and mental health. Since the development of...
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A Review of the Role of Bioreactors for iPSCs-Based TissueEngineered Articular Cartilage

Reina-Mahecha A, Beers MJ, Veen HCvd, Zuhorn IS, Kooten TGv, Sharma PK

BACKGROUND: Osteoarthritis (OA) is the most common degenerative joint disease without an ultimate treatment. In a search for novel approaches, tissue engineering (TE) has shown great potential to be an...
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Generation of Connective Tissue-Free Microvascular Fragment Isolates from Subcutaneous Fat Tissue of Obese Mice

Meßner FC, Metzger W, Marschall JE, Bickelmann C, Menger MD, Laschke MW

BACKGROUND: Microvascular fragment (MVF) isolates are generated by short-term enzymatic digestion of adipose tissue and contain numerous vessel segments for the vascularization of tissue defects. Recent findings indicate that the...
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Correction to: Nitrosylation of b2-Tubulin Promotes Microtubule Disassembly and Differentiated Cardiomyocyte Beating in Ischemic Mice

Choi DH, Kang SK, Lee KE, Jung J, Kim EJ, Kim WH, Kwon YG, Kim KP, Jo I, Park YS, Park SI

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Deep Learning Model for Predicting Airway Organoid Differentiation

Lim MH, Shin S, Park K, Park J, Kim SW, Basurrah MA, Lee S, Kim DH

BACKGROUND: Organoids are self-organized three-dimensional culture systems and have the advantages of both in vitro and in vivo experiments. However, each organoid has a different degree of self-organization, and methods...
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AuNP-Loaded Electrospinning Membrane Cooperated with CDs for Periodontal Tissue Engineering

Wang J, Zhang H, Wang Y, Liu X, Zhu W, Jiang F, Li S, Liu L

BACKGROUND: Guided bone regeneration (GBR) is commonly used to regenerate periodontal tissue. However, the bone inductivity and antibacterial properties of the GBR membranes currently in use are severely limited. This...
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The Effects of Injectable Platelet-Rich Fibrin and AdvancedPlatelet Rich Fibrin on Gingival Fibroblast Cell Vitality, Proliferation, Differentiation

Ashour SH, Mudalal M, Al-Aroomi OA, Al-Attab R, Li W, Yin L

BACKGROUND: Injectable Platelet Rich Fibrin (I-PRF) and Advanced-Platelet Rich Fibrin (A-PRF) are autologous materials derived from patients’ blood and employed in periodontal regenerative surgery. Although I-PRF and A-PRF have different...
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Bioactive Bone Substitute in a Rabbit Ulna Model: Preclinical Study

Hong YR, Kim TH, Lee K, Lim JO, Oh CW

BACKGROUND: Current therapies to effectively treat long-bone defects and extensive bone tissue loss remains limited. In this study, we created a new bone substitute by integrating advanced technologies such as structure...
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Delivery of SAV-siRNA via Exosomes from Adipose-Derived Stem Cells for the Treatment of Myocardial Infarction

Bai W, Zhu T, Zuo J, Li Y, Huang X, Li G

BACKGROUND: Myocardial infarction (MI) leads to cardiomyocyte death, poor cardiac remodeling, and heart failure, making it a major cause of mortality and morbidity. To restore cardiac pumping function, induction of...
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circ_SPEF2 Regulates the Balance of Treg Cells by Regulating miR-16-5p/BACH2 in Lymphoma and Participates in the Immune Response

Zhou J, Xu M, Chen Z, Huang L, Wu Z, Huang Z, Liu L

BACKGROUND: This study aims to explore the potential mechanism of action of the newly discovered hsa_-circ_0128899 (circSPEF2) in diffuse large B-cell lymphoma (DLBCL). METHODS: circSPEF2, miR-16-5p and BTB and CNC homologue...
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Protection of the Vascular System by Polyethylene Glycol Reduces Secondary Injury Following Spinal Cord Injury in Rats

Lee J, Hahm SC, Yoo H, Yoon YW, Kim J

BACKGROUND: Polyethylene glycol (PEG) is a hydrophilic polymer, which has been known to have a neuroprotective effect by sealing the ruptured cell membrane, but PEG effects on the vascular systems...
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Development of an In Vitro Model for Inflammation Mediated Renal Toxicity Using 3D Renal Tubules and Co-Cultured Human Immune Cells

Kyun Ml, Park T, Jung H, Kim I, Kwon JI, Jeong SY, Choi M, Park D, Lee YB, Moon KS

BACKGROUND: The emergence of various infectious diseases and the toxic effects of hyperinflammation by biotherapeutics have highlighted the need for in vitro preclinical models mimicking the human immune system. In...
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Proliferation-Related Features of the Human Mesenchymal Stem Cells Derived from Palatine Tonsils, Adipose Tissues, and Bone Marrow

Park S, Yu Y, Park GC, Shin SC, Kim JM, Lee BJ, Kim YH

BACKGROUND: Mesenchymal stem cells (MSCs) are widely used in regenerative medicine and cell-based transplantations. However, an in-depth comparison of the different MSC origins is lacking. This study aimed to compare...
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Enhancing Viability of Human Embryonic Stem Cells during Cryopreservation via RGD-REP-Mediated Activation of FAK/AKT/FoxO3a Signaling Pathway

Kim JH, Choi JI, Che YH, Sung SH, Lee H, Lee S, Park JH, Lee YI, Lee YS, Jeon WB, Kim YJ

BACKGROUND Cryopreservation is a crucial method for long-term storage and stable allocation of human pluripotent stem cells (hPSCs), which are increasingly being used in various applications. However, preserving hPSCs in...
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Effectiveness of Mesenchymal Stem Cell Secretome on Wound Healing: A Systematic Review and Meta-analysis

Suhandi C, Mohammed AFA, Wilar G, El-Rayyes A, Wathoni N

BACKGROUND: Secretome provides promising potential in replacing cell-based therapies in wound repair therapy. This study aimed to systematically review and conduct a meta-analysis on the effectiveness of secretome in promoting...
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