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Not Stromal Vascular Fraction (SVF) or Nanofat, but Total Stromal-Cells (TOST): A New Definition. Systemic Review of Mechanical Stromal-Cell Extraction Techniques

Copcu HE, Oztan S

The most important and greatest source in the body for regenerative cells is fat tissue. Obtaining regenerative cells from adipose tissue can be done in two ways: Enzymatic and mechanical....
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Electrospun Microvasculature for Rapid Vascular Network Restoration

Han JH, Ko UH, Kim HJ, Kim S, Jeon JS, Shin JH

BACKGROUND: Sufficient blood supply through neo-vasculature is a major challenge in cell therapy and tissue engineering in order to support the growth, function, and viability of implanted cells. However, depending...
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Regenerating the Pulp–Dentine Complex Using Autologous Platelet Concentrates: A Critical Appraisal of the Current Histological Evidence

Riaz A, Shah FA

BACKGROUND: Autologous platelet concentrates such as platelet-rich plasma (PRP) and platelet-rich fibrin (PRF) have gained overwhelming popularity in regenerative endodontics. Clinical evidence reveals the lack of a particular advantage of...
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Investigation of the Clinical Potential of Polarization-Sensitive Optical Coherence Tomography in a Laryngeal Tumor Model

Xin Z, Kim SW, Oak C, Kwon DY, Choi JH, Ko TY, Kim JH, Tang S, Ahn YC

BACKGROUND: The vocal cord tissue consists of three anatomical layers from the surface to deep inside: the epithelium that contains almost no collagen, the lamina propria that is composed of...
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Refunctionalization of Decellularized Organ Scaffold of Pancreas by Recellularization: Whole Organ Regeneration into Functional Pancreas

Chandrika KU, Tripathi R, Kameshwari Y, Rangaraj N, Kumar JM, Singh S

BACKGROUND: Tissue engineering centers on creating a niche similar to the natural one, with a purpose of developing an organ construct. A natural scaffold can replace none while creating a...
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Novel Marine Organism-Derived Extracellular Vesicles for Control of Anti-Inflammation

Jo SH, Kim C, Park SH

BACKGROUND: Extracellular vesicles (EVs) exhibit potential as functional biomolecules for tissue regeneration and immunomodulation as they play important roles in the physiological communication between cells. EV internal cargo contains miRNAs,...
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Advances in the Development of Anti-Adhesive Biomaterials for Tendon Repair Treatment

Zhou H, Lu H

BACKGROUND: Peritendinous adhesion that simultaneous with tendon healing link the healing tendon to the surrounding tissue. It results in functional disability, and has a significant adverse impact on health as...
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Application of Polarization Sensitive-Optical Coherence Tomography to the Assessment of Phase Retardation in Subpleural Cancer in Rabbits

Park JE, Xin Z, Kwon DY, Kim SW, Lee H, Jung MJ, Tang S, Ko TY, Choi JH, Kim JH, Ahn YC, Oak C

BACKGROUND: Polarization sensitive-optical coherence tomography (PS-OCT) provides the unique advantage of being able to measure the optical characteristics of tissues by using polarized light. Although the well-organized fibers of healthy...
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Mechanical Stimulation and Diameter of Fiber Scaffolds Affect the Differentiation of Rabbit Annulus Fibrous Stem Cells

Zhou P, Wei B, Guan J, Chen Y, Zhu Y, Ye Y, Meng Y, Guan J, Mao Y

BACKGROUND: Degeneration of the annulus fibrosus (AF), an important structure of the intervertebral disc, is one of the main causes of degenerative disc disease. Fabrication of scaffolds replicating the stratified...
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Influences of Xeno-Free Media on Mesenchymal Stem Cell Expansion for Clinical Application

Bui HTH, Nguyen LT, Than UTT

Abstract Mesenchymal stem/stromal cells (MSCs) are multipotent somatic stem/progenitor cells that can be isolated from various tissues and have attracted increasing attention from the scientific community. This is due to...
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Intra-articular Injection of Chitosan-Based Supramolecular Hydrogel for Osteoarthritis Treatment

Mou D, Yu Q, Zhang J, Zhou J, Li X, Zhuang W, Yang X

BACKGROUND: Pain and cartilage destruction caused by osteoarthritis (OA) is a major challenge in clinical treatment. Traditional intra-articular injection of hyaluronic acid (HA) can relieve the disease, but limited by the...
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Corneal Repair with Adhesive Cell Sheets of Fetal Cartilage-Derived Stem Cells

Park IS, Kim BK, Truong MD, Yang HS, Park SH, Park HS, Choi BH, Won BH, Min BH

BACKGROUND: Corneal scarring or disease may lead to severe corneal opacification and consequently, severe loss of vision due to the complete loss of corneal epithelial cells. We studied the use...
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Human Dental Pulp Stem Cells (DPSCs) Therapy in Rescuing Photoreceptors and Establishing a Sodium Iodate-Induced Retinal Degeneration Rat Model

Lam C, Alsaeedi HA, Koh AEH, Harun MHN, Hwei ANM, Mok PL, Luu CD, Yong TK, Subbiah SK, Bastion MLC

BACKGROUND: Different methods have been used to inject stem cells into the eye for research. We previously explored the intravitreal route. Here, we investigate the efficacy of intravenous and subretinal-transplanted...
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Comparative Analysis of the Expression of Chondroitin Sulfate Subtypes and Their Inhibitory Effect on Axonal Growth in the Embryonic, Adult, and Injured Rat Brains

Kim MH, Park SR, Choi BH

BACKGROUND: Chondroitin sulfate glycosaminoglycans (CS-GAGs) are the primary inhibitory GAGs for neuronal growth after central nervous system (CNS) injury. However, the inhibitory or permissive activity of CS-GAG subtypes is controversial...
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Histological and Physiological Studies of the Effect of Bone Marrow-Derived Mesenchymal Stem Cells on Bleomycin Induced Lung Fibrosis in Adult Albino Rats

Zakaria DM, Zahran NM, Arafa SAA, Mehanna RA, Abdel-Moneim RA

BACKGROUND: Lung fibrosis is considered as an end stage for many lung diseases including lung inflammatory disease, autoimmune diseases and malignancy. There are limited therapeutic options with bad prognostic outcome....
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Nitric Oxide Produced by the Antioxidant Activity of Verapamil Improves the Acute Wound Healing Process

Han YN, Lee YJ, Kim KJ, Lee SJ, Choi JY, Moon SH, Rhie JW

BACKGROUND: Verapamil is used in the treatment of hypertension, angina pectoris, cardiac arrhythmia, hypertrophic scars, and keloids to block transmembrane calcium ion flux. Verapamil has antioxidant activity, which enhances the...
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Bone Generation Following Repeated Administration of Recombinant Bone Morphogenetic Protein 2

Son HJ, Lee MN, Kim Y, Choi H, Jeong BC, Oh SH, Kim JW, Kwon SH, Kim SH, Song SC, Lee SE, Koh JT

BACKGROUND: The delivery of recombinant human bone morphogenetic protein 2 (rhBMP2) by using various carriers has been used to successfully induce bone formation in many animal models. However, the effect...
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