- The Effects of Recombinant Synucleins and Insulin-like Growth Factor 1 on Cancer Cell Migration
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Shin W, Kim J
- KMID: 1717684
- J Bacteriol Virol.
- 2012 Jun;42(2):133-151.
- doi: 10.4167/jbv.2012.42.2.133
The synuclein family consists of three distinct genes, alpha-synuclein, beta-synuclein, and gamma-synuclein. The alpha-synuclein and beta-synuclein are predominately expressed in brain and especially alpha-synuclein is related with Parkinson's disease, Alzheimer's... -
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- Alpha-Synuclein in Skin Nerve Fibers as a Biomarker for Alpha-Synucleinopathies
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Kim JY, Illigens B, McCormick , Wang N, Gibbons CH
- KMID: 2467725
- J Clin Neurol.
- 2019 Apr;15(2):135-142.
- doi: 10.3988/jcn.2019.15.2.135
The common pathological features of synucleinopathies are abnormal aggregates of the synaptic protein alpha-synuclein (αSN) in the cytoplasm of neurons or glia. These abnormal aggregates appear several years before the... -
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- The gamma-Synuclein Expression in Breast Cancer and its Correlation with the Expression of the HER-2/neu Gene
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Kim SR, Choi WH, Park JH, Nam ES, Cho SJ, Park CH
- KMID: 1745051
- J Breast Cancer.
- 2007 Jun;10(2):114-119.
- doi: 10.4048/jbc.2007.10.2.114
PURPOSE: Synuclein has been identified as an important neuroprotein for developing pathologic deposits in Alzheimer's and Parkinson's disease patients. gamma-synuclein is also known as a breast cancer-specific gene 1 thats's... -
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- Effect of rs3910105 in the Synuclein Gene on Dopamine Transporter Availability in Healthy Subjects
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Seo Y, Pak K, Nam HY, Seok JW, Lee MJ, Kim EJ, Lee JM, Kim SJ, Kim IJ
- KMID: 2415538
- Yonsei Med J.
- 2018 Aug;59(6):787-792.
- doi: 10.3349/ymj.2018.59.6.787
PURPOSE: The present study investigated associations between dopamine transporter (DAT) availability and α-synuclein levels in cerebrospinal fluid, as well as synuclein gene (SNCA) transcripts, and the effect of single nucleotide... -
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- siRNA-Mediated Suppression of Synuclein gamma Inhibits MDA-MB-231 Cell Migration and Proliferation by Downregulating the Phosphorylation of AKT and ERK
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He J, Xie N, Yang J, Guan H, Chen W, Wu H, Yuan Z, Wang K, Li G, Sun J, Yu L
- KMID: 2286346
- J Breast Cancer.
- 2014 Sep;17(3):200-206.
- doi: 10.4048/jbc.2014.17.3.200
PURPOSE: Synuclein-gamma (SNCG), which was initially identified as breast cancer specific gene 1, is highly expressed in advanced breast cancers, but not in normal or benign breast tissue. This study... -
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- MPTP-induced vulnerability of dopamine neurons in A53T α-synuclein overexpressed mice with the potential involvement of DJ-1 downregulation
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Lee S, Oh ST, Jeong HJ, Pak SC, Park HJ, Kim J, Cho HS, Jeon S
- KMID: 2395257
- Korean J Physiol Pharmacol.
- 2017 Nov;21(6):625-632.
- doi: 10.4196/kjpp.2017.21.6.625
Familial Parkinson's disease (PD) has been linked to point mutations and duplication of the α-synuclein (α-syn) gene. Mutant α-syn expression increases the vulnerability of neurons to exogenous insults. In this... -
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