- Thrombospondin-1 and Inhibition of Tumor Growth
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Jeong GB
- KMID: 2150435
- Korean J Phys Anthropol.
- 2015 Dec;28(4):175-184.
- doi: 10.11637/kjpa.2015.28.4.175
Thrmobospondin-1 is the multifunctional protein that modulates endothelial cell and tumor cell behavior via several cell surface receptors and inhibits angiogenesis. In vitro, thrombospondin-1 alters adhesion, proliferation, motility, and survival... -
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- mRNA Expression of Thrombospondin-1 and -2 in Severe Endometriosis Patients in Korean Women
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Hur SE, Lee JY, Moon HS, Chung HW
- KMID: 1864688
- Korean J Fertil Steril.
- 2005 Sep;32(3):253-260.
OBJECTIVE: We investigated the expression of TSP-1 and -2 in eutopic endometrium of advanced endometriosis and control patients. METHODS: The 33 endometriosis patients and 32 controls were enrolled. Endometrial samples were... -
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- Sphingosylphosphorylcholine Induces Thrombospondin-1 Secretion in MCF10A Cells via ERK2
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Kang JH, Kim HJ, Park MK, Lee CH
- KMID: 2395812
- Biomol Ther.
- 2017 Nov;25(6):625-633.
- doi: 10.4062/biomolther.2016.228
Sphingosylphosphorylcholine (SPC) is one of the bioactive phospholipids that has many cellular functions such as cell migration, adhesion, proliferation, angiogenesis, and Ca²⺠signaling. Recent studies have reported that SPC induces... -
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- Inhibition of Angiogenesis by the First Type I Repeat Peptides of Thrombospondin-1
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Yoo BI, Jeong GB
- KMID: 2150440
- Korean J Phys Anthropol.
- 2015 Dec;28(4):223-238.
- doi: 10.11637/kjpa.2015.28.4.223
Angiogenesis is the fundamental biological phenomenon in the development of vertebrates and various pathophysiological process such as cancer, inflammation and wound healing. Thrombospondin-1 is a well-known anti-angiogenic molecule which is... -
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- Responsive site on the thrombospondin-1 promotor to down-regulation by phorbol 12-myristate 13-acetate in porcine aortic endothelial cells
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Kim SA, Hong KJ
- KMID: 755077
- Exp Mol Med.
- 2000 Sep;32(3):135-140.
Thrombospondin-1 (TSP-1), a multifunctional extracellular matrix protein, inhibits neovascularization and is implicated in the regression of tumor growth and metastasis. We found that the synthesis of TSP-1 in... -
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- Higher Plasma Thrombospondin-1 Levels in Patients With Coronary Artery Disease and Diabetes Mellitus
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Choi KY, Kim DB, Kim MJ, Kwon BJ, Chang SY, Jang SW, Cho EJ, Rho TH, Kim JH
- KMID: 1826381
- Korean Circ J.
- 2012 Feb;42(2):100-106.
- doi: 10.4070/kcj.2012.42.2.100
BACKGROUND AND OBJECTIVES: Thrombospondin-1 (TSP-1) is associated with atherosclerosis in animals with diabetes mellitus (DM). But, no study has investigated the role of TSP-1 in human atherosclerosis. This study investigated... -
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- Thrombospondin-1 and -2 Expressions in Hepatocellular Carcinomas: an Association with Tumor Angiogenesis and p53 Overexpression
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Chung JS, Park HS, Son HJ, Kang MJ, Moon WS
- KMID: 1855942
- Korean J Pathol.
- 2005 Aug;39(4):215-221.
Background : It has been suggested that thrombospondin (TSP) is a p53-dependent negative regulator of tumor angiogenesis. TSP expression and localization in hepatocellular carcinomas (HCCs) and its association with overexpression... -
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- The Effect of Endocrine Therapy on Angiogenesis and the Expression of Thrombospondin-1 and Vascular Endothelial Growth Factor in Prostate Cancer
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Kwak C, Jeong H, Byun SS, Baek M, Kim C, Kim T, Lee SE
- KMID: 2292617
- Korean J Urol.
- 2002 May;43(5):372-379.
PURPOSE: The exact role of angiogenesis in prostate cancer is unknown. We investigated whether endocrine therapy inhibits angiogenesis, and influences the expression of thrombospondin-1 (TSP-1), a potent inhibitor of angiogenesis,... -
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- Inhibition of trichostatin A-induced antiangiogenesis by small-interfering RNA for thrombospondin-1
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Kang JH, Kim SA, Chang SY, Hong S, Hong KJ
- KMID: 1047092
- Exp Mol Med.
- 2007 Jun;39(3):402-411.
Expression of thrombospondin-1 (TSP-1), which is a known inhibitor of tumor growth and angiogenesis, is reciprocally regulated by positive regulators, such as VEGF. Additionally, trichostatin A (TSA) suppresses tumor progression... -
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- Expression of Vascular Endothelial Growth Factor and Thrombospondin-1 mRNA Related to Microvessel Density in Invasive Cervical Carcinomas
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Lee JE, Lee SK, Chi SG
- KMID: 2272998
- Korean J Obstet Gynecol.
- 2006 Dec;49(12):2573-2582.
OBJECTIVE: Vascular Endothelial Growth Factor (VEGF) is a potent stimulator of angiogenesis in solid tumors. Thrombospondin-1 (TSP-1) has inhibitory role in cancer cell proliferation and metastasis. To analyze the correlation... -
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- Expressions of Thrombospondin-1 and Vascular Endothelial Growth Factor and Their Relationship with p53 Status in Prostate Cancer and Benign Prostatic Hyperplasia
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Kim C, Baek MK, Kim TH, Jeong H, Byun SS, Jeon YK, Kwak C, Kang GH, Lee SE
- KMID: 2292640
- Korean J Urol.
- 2002 Jul;43(7):591-597.
PURPOSE: The precise role of angiogenesis in prostate cancer should be defined. Several reports suggest that thrombospondin-1 (TSP-1) possesses a tumor suppressor function, possibly through its ability to inhibit tumor... -
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- Aberrant CpG Islands Hypermethylation Profiles in Malignant Gliomas
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Kim KR, Kim E, Son EI
- KMID: 1734665
- Brain Tumor Res Treat.
- 2014 Apr;2(1):29-35.
- doi: 10.14791/btrt.2014.2.1.29
BACKGROUND: The authors analyzed whether the promoter hypermethylation of cancer-related genes was involved in the tumorigenesis of malignant gliomas. METHODS: A total of 29 patients received surgery and histologically confirmed to... -
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- The Expression of Vascular Endothelial Growth Factor and Thrombospondin-1 in Wilms' Tumor
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Jeong SJ, Park EC, Kwak C, Jin RJ, Lee SE, Choi H
- KMID: 2292344
- Korean J Urol.
- 2001 Mar;42(3):265-272.
PURPOSE: With the process of neoangiogenesis being linked to the growth and metastasis of various tumors, anticancer therapeutics with a basis in the suppression of neoangiogenesis has recently... -
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- Caffeine-induced endothelial cell death and the inhibition of angiogenesis
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Li H, Jin SY, Son HJ, Seo JH, Jeong GB
- KMID: 2046758
- Anat Cell Biol.
- 2013 Mar;46(1):57-67.
- doi: 10.5115/acb.2013.46.1.57
Numerous studies have shown that adenosine or adenosine agonists can stimulate angiogenesis. However, the effect of caffeine (a known adenosine receptor antagonist) on angiogenesis has not been previously studied. Accordingly,... -
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- Association of serum levels of vascular endothelial growth factor and thrombospondin-1 to body mass index in polycystic ovary syndrome: a case-control study
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Tahergorabi Z, Salmani F, Jonaidabad SH, Behdani B, Yazdi P, Zardast M, Moodi M
- KMID: 2462120
- Obstet Gynecol Sci.
- 2019 Nov;62(6):420-428.
- doi: 10.5468/ogs.2019.62.6.420
PURPOSE: Polycystic ovary syndrome (PCOS) is a gynecological endocrine disorder that is characterized by disturbances in ovarian blood flow and angiogenesis. The aim of this study was to determine the... -
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- Comparative profiling of plasma proteome from breast cancer patients reveals thrombospondin-1 and BRWD3 as serological biomarkers
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Suh EJ, Kabir MH, Kang UB, Lee JW, Yu J, Noh DY, Lee C
- KMID: 1120140
- Exp Mol Med.
- 2012 Jan;44(1):36-44.
- doi: 10.3858/emm.2012.44.1.003
Breast cancer is the most common cancer in women worldwide. It is necessary to identify biomarkers for early detection, to make accurate prognoses, and to monitor for any recurrence of... -
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- The Effect of Epicatechin on the High Glucose-induced TSP-1 Expression and MMP-2 Activity in Rat Vascular Smooth Muscle Cells
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Ryu GR, Kang JH, Hong KJ, Jeong IK, Jang HI, Rhie DJ, Yoon SH, Hahn SJ, Kim MS, Jo YH, Kim MJ
- KMID: 2200845
- J Korean Soc Endocrinol.
- 2006 Aug;21(4):302-310.
- doi: 10.3803/jkes.2006.21.4.302
BACKGROUND: The incidence of atherosclerosis is well correlated with the progression of type 2 diabetes mellitus. High plasma glucose in uncontrolled diabetic patients evokes many vascular complications such as atherosclerosis.... -
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- Changes of Gene Expression in NIH3T3 Cells Exposed to Osmotic and Oxidative Stresses
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Lee JS, Jung JH, Kim TH, Seo JS
- KMID: 2166167
- Genomics Inform.
- 2004 Jun;2(2):67-74.
Cells consistently face stressful conditions, which cause them to modulate a variety of intracellular processes and adapt to these environmental changes via regulation of gene expression. Hyperosmotic and oxidative stresses... -
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- Cell-type specific regulation of thrombospondin-1 expression and its promoter activity by regulatory agents
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Kim SA, Kang JH, Cho IH, Bae SW, Hong KJ
- KMID: 938874
- Exp Mol Med.
- 2001 Sep;33(3):117-123.
Thrombospondin-1 (TSP-1), a multifunctional protein that is able to function as a negative regulator of solid tumor progression and angiogenesis, is normally present at a very low level but rapidly... -
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- Weakening of the repressive YY-1 site on the thrombospondin-1 promoter via c-Jun/YY-1 interaction
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Kang JH, Chang SY, Yeom DH, Kim SA, Um SH, Hong KJ
- KMID: 1094074
- Exp Mol Med.
- 2004 Aug;36(4):300-310.
Thrombospondin-1 (TSP-1) level is tightly regulated at the transcriptional level. To determine the detailed molecular mechanisms of TSP-1 expression, nine serial 5'-deletion constructs of the human genomic tsp-1 promoter (nucleotides... -
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