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Correction to: Biomimetic Biphasic Electrospun Scaffold for Anterior Cruciate Ligament Tissue Engineering

Tang Y, Tian J, Li L, Huang L, Shen Q, Guo S, Jiang Y

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Role of Stromal Cell-Derived Factor-1 in Endothelial Progenitor Cell-Mediated Vascular Repair and Regeneration

Li JH, Li Y, Huang D, Yao M

Endothelial progenitor cells (EPCs) are immature endothelial cells that participate in vascular repair and postnatal neovascularization and provide a novel and promising therapy for the treatment of vascular disease. Studies...
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Biomimetic Biphasic Electrospun Scaffold for Anterior Cruciate Ligament Tissue Engineering

Tang Y, Tian J, Li L, Huang L, Shen Q, Guo S, Jiang Y

Background: Replacing damaged anterior cruciate ligaments (ACLs) with tissue-engineered artificial ligaments is challenging because ligament scaffolds must have a multiregional structure that can guide stem cell differentiation. Here, we designed a...
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Nigella Sativa-Coated Hydroxyapatite Scaffolds: Synergetic Cues to Stimulate Myoblasts Differentiation and Offset Infections

Amna T, A. Alghamdi AA, Shang K, Hassan MS

BACKGROUND: At present osteoporosis has come into view as a major health concern. Skeletal diseases typified by weak and fragile bones have imposed threats of fissure. Hydroxyapatite (HAP) is known...
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The Senolytic Drug JQ1 Removes Senescent Cells via Ferroptosis

Go S, Kang M, Kwon SP, Jung M, Jeon OH, Kim BS

BACKGROUND Ferroptosis is an iron-dependent, non-apoptotic programmed cell death. Cellular senescence contributes to aging and various age-related diseases through the expression of a senescence-associated secretory phenotype (SASP). Senescent cells are often...
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Fabrication and Characterization of Graphene Oxide-Coated Plate for Efficient Culture of Stem Cells

Park D, Park J, Lee J, Shim CJ, Kim MS, Lee TY, Lim JO

BACKGROUND: For stem cell applications in regenerative medicine, it is very important to produce high-quality stem cells in large quantities in a short time period. Recently, many studies have shown...
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Acellular Scaffolds as Innovative Biomaterial Platforms for the Management of Diabetic Wounds

Tallapaneni V, Kalaivani C, Pamu D, Mude L, Singh SK, Reddy Karri VVS

Diabetic wound (DW) is one of the leading complications of patients having a long history of uncontrolled diabetes. Moreover, it also imposes an economic burden on people suffering from wounds...
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Surface Creasing-Induced Micropatterned GelMA Using HeatingHydration Fabrication for Effective Vascularization

Kasetsiriku S, Ketpun D, Chuah YJ, Sriphutkiat Y, Wang DA, Zhou Y

  • KMID: 2520635
  • Tissue Eng Regen Med.
  • 2021 Oct;18(5):759-773.
  • doi: Vascularization
BACKGROUND Surface modification is used to modify the biomaterials for the regulation of cell culture using different approaches, such as chemical graft and mechanical treatment. However, those conventional methodologies often...
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Effect of Leukocyte-Platelet Rich Fibrin (L-PRF) on Tissue Regeneration and Proliferation of Human Gingival Fibroblast Cells Cultured Using a Modified Method

Mudalal M, Wang Z, Mustafa S, Liu Y, Wang Y, Yu J, Wang S, Sun X, Zhou Y

Background: An in vitro study on rapid culturing method of human gingival fibroblast cells (HGFCs) was established to investigate the potential use of the leukocyte-platelet rich fibrin (L-PRF) in tissue engineering...
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Multilayered Cell Sheets of Cardiac Reprogrammed Cells for the Evaluation of Drug Cytotoxicity

Kwon SP, Song SY, Yoo J, Kim HY, Lee JR, Kang M, Sohn HS, Go S, Jung M, Hong J, Lim S, Kim C, Moon S, Char K, Kim BS

BACKGROUND: Various cell-culture systems have been used to evaluate drug toxicity in vitro. However, factors that affect cytotoxicity outcomes in drug toxicity evaluation systems remain elusive. In this study, we...
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Mucosal Vaccine Delivery Using Mucoadhesive Polymer Particulate Systems

Cho CS, Hwang SK, Gu MJ, Kim CG, Kim SK, Ju DB, Yun CH, Kim HJ

Vaccination has been recently attracted as one of the most successful medical treatments of the prevalence of many infectious diseases. Mucosal vaccination has been interested in many researchers because mucosal...
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Osteogenic and Angiogenic Potency of VEGF165-Transfected Canine Bone Marrow Mesenchymal Cells Combined with Coral Hydroxyapatite in Vitro

Zhang Q, Zhang J, Chen L, Fan Y, Long J, Liu S

BACKGROUND: To explore the osteogenic and angiogenic potential of human vascular endothelial growth factor 165 (hVEGF165) gene-transfected canine bone marrow mesenchymal stem cells (BMSCs) combined with coral hydroxyapatite (CHA) scaffold. METHODS: We constructed...
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Three-Dimensional Cell Cultures as a Research Platform in Lung Diseases and COVID-19

Silva da Costa FAd, Soares MR, Malagutti-Ferreira MJ, da Silva GR, Reis Lı´vero FAd, Ribeiro-Paes JT

Background: Chronic respiratory diseases (CRD) are a major public health problem worldwide. In the current epidemiological context, CRD have received much interest when considering their correlation with greater susceptibility to SARS-Cov-2...
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Atorvastatin Pretreatment Ameliorates Mesenchymal Stem Cell Migration through miR-146a/CXCR4 Signaling

Li N, Guo XY, Zhou J, Yan XL, Yu FF

BACKGROUND: We previously found that atorvastatin (ATV) enhanced mesenchymal stem cells (MSCs) migration, by a yet unknown mechanism. CXC chemokine receptor 4 (CXCR4) is critical to cell migration and regulated by...
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Implantation of Bone Marrow Mesenchymal Stem Cells into Small Intestinal Submucosa Improves Bile Duct Injury in Rabbits

Li Y, Wang P, Hu Xd, Zeng Jd, Fang C, Gan Y, Peng Fy, Yang Xl, Luo D, Li B, Su S

BACKGROUND: Bile duct injury (BDI), which may occur during cholecystectomy procedures and living-donor liver transplantation, leads to life-altering complications and significantly increased mortality and morbidity. Tissue engineering, as an emerging...
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The Combination of Concentrated Growth Factor and AdiposeDerived Stem Cell Sheet Repairs Skull Defects in Rats

Hu T, Zhang H, Yu W, Yu X, Li Z, He L

BACKGROUND: The goal of this study was to create a biomaterial which combines concentrated growth factor (CGF) with an adipose-derived stem cell (ADSC) sheet to promote the repair of skull...
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TGFβ1-Induced Transglutaminase-2 Triggers Catabolic Response in Osteoarthritic Chondrocytes by Modulating MMP-13

Park JY, Bae HC, Pyo SH, Lee MC, Han HS

Background: Transforming growth factor beta 1 (TGFβ1) plays an essential role in maintaining cartilage homeostasis. TGFβ1 is known to upregulate anabolic processes in articular cartilage, but the role of TGFβ1 in...
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Effectiveness and Biocompatibility of Decellularized Nerve Graft Using an In Vivo Rat Sciatic Nerve Model

Kim DH, Shin SH, Lee MK, Lee JJ, Kim JK, Chung YG

BACKGROUND: Decellularized nerve allografting is one of promising treatment options for nerve defect. As an effort to develop more efficient nerve graft, recently we have developed a new decellularization method...
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Therapeutic Effect of IL1β Priming Tonsil Derived-Mesenchymal Stem Cells in Osteoporosis

Yoo M, Cho S, Shin S, Kim JM, Park HG, Cho S, Hwang YK, Park DH

Background: Stem cell therapies can be a new therapeutic strategy that may rebalance anabolic and anti-resorptive effects in osteoporosis patients. Tonsil-derived mesenchymal stem cells (TMSCs) can be an alternative therapeutic source...
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