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Factors and Mechanisms Involved in the Coupling from Bone Resorption to Formation: How Osteoclasts Talk to Osteoblasts

Ikeda K, Takeshita

Bone remodeling is the fundamental means by which the quality as well as quantity of the skeleton is maintained throughout adult life. When bone remodeling goes awry, a metabolic bone...
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Endoscopic Closure for Full-Thickness Gastrointestinal Defects: Available Applications and Emerging Innovations

Takeshita , Ho KY

Full-thickness gastrointestinal defects such as perforation, anastomotic leak, and fistula are severe conditions caused by various types of pathologies. They are more likely to require intensive care and a long...
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Raman Spectroscopy for the Endoscopic Diagnosis of Esophageal, Gastric, and Colonic Diseases

Sharma N, Takeshita , Ho KY

Globally white-light endoscopy with biopsy sampling is the gold standard diagnostic modality for esophageal, gastric, and colonic pathologies. However, there is overwhelming evidence to highlight the deficiencies of an approach...
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Fecal microbiota transplantation for recurrent Clostridium difficile infection in a patient with ulcerative colitis

Nanki K, Mizuno S, Matsuoka K, Ono K, Sugimoto S, Kiyohara H, Arai M, Nakashima , Takeshita , Saigusa K, Senoh M, Fukuda T, Naganuma M, Kato H, Suda W, Hattori M, Kanai T

Fecal microbiota transplantation (FMT) has been reported as a safe and effective therapy in patients with refractory and recurrent Clostridium difficile infection (CDI). FMT has also been reported as a...
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Incidence of metastasis in circumflex iliac nodes distal to the external iliac nodes in cervical cancer

Takeshita , Todo Y, Okamoto K, Sudo S, Yamashiro , Kato H

OBJECTIVE: A causal relationship between removal of circumflex iliac nodes distal to the external iliac nodes (CINDEIN) and lower leg edema has been recently suggested. The aim of this study...
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Implications of para-aortic lymph node metastasis in patients with endometrial cancer without pelvic lymph node metastasis

Todo Y, Takeshita , Okamoto K, Yamashiro , Kato H

OBJECTIVE: The aim of this study was to confirm the incidence and implications of a lymphatic spread pattern involving para-aortic lymph node (PAN) metastasis in the absence of pelvic lymph...
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A prediction model of survival for patients with bone metastasis from uterine cervical cancer

Matsumiya , Todo Y, Okamoto K, Takeshita , Yamazaki H, Yamashiro , Kato H

OBJECTIVE: The aim of the study was to establish a predictive model of survival period after bone metastasis from cervical cancer. METHODS: A total of 54 patients with bone metastasis from...
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Fourth molar: A retrospective study and literature review of a rare clinical entity

Bamgbose B, Okada S, Hisatomi M, Yanagi Y, Takeshita , Abdu ZS, Ekuase EJ, Asaumi JI

PURPOSE: The prevalence of supernumerary teeth has been reported to be between 0.1% and 3.8%. The aim of this study was to determine the prevalence, clinical significance, and associated pathologies...
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Transient forebrain ischemia induces impairment in cognitive performance prior to extensive neuronal cell death in Mongolian gerbil (Meriones unguiculatus)

Kondo T, Yoshida S, Nagai H, Takeshita , Mino M, Morioka H, Nakajima T, Kusakabe K, Okada T

In Mongolian gerbils, bilateral common carotid artery occlusion (BCCAO) for several minutes induces ischemia, due to an incomplete circle of Willis, resulting in delayed neuronal cell death in the Cornet...
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Therapeutic significance of full lymphadenectomy in early-stage ovarian clear cell carcinoma

Yamazaki H, Todo Y, Shimada C, Takeshita , Minobe S, Okamoto K, Yamashiro , Kato H

OBJECTIVES: This study evaluated the therapeutic significance of full lymphadenectomy in early-stage ovarian clear cell carcinoma (OCCC). METHODS: We retrospectively reviewed records of 127 consecutive patients with pT1/pT2 and M0 OCCC...
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Single fecal microbiota transplantation failed to change intestinal microbiota and had limited effectiveness against ulcerative colitis in Japanese patients

Mizuno S, Nanki K, Matsuoka K, Saigusa K, Ono K, Arai M, Sugimoto S, Kiyohara H, Nakashima , Takeshita , Naganuma M, Suda W, Hattori M, Kanai T

BACKGROUND/AIMS: Recent developments in analytical techniques including next-generation sequencing have clarified the correlation between intestinal microbiota and inflammatory bowel disease. Fecal microbiota transplantation (FMT) for patients with ulcerative colitis (UC)...
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