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The Concept of Early Osteoarthritis and Its Significance in Regenerative Medicine

Im GI

Osteoarthritis (OA) has been investigated as one of important target diseases for regenerative medicine. The concept of early OA has recently emerged under the assumption that if OA is detected...
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Use of Human Gingival Fibroblasts for Pre-Vascularization Strategies in Oral Tissue Engineering

Smirani R, Rémy M, Devillard R, Naveau A

BACKGROUND: Cocultures of human gingival fibrobasts (hGF) and endothelial cells could enhance regeneration and repair models as well as improve vascularization limitations in tissue engineering. The aim of this study...
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Fat Graft with Allograft Adipose Matrix and Magnesium Hydroxide-Incorporated PLGA Microspheres for Effective Soft Tissue Reconstruction

Kim DH, Kim DS, Ha HJ, Jung JW, Baek SW, Baek SH, Kim TH, Lee JC, Hwang E, Han DK

BACKGROUND: Autologous fat grafting is one of the most common procedures used in plastic surgery to correct soft tissue deficiency or depression deformity. However, its clinical outcomes are often suboptimal,...
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Regenerative Potential of Platelet Rich Fibrin (PRF) in Socket Preservation in Comparison with Conventional Treatment Modalities: A Systematic Review and Meta-Analysis

Alrayyes Y, Al-Jasser R

BACKGROUND Platelet rich fibrin (PRF) has shown great potential in osteogenesis; however, some studies still question utilizing it as a grafting material. Thus, the aim of this review is to...
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The Biocompatibility of Multi-Source Stem Cells and GelatinCarboxymethyl Chitosan-Sodium Alginate Hybrid Biomaterials

Wang X, Li S, Yu H, Lv J, Fan M, Wang X, Wang X, Liang Y, Mao L, Zhao Z

BACKGROUND: Nowadays, biological tissue engineering is a growing field of research. Biocompatibility is a key indicator for measuring tissue engineering biomaterials, which is of great significance for the replacement and...
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Thermosensitive Hydrogel Loaded with Primary ChondrocyteDerived Exosomes Promotes Cartilage Repair by Regulating Macrophage Polarization in Osteoarthritis

Sang X, Zhao X, Yan L, Jin X, Wang X, Wang J, Yin Z, Zhang Y, Meng Z

BACKGROUND: Intra-articular injection is a classic strategy for the treatment of early osteoarthritis (OA). However, the local delivery of traditional therapeutic agents has limited benefits for alleviating OA. Exosomes, an...
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Heparin Immobilization of Tissue Engineered Xenogeneic Small Diameter Arterial Scaffold Improve Endothelialization

Tardalkar K, Marsale T, Bhamare N, Kshersagar J, Chaudhari L, Joshi MG

BACKGROUND: Autologous vessels graft (Inner diameter \ 6 mm) harvesting always challenged during bypass grafting surgery and its complication shows poor outcome. Tissue engineered vascular graft allow to generate biological...
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Isolation of High Purity Mouse Mesenchymal Stem Cells through Depleting Macrophages Using Liposomal Clodronate

Song JH, Kim JW, Lee MN, Oh SH, Piao X, Wang Z, Kwon SH, Kim OS, Koh JT

BACKGROUND: The use of mouse bone marrow mesenchymal stem cells (mBMSCs) represents a promising strategy for performing preclinical studies in the field of cell-based regenerative medicine; however, mBMSCs obtained via...
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The Progress of Decellularized Scaffold in Stomatology

Zeng A, Li H, Liu J, Wu M

The oral and maxillofacial region contains oral organs and facial soft tissues. Due to the complexity of the structures and functions of this region, the repair of related defects is...
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Improvement of IgA Nephropathy and Kidney Regeneration by Functionalized Hyaluronic Acid and Gelatin Hydrogel

Khunmanee S, Khunmanee S, Chun SY, Ha YS, Lee JN, Kim BS, Gao WW, Kim IY, Han DK, You S, Kwon TG, Park H

BACKGROUND: Immunoglobulin A (IgA) nephropathy (IgAN) is one of an important cause of progressive kidney disease and occurs when IgA settles in the kidney resulted in disrupts kidney’s ability to...
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Improvement of IgA Nephropathy and Kidney Regeneration by Functionalized Hyaluronic Acid and Gelatin Hydrogel

Khunmanee S, Chun SY, Ha YS, Lee JN, Kim BS, Gao WW, Kim IY, Han DK, You S, Kwon TG, Park H

BACKGROUND: Immunoglobulin A (IgA) nephropathy (IgAN) is one of an important cause of progressive kidney disease and occurs when IgA settles in the kidney resulted in disrupts kidney’s ability to...
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A Comparative Study of an Anti-Thrombotic Small-Diameter Vascular Graft with Commercially Available e-PTFE Graft in a Porcine Carotid Model

Lee KS, Kayumov M, Emechebe GA, Kim DW, Cho HJ, Jeong YJ, Lee DW, Park JK, Park CH, Kim CS, Obiweluozor FO, Jeong IS

BACKGROUND: We have designed a reinforced drug-loaded vascular graft composed of polycaprolactone (PCL) and polydioxanone (PDO) via a combination of electrospinning/3D printing approaches. To evaluate its potential for clinical application,...
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Gymnemic Acid Ameliorates Pancreatic β-Cell Dysfunction by Modulating Pdx1 Expression: A Possible Strategy for β-Cell Regeneration

Kannan P, Raghunathan M, Mohan T, Palanivelu S, Periandavan K

BACKGROUND: Endogenous pancreatic β-cell regeneration is a promising therapeutic approach for enhancing β-cell function and neogenesis in diabetes. Various findings have reported that regeneration might occur via stimulating β-cell proliferation,...
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IL-33 Promotes ST2-Dependent Fibroblast Maturation via P38 and TGF-β in a Mouse Model of Epidural Fibrosis

Wang H, Wu T, Hua F, Sun J, Bai Y, Wang W, Liu J, Zhang M

BACKGROUND: Recent evidence suggests that IL-33, a novel member of the IL-1b family, is involved in organ fibrosis. However, the roles of IL-33 and its receptor ST2 in epidural fibrosis...
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Tissue-Material Integration and Biostimulation Study of Collagen Acellular Matrices

Quintero Sierra LA, Busato A, Zingaretti N, Conti A, Biswas R, Governa M, Vigato E, Parodi PC, Bernardi P, Sbarbati A, Conti G

BACKGROUND: Breast reconstruction after mastectomy using silicone implants is a surgical procedure that occasionally leads to capsular contracture formation. This phenomenon constitutes an important and persistent cause of morbidity, and...
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Clinical Reference Strategy for the Selection of Treatment Materials for Maxillofacial Bone Transplantation: A Systematic Review and Network Meta-Analysis

Zhang S, Zhang X, Li Y, Mao X, Liu R, Qi Y, Lee ES, Jiang HB

Bone graft materials have mixed effects of bone repair in the field of oral maxillofacial surgery. The qualitative analyses performed by previous studies imply that autogenous odontogenic materials and autogenous...
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M2 Macrophage-Derived Concentrated Conditioned Media Significantly Improves Skin Wound Healing

Savitri C, Kwon JW, Drobyshava V, Ha SS, Park K

BACKGROUND: Macrophages, with many different phenotypes play a major role during wound healing process, secreting the cytokines crucial to angiogenesis, cell recruitment and ECM remodeling. Therefore, macrophage-derived cytokines may be...
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Comparison of the Infant and Adult Adipose-Derived Mesenchymal Stem Cells in Proliferation, Senescence, Antioxidative Ability and Differentiation Potential

Wu SH, Yu JH, Liao YT, Liu KH, Chiang ER, Chang MC, Wang Jp

BACKGROUND: Infant adipose-derived mesenchymal stem cells (ADSCs) collected from excised polydactyly fat tissue, which was surgical waste, could be cultured and expanded in vitro in this study. In addition, the...
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