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Effects of resveratrol on the insulin signaling pathway of obese mice

Hong HJ, Kang W, Kim DG, Lee DH, Lee Y, Han CH

The present study was conducted to investigate the effects of resveratrol on the insulin signaling pathway in the liver of obese mice. To accomplish this, we administered resveratrol to high...
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Knockdown of Bcl-xL Enhances Growth-Inhibiting and Apoptosis-Inducing Effects of Resveratrol and Clofarabine in Malignant Mesothelioma H-2452 Cells

Lee YJ, Hwang IS, Lee YJ, Lee CH, Kim SH, Nam HS, Choi YJ, Lee SH

Mcl-1 and Bcl-xL, key anti-apoptotic proteins of the Bcl-2 family, have attracted attention as important molecules in the cell survival and drug resistance. In this study, we investigated whether inhibition...
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Resveratrol inhibits foam cell formation via NADPH oxidase 1-mediated reactive oxygen species and monocyte chemotactic protein-1

Park DW, Baek K, Kim JR, Lee JJ, Ryu SH, Chin BR, Baek SH

Resveratrol is a polyphenolic compound in red wine that has anti-oxidant and cardioprotective effects in animal models. Reactive oxygen species (ROS) and monocyte chemotactic protein-1 (MCP-1) play key roles in...
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Inhibition of cell proliferation by a resveratrol analog in human pancreatic and breast cancer cells

Hong YB, Kang HJ, Kim HJ, Rosen EM, Dakshanamurthy S, Rondanin R, Baruchello R, Grisolia G, Daniele S, Bae I

Resveratrol has been reported to possess cancer preventive properties. In this study, we analyzed anti-tumor activity of a newly synthesized resveratrol analog, cis-3,4',5-trimethoxy-3'-hydroxystilbene (hereafter called 11b) towards breast and pancreatic...
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Resveratrol protects SH-SY5Y neuroblastoma cells from apoptosis induced by dopamine

Lee MK, Kang SJ, Poncz M, Song KJ, Park KS

  • KMID: 1047089
  • Exp Mol Med.
  • 2007 Jun;39(3):376-384.
Dopamine (DA) is an oxidant that may contribute to the degeneration of dopaminergic neurons. The present study demonstrates that DA-induced cytotoxicity in human-derived neurotypic cells, SH-SY5Y, is prevented by resveratrol,...
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Resveratrol stimulates glucose transport in C2C12 myotubes by activating AMP-activated protein kinase

Park CE, Kim MJ, Lee JH, Min BI, Bae H, Choe W, Kim SS, Ha J

  • KMID: 1094663
  • Exp Mol Med.
  • 2007 Apr;39(2):222-229.
trans-Resveratrol (t-RVT), a naturally occurring polyphenol found in Polygonum cuspidatum, grape, and red wine, has been reported to have anti- inflammatory, cardioprotective, and cancer chemopreventive properties. However antidiabetic effect of...
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Retinal Protective Effects of Resveratrol via Modulation of Nitric Oxide Synthase on Oxygen-induced Retinopathy

Kim WT, Suh ES

PURPOSE: Retinopathy of prematurity (ROP) is one of the leading causes of blindness, with retinal detachment occurring due to oxygen toxicity in preterm infants. Recently, advances in neonatal care have...
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