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Correction to: Transplantation of PSA-NCAM-Positive Neural Precursors from Human Embryonic Stem Cells Promotes Functional Recovery in an Animal Model of Spinal Cord Injury

Kim DH, Cho HJ, Park CY, Cho MS, Kim DW

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Correction to: Hsp20 Promotes Endothelial Progenitor Cell Angiogenesis via Activation of PI3K/Akt Signaling Pathway Under Hypoxia

Han Z, He X, Feng Y, Jiang W, Zhou N, Huang X

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The Role of Low-Frequency Electromagnetic Fields on Mesenchymal Stem Cells Differentiation: A Systematic Review

Safavi AS, Sendera A, Haghighipour N, Banas-Zabczyk A

BACKGROUND Low-frequency electromagnetic fields (EMFs) influence biological processes. This present study was aimed at the scientific literature on the use of EMFs in the mesenchymal stem cell differentiation process. MATERIALS AND...
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New Approaches for Enhancement of the Efficacy of Mesenchymal Stem Cell-Derived Exosomes in Cardiovascular Diseases

Ahmed L, Al-Massri K

Cardiovascular diseases (CVDs) remain a major health concern worldwide, where mesenchymal stem cells (MSCs) therapy gives great promise in their management through their regenerative and paracrine actions. In recent years,...
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Bone Regeneration with 3D-Printed Hybrid Bone Scaffolds in a Canine Radial Bone Defect Model

Lee YJ, Ryu YH, Lee SJ, Moon SH, Kim KJ, Jin BJ, Lee KD, Park JK, Lee JW, Lee SJ, Jeong HJ, Rhie JW

BACKGROUND: The repair of large bone defects remains a significant challenge in clinical practice and requires bone grafts or substitute materials. In this study, we developed a unique hybrid bone...
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Development and Application of Three-Dimensional Bioprinting Scaffold in the Repair of Spinal Cord Injury

Lu D, Yang Y, Zhang P, Ma Z, Li W, Song Y, Feng H, Yu W, Ren F, Li T, Zeng H, Wang J

Spinal cord injury (SCI) is a disabling and destructive central nervous system injury that has not yet been successfully treated at this stage. Three-dimensional (3D) bioprinting has become a promising...
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A Biodegradable Polymeric Matrix for the Repair of Annulus Fibrosus Defects in Intervertebral Discs

Saghari Fard MR, Krueger JP, Stich S, Berger P, Kühl AA, Sittinger M, Hartwig T, Endres M

BACKGROUND: Tissue defects in the annulus fibrosus (AF) due to intervertebral disc (IVD) degeneration or after nucleodiscectomy have little self-healing capacity. To prevent progressive degeneration of the IVD, the AF...
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L-Theanine-Treated Adipose-Derived Mesenchymal Stem Cells Alleviate the Cytotoxicity Induced by N-Nitrosodiethylamine in Liver

Lai YJ, Sung YT, Lai YA, Chen LN, Chen TS, Chien CT

BACKGROUND: Liver inflammation is the main cause of severe liver diseases, including liver fibrosis, steatohepatitis, cirrhosis and hepatocellular carcinoma. Cell therapy topics are receiving increasingly more attention. The therapeutic applications...
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Expression of RUNX2/LAPTM5 in the Induction of MC3T3-e1 Mineralization and Its Possible Relationship with Autophagy

Xing L, Li Y, Li W, Liu R, Geng Y, Ma W, Qiao Y, Li J, Lv Y, Fang Y, Xu P

BACKGROUND: The study aims to correlate osteogenesis with autophagy during the mineralization induction of MC3T3-e1 through exploring the expression of runt-related transcription factor 2 (RUNX2)/lysosomal-associated transmembrane protein 5 (LAMPT5). METHODS: The...
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Modeling Human Gonad Development in Organoids

Pryzhkova MV, Boers R, Jordan PW

BACKGROUND: Our learning about human reproductive development is greatly hampered due to the absence of an adequate model. Animal studies cannot truthfully recapitulate human developmental processes, and studies of human...
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From In Vitro to Perioperative Vascular Tissue Engineering: Shortening Production Time by Traceable Textile-Reinforcement

Mohapatra SR, Rama E, Melcher C, Call T, Enezy-Ulbrich MAA, Pich A, Apel C, Kiessling F, Jockenhoevel S

BACKGROUND: The production of tissue-engineered vascular graft (TEVG) usually involves a prolonged bioreactor cultivation period of up to several weeks to achieve maturation of extracellular matrix and sufficient mechanical strength....
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Silica-Capped and Gold-Decorated Silica Nanoparticles for Enhancing Effect of Gold Nanoparticle-Based Photothermal Therapy

Park JH, Choe HS, Kim SW, Im GB, Um SH, Kim JH, Bhang SH

BACKGROUND: Various methods based on gold nanoparticles (AuNPs) have been applied to enhance the photothermal effect. Among these methods, combining gold nanoparticles and stem cells has been suggested as a...
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Transplantation of Differentiated Tonsil-Derived Mesenchymal Stem Cells Ameliorates Murine Duchenne Muscular Dystrophy via Autophagy Activation

Park S, Jeong S, Nam YH, Yum Y, Jung SC

BACKGROUND: Skeletal muscles play many important roles in the human body and any malfunction or disorder of the skeletal muscles can lead to a reduced quality of life. Some skeletal...
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Temporal Modulation of DNA Methylation and Gene Expression in Monolayer and 3D Spheroids of Dental Pulp Stem Cells during Osteogenic Differentiation: A Comparative Study

Raik S, Thakur R, Rattan V, Kumar N, Pal A, Bhattacharyya S

BACKGROUND: Human mesenchymal stem cells are being used for various regenerative applications in past decades. This study chronicled a temporal profile of the transcriptional pattern and promoter methylation status of the...
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The Combination of Platelet Rich Plasma Gel, Human Umbilical Mesenchymal Stem Cells and Nanohydroxyapatite/polyamide 66 Promotes Angiogenesis and Bone Regeneration in Large Bone Defect

Liu W, Huang Y, Liu D, Zeng T, Wang J, Li A, Wang D, Wang X

BACKGROUND: In the present study, a novel tissue engineering bone graft including platelet rich plasma gel (PRP gel), human umbilical mesenchymal stem cells (HUMSCs) and nanohydroxyapatite/polyamide 66 (nHA-PA66) was constructed....
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Hsp20 Promotes Endothelial Progenitor Cell Angiogenesis via Activation of PI3K/Akt Signaling Pathway under Hypoxia

Han Z, He X, Feng Y, Jiang W, Zhou N, Huang X

BACKGROUND: Mandibular distraction osteogenesis (MDO) is a kind of endogenous tissue engineering technology that lengthens the jaw and opens airway so that a patient can breathe safely and comfortably on...
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Human Fetal Cartilage-Derived Progenitor Cells Exhibit AntiInflammatory Effect on IL-1β-Mediated Osteoarthritis Phenotypes In Vitro

Kim J, Tran ANT, Lee JY, Park SH, Park SR, Min BH, Choi BH

BACKGROUND: In this study, we have investigated whether human fetal cartilage progenitor cells (hFCPCs) have antiinflammatory activity and can alleviate osteoarthritis (OA) phenotypes in vitro. METHODS: hFCPCs were stimulated with various...
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A Vitronectin-Derived Peptide Restores Ovariectomy-Induced Bone Loss by Dual Regulation of Bone Remodeling

Kang HK, Park CY, Jung SY, Jo SB, Min BM

BACKGROUND: Bone remodeling is tightly regulated through bone resorption and bone formation; imbalances in bone remodeling can cause various pathological conditions such as osteoporosis. Antiresorptive agents commonly used for treating...
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A Combination of Surgical and Chemical Induction in a Rabbit Model for Osteoarthritis of the Knee

Go EJ, Kim SA, Cho ML, Lee KS, Shetty AA, Kim SJ

BACKGROUND: Appropriate animal models of osteoarthritis (OA) are essential to develop new treatment modalities for OA. A combination of surgical and chemical induction could be appropriate for OA models. METHODS: Rabbit...
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Transplantation of PSA-NCAM-Positive Neural Precursors from Human Embryonic Stem Cells Promotes Functional Recovery in an Animal Model of Spinal Cord Injury

Kim DH, Cho HJ, Park CY, Cho MS, Kim DW

BACKGROUND: Spinal cord injury (SCI) results in permanent impairment of motor and sensory functions at and below the lesion site. There is no therapeutic option to the functional recovery of...
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