- Regulation of Th2 Cell Immunity by Dendritic Cells
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Na H, Cho M, Chung Y
- KMID: 2154806
- Immune Netw.
- 2016 Feb;16(1):1-12.
- doi: 10.4110/in.2016.16.1.1
Th2 cell immunity is required for host defense against helminths, but it is detrimental in allergic diseases in humans. Unlike Th1 cell and Th17 cell subsets, the mechanism by which... -
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- The Role of Th2 Cell in Allergic Reaction
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Oh JW
- KMID: 2314222
- Pediatr Allergy Respir Dis.
- 2000 Sep;10(3):199-206.
No abstract available. -
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- BCG Immunomodulation Therapy in Asthma
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Choi IS
- KMID: 2274931
- Chonnam Med J.
- 2003 Jun;39(2):61-65.
Asthma is well known to be a Th2-associated disease. Since Th1 and Th2 cells are reciprocally regulated, several studies using animal asthma models have shown to reverse the Th2 response... -
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- IL-18Ralpha Mediated GATA-3 Induction by Th2 Cells: IL-12 Supports IL-18Ralpha Expression in Th2 Cells
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Joo IS, Sun MJ, Kim DY, Lee SJ, Ha YM, Cho JJ, Park CS, Ahn HJ
- KMID: 2150585
- Immune Netw.
- 2005 Mar;5(1):16-22.
- doi: 10.4110/in.2005.5.1.16
BACKGROUND: IL-18 was originally cloned as a IFN-gamma inducing factor in primed T cells. In synergy with IL-12, IL-18 has been shown to induce strikingly high levels of IFN-gamma production... -
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- Prostaglandin D2 and TH2 Inflammation in the Pathogenesis of Bronchial Asthma
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Arima M, Fukuda T
- KMID: 1036144
- Korean J Intern Med.
- 2011 Mar;26(1):8-18.
- doi: 10.3904/kjim.2011.26.1.8
Prostaglandin D2 (PGD2) is a major prostanoid, produced mainly by mast cells, in allergic diseases, including bronchial asthma. PGD2-induced vasodilatation and increased permeability are well-known classical effects that may be... -
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- Peripheral Th1 and Th2 Lymphocytes Values by Intracellular Cytokine Staining for Interferon-and Interleukin-4 in the Patients with Repeated Spontaneous Abortion
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Park AJ, Lee MK
- KMID: 2038246
- Korean J Lab Med.
- 2005 Apr;25(2):111-115.
BACKGROUND: In the women who experienced recurrent spontaneous abortions (RSA), cellular immune abnormalities of peripheral blood Natural Killer (NK) cell have been reported and the imbalance of Th1 and Th2... -
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- Regulation and Function of Th17 Cells
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- KMID: 2090204
- Korean J Asthma Allergy Clin Immunol.
- 2011 Mar;31(1):1-8.
Naive CD4+ helper T (Th) cells, upon activation by antigen-presenting cells (APC), differentiate into different types of effecter cells that are characterized by their distinct cytokine production profiles and immune... -
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- Stem cell therapy in animal models of allergic airway diseases
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Cho KS
- KMID: 2165077
- Allergy Asthma Respir Dis.
- 2016 May;4(3):167-173.
- doi: 10.4168/aard.2016.4.3.167
Allergic airway diseases are characterized by T-helper type 2 (Th2)-skewed eosinophilic inflammation, mucus hypersecretion, and airway hyperresponsiveness. The excessive activation of Th2 cells due to insufficient suppression of regulatory T... -
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- Overexpression of CIITA in T Cells Aggravates Th2-Mediated Colitis in Mice
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Kim TW, Park HJ, Choi EY, Jung KC
- KMID: 1781909
- J Korean Med Sci.
- 2006 Oct;21(5):877-882.
- doi: 10.3346/jkms.2006.21.5.877
The MHC class II transactivator (CIITA) is the master transcriptional regulator of genes involved in MHC class II restricted antigen presentation. Previously we suggested another role of CIITA in Th1/Th2... -
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- CD4+ T Helper Cells Engineered to Produce IL-10 Reverse Allergen-induced Airway Hyperreactivity and Inflammation
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Oh JW, Dekruyff R, Umetsu D
- KMID: 1570680
- Pediatr Allergy Respir Dis.
- 2000 Dec;10(4):279-289.
PURPOSE: Asthma is characterized by airway hyperreactivity to a variety of specific and nonspecific stimuli, by chronic airway inflammation with pulmonary eosinophilia, by mucus hypersecretion, and by increased serum IgE... -
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- Mechanism of Allergic Asthma Pathogenesis by Protease Allergen
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Lee SH
- KMID: 2168219
- Hanyang Med Rev.
- 2013 Feb;33(1):39-44.
- doi: 10.7599/hmr.2013.33.1.39
Asthma is a complex immune mediated chronic inflammatory lung disease characterized by chronic inflammation of the airways, airway hyper-responsiveness and airway obstruction, and the prevalence of this disease has increased... -
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- T-Helper Type 2 Cells Direct Antigen-Induced Eosinophilic Skin Inflammation in Mice
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Kaminuma O, Nishimura , Kitamura N, Saeki M, Hiroi T, Mori A
- KMID: 2428852
- Allergy Asthma Immunol Res.
- 2018 Jan;10(1):77-82.
- doi: 10.4168/aair.2018.10.1.77
Eosinophilic inflammation in combination with immunoglobulin E (IgE) production is a characteristic feature of atopic dermatitis. Although activated T-helper type (Th) 2 cells play critical roles in the local accumulation... -
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- Expression of TARC in Nasal Epithelial Cells by IL-4/IL-13 and TNF-alpha in Allergic Rhinitis
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Lee KH, Kim SW, Shin SY, Cho JS
- KMID: 2131937
- J Rhinol.
- 2008 Nov;15(2):129-133.
BACKGROUND: Thymus and Activation-Regulated Chemokine (TARC) is a highly specific ligand for CCR4 expressed in Th2 lymphocytes. Local production of TARC may play an important role in the induction and... -
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- Expression of Th1 and Th2 type cytokines responding to HBsAg and HBxAg in chronic hepatitis B patients
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Lee M, Lee MA, Lee SK, Son M, Cho SW, Park S, Kim HI
- KMID: 648077
- J Korean Med Sci.
- 1999 Apr;14(2):175-181.
- doi: 10.3346/jkms.1999.14.2.175
The cytokine pattern on viral antigen recognition is believed to exert a profound influence on the resolution of viral infections and viral clearance. This study was initiated to investigate whether... -
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- Genetic controls of Th17 cell differentiation and plasticity
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Dong C
- KMID: 991617
- Exp Mol Med.
- 2011 Jan;43(1):1-6.
- doi: 10.3858/emm.2011.43.1.007
CD4+ T lymphocytes play a major role in regulation of adaptive immunity. Upon activation, naive T cells differentiate into different functional subsets. In addition to the classical Th1 and Th2... -
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- Role of IL-23 and Th17 Cells in Airway Inflammation in Asthma
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Nakajima H, Hirose K
- KMID: 1456191
- Immune Netw.
- 2010 Feb;10(1):1-4.
- doi: 10.4110/in.2010.10.1.1
Asthma is characterized by chronic airway inflammation with intense eosinophil and lymphocyte infiltration, mucus hyperproduction, and airway hyperresponsiveness. Accumulating evidence indicates that antigen-specific Th2 cells and their cytokines such as... -
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- Effect of interleukin-12 on airway inflammation in mouse model of bronchial asthma
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Lee SY, Song JS
- KMID: 2286080
- J Asthma Allergy Clin Immunol.
- 1999 Feb;19(1):79-90.
BACKGROUND: Th2-like cells are thought to play a crucial role in the recruitment and activation of eosinophil in bronchial asthma. In contrast to Th2 cytokine, Thl cytokine IFN-y decreases eosinophil recruitment. Previous... -
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- Mast cells play a key role in Th2 cytokine-dependent asthma model through production of adhesion molecules by liberation of TNF-alpha
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Chai OH, Han EH, Lee HK, Song CH
- KMID: 991621
- Exp Mol Med.
- 2011 Jan;43(1):35-43.
- doi: 10.3858/emm.2011.43.1.004
Mast cells are well recognized as key cells in allergic reactions, such as asthma and allergic airway diseases. However, the effects of mast cells and TNF-alpha on T-helper type 2... -
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- The Role of Thymic Stromal Lymphopoietin (TSLP) in Glomerulonephritis
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Lee KH, Yang JW, Cho JY, Lee JY, Lim EK, Eisenhut M, Jeong DY, Steingroever J, Shin JI
- KMID: 2435350
- Child Kidney Dis.
- 2018 Apr;22(1):17-21.
- doi: 10.3339/jkspn.2018.22.1.17
Thymic stromal lymphopoietin (TSLP) is an interleukin-7-like cytokine that is an important trigger and initiator of many allergic diseases. TSLP promotes a T-helper type 2 (Th2) cytokine response that can... -
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- The Role of Type 2 Innate Lymphoid Cells in Allergic Diseases
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- KMID: 2299449
- Korean J Asthma Allergy Clin Immunol.
- 2012 Dec;32(4):207-212.
Innate lymphoid cells have recently been identified to be a cell population that has morphology typical of lymphocytes but lacks rearranged antigen receptors. It can be classified into RORgammat innate... -
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