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Scaffold Engineering with Flavone-Modified Biomimetic Architecture for Vascular Tissue Engineering Applications

Xie C, Guo T, Wang W, Li G, Cai Z, Chen S, Wang X, Liu Z, Wang Z

BACKGROUND: Vascular intimal hyperplasia (IH) is one of the key challenges in the clinical application of smalldiameter vascular grafts. Current tissue engineering strategies focus on vascularization and antithrombotics, yet few...
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Mesenchymal Stem Cell-Derived Extracellular Vesicles in the Management of COVID19-Associated Lung Injury: A Review on Publications, Clinical Trials and Patent Landscape

Krishnan A, Muthusamy S, Fernandez FB, Kasoju N

The unprecedented COVID-19 pandemic situation forced the scientific community to explore all the possibilities from various fields, and so far we have seen a lot of surprises, eureka moments and...
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Correction: Demineralized Dentin Matrix for Dental and Alveolar Bone Tissues Regeneration: An Innovative Scope Review

Grawish ME, Grawish LM, Grawish HM, Grawish MM, Holiel AA, Sultan N, El-Negoly SA

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Development of a Novel Perfusion Rotating Wall Vessel Bioreactor with Ultrasound Stimulation for Mass-Production of Mineralized Tissue Constructs

Cha JM, Hwang YS, Kang DK, Lee J, Cooper ES, Mantalaris A

BACKGROUND: As stem cells are considered a promising cell source for tissue engineering, many culture strategies have been extensively studied to generate in vitro stem cell-based tissue constructs. However, most...
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Comparison of the Angiogenic Ability between SHED and DPSC in a Mice Model with Critical Limb Ischemic

Yong Z, Kuang G, Fengying S, Shoumei X, Duohong Z, Jiacai H, Xuyan T

BACKGROUND: Regenerative medicine by using stem cells from dental pulp is promising for treating patients with critical limb ischemic (CLI). Here, we investigated the difference in the angiogenetic ability of...
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Re-Cellularised Kidney Scaffold for Chikungunya Virus Propagation: A Novel Approach

Walawalkar S, Almelkar S

BACKGROUND: Re-emerging viral attacks are catastrophic for health and economy. It is crucial to grasp the viral life cycle, replication and mutation policies and attack strategies. It is also absolute...
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Preparation and Biocompatibility Study of Contrast-Enhanced Hernia Mesh Material

Ding X, Zhu J, Liu A, Guo Q, Cao Q, Xu Y, Hua Y, Yang Y, Li P

BACKGROUND: Meshes play a crucial role in hernia repair. However, the displacement of mesh inevitably leads to various associated complications. This process is difficult to be traced by conventional imaging...
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Identification of Stem Cell-Like Cells in the Ovary

Dong MH, Kim YY, Ku SY

Understanding the function of stem cells and cellular microenvironments in in vitro oogenesis, including ovarian folliculogenesis, is crucial for reproductive biology. Because mammalian females cannot generate oocytes after birth, the...
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Mast Cells Tryptase Promotes Intestinal Fibrosis in Natural Decellularized Intestinal Scaffolds

Wan J, Wu T, Liu Y, Yang M, Fichna J, Guo Y, Yin L, Chen C

BACKGROUND: Standard two-dimensional (2D) culture has confirmed the mechanism of mast cells (MCs) in the pathogenesis of inflammatory bowel disease (IBD), but the regulation of signaling responses of MCs may...
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Chitosan Scaffold Containing Periostin Enhances Sternum Bone Healing and Decreases Serum Level of TNF-a and IL-6 after Sternotomy in Rat

Salehiamin M, Toolee H, Azami M, Tafti SHA, Mojaverrostami S, Halimi S, Barakzai S, Sobhani A, Abbasi Y

BACKGROUND: In the aftermath of bone injuries, such as cranium and sternum, bone wax (BW) is used to control bleeding from the bone surfaces during surgery. Made up of artificial...
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Demineralized Dentin Matrix for Dental and Alveolar Bone Tissues Regeneration: An Innovative Scope Review

Grawish ME, Grawish LM, Grawish HM, Grawish MM, Holiel AA, Sultan N, El-Negoly SA

BACKGROUND: Dentin is a permeable tubular composite and complex structure, and in weight, it is composed of 20% organic matrix, 10% water, and 70% hydroxyapatite crystalline matrix. Demineralization of dentin...
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Cyclic Stretching Induces Maturation of Human-Induced Pluripotent Stem Cell-Derived Cardiomyocytes through NuclearMechanotransduction

Song M, Jang Y, Kim SJ, Park Y

BACKGROUND: During cardiogenesis, cardiac cells receive various stimuli, such as biomechanical and chemical cues, from the surrounding microenvironment, and these signals induce the maturation of heart cells. Mechanical force, especially...
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Minimal Cube Explant Provides Optimal Isolation Condition of Mesenchymal Stem Cells from Umbilical Cord

Lee AY, Jang KH, Jo CH

BACKGROUND: Enzymatic digestion and explant method have been widely used for isolating umbilical cord-derived mesenchymal stem cells (UC MSCs), although there is still a strong need for robust protocols for...
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Enhanced Bone Regeneration by Bone Morphogenetic Protein-2 after Pretreatment with Low-Intensity Pulsed Ultrasound in Distraction Osteogenesis

Han JJ, Yang HJ, Hwang SJ

BACKGROUND: Bone morphogenetic protein 2 (BMP-2) and low-intensity pulsed ultrasound (LIPUS) have been used to enhance bone healing in distraction osteogenesis (DO). The aim of this study was to assess...
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Selective Serotonin Reuptake Inhibitor Promotes Bone-Tendon Interface Healing in a Rotator Cuff Tear Rat Model

Yoon JP, Yoon JW, Kim HM, Oh JH

BACKGROUND: Selective serotonin reuptake inhibitor (SSRI) is believed to accelerate wound healing, and thus expected to have a positive effect on rotator cuff repair. We hypothesized that SSRI has a...
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Asymmetric Contribution of Blastomere Lineages of First Division of the Zygote to Entire Human Body Using Post-Zygotic Variants

Kwon SG, Bae GH, Choi JH, Mali NM, Jun MS, Kim DS, Han MH, Park S, Ju YS, Choi SH, Oh JW

BACKGROUND: In humans, after fertilization, the zygote divides into two 2n diploid daughter blastomeres. During this division, DNA is replicated, and the remaining mutually exclusive genetic mutations in the genome...
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Abdominoplasty Panniculus as a Source for Human Acellular Dermis: A Preliminary Report

Louri NA, Dey N, AlHasan RN, Abdulla SH, Elsakka M, Gulreez R, Darwish AH, Kadalmani B, Khalifa KBAA

BACKGROUND: In extensive deep dermal burn injuries, split-thickness skin graft (STSG) has been the most preferred treatment option for resurfacing burn wounds. A thick split-thickness skin graft is ideal for...
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Distinctive Roles of Wnt Signaling in Chondrogenic Differentiation of BMSCs under Coupling of Pressure and Platelet-Rich Fibrin

Cheng B, Feng F, Shi F, Huang J, Zhang S, Quan Y, Tu T, Liu Y, Wang J, Zhao Y, Zhang M

BACKGROUND: Although newly formed constructs of feasible pressure-preadjusted bone marrow mesenchymal stem cells (BMSCs) and platelet-rich fibrin (PRF) showed biomechanical flexibility and superior capacity for cartilage regeneration, it is still...
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