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Chronic Pulmonary Disease Due to Mycobacterium monacense Infection: The First Case from Iran

Shojaei H, Hashemi A, Heidarieh , Hosseini N, Daei Naser A

We herein report a case in which the recently characterized species Mycobacterium monacense was isolated from the sputum of an Iranian patient. This case represents the first isolation of M....
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Prevalence of Chronic Sputum and Associated Factors in Korean Adults

Lee BR, Kim YI, Kim S, Lee HS, Yoon SH, Yu JY, Ban HJ, Kwon YS, Oh IJ, Kim KS, Kim YC, Lim SC

Chronic sputum is a troublesome symptom in many respiratory diseases. The prevalence of chronic sputum varies from 1.2% to 13% according to the country. The purpose of this study was...
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Evaluation of Propidium Monoazide Real-Time PCR for Early Detection of Viable Mycobacterium tuberculosis in Clinical Respiratory Specimens

Kim YJ, Lee SM, Park BK, Kim SS, Yi J, Kim HH, Lee EY, Chang CL

BACKGROUND: Conventional acid-fast bacilli (AFB) staining cannot differentiate viable from dead cells. Propidium monoazide (PMA) is a photoreactive DNA-binding dye that inhibits PCR amplification by DNA modification. We evaluated whether...
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Random amplified polymorphic DNA (RAPD) analysis of Mycobacterium tuberculosis strains in India

Singh JP, Verma R, Chaudhuri

The usefulness of random amplification of polymorphic DNA (RAPD) analysis for typing Indian strains of M. tuberculosis was investigated. M. tuberculosis H37Rv, M. tuberculosis DT and 42 clinical isolates of M. tuberculosis were subjected...
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Mycobacterium avium lung disease combined with a bronchogenic cyst in an immunocompetent young adult

Kwon YS, Han J, Jung KH, Kim JH, Koh WJ

We report a very rare case of a bronchogenic cyst combined with nontuberculous mycobacterial pulmonary disease in an immunocompetent patient. A 21-year-old male was referred to our institution because of...
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Relationships between High-Resolution Computed Tomography, Lung Function and Bacteriology in Stable Bronchiectasis

Lee JH, Kim YK, Kwag HJ, Chang JH

To determine the relationship between high-resolution computed tomography (HRCT) findings, lung function, and bacteriology in bronchiectasis, we conducted a retrospective study of 49 Korean patients with stable bronchiectasis. To quantify...
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Recent Trends in Clinically Significant Nontuberculous Mycobacteria Isolates at a Korean General Hospital

Kim HS, Lee Y, Lee S, Kim YA, Sun YK

Lung disease caused by nontuberculous mycobacteria (NTM) represents an increasing proportion of all mycobacterial diseases. We investigated recent occurrences of NTM and evaluated the clinical significance of NTM isolates from...
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The Combination of Real-Time PCR and HPLC for the Identification of Non-Tuberculous Mycobacteria

Park JS, Choi JI, Lim JH, Ahn JJ, Jegal Y, Seo KW, Ra SW, Jeon JB, Lee SH, Kim SR, Jeong J

We used HPLC and AdvanSure real-time PCR (LG Life Sciences, Korea) to retrospectively analyze non-tuberculous mycobacteria (NTM) in 133 clinical specimens. The specimens were culture-positive for NTM and the HPLC...
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A Case of Atypical Skull Base Osteomyelitis with Septic Pulmonary Embolism

Lee SJ, Weon YC, Cha HJ, Kim SY, Seo KW, Jegal Y, Ahn JJ, Ra SW

Skull base osteomyelitis (SBO) is difficult to diagnose when a patient presents with multiple cranial nerve palsies but no obvious infectious focus. There is no report about SBO with septic...
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Diagnostic Accuracy of Notified Cases as Pulmonary Tuberculosis in Private Sectors of Korea

Jeong I, Kim HJ, Kim J, Oh SY, Lee JB, Bai JY, Lee CH

The diagnostic accuracy of the data reported in the Korean tuberculosis surveillance system (KTBS) has not been adequately investigated. We reviewed the clinical data of pulmonary tuberculosis (PTB) cases notified...
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Detection of Mycobacterium tuberculosis in clinical samples from patients with tuberculosis or other pulmonary diseases by polymerase chain reaction

Yoon KH, Cho SN, Lee TY, Cheon SH, Chang J, Kim SK, Chong Y, Chung DH, Lee WY, Kim JD

Polymerase chain reaction (PCR) using primers targeting the IS6110 repetitive sequence was employed to detect Mycobacterium tuberculosis in 228 samples from patients with tuberculosis or other pulmonary diseases and controls,...
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Clinical Investigation of Cavitary Tuberculosis and Tuberculous Pneumonia

Lee KM, Choe KH, Kim SJ

BACKGROUND: The radiographic characteristics of tuberculous pneumonia in adults are similar to primary tuberculosis that occurs in childhood, and upper lobe cavitary tuberculosis is the hallmark of postprimary tuberculosis....
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Evaluation of Peptide Nucleic Acid Probe-based Real-time PCR for Detection of Mycobacterium tuberculosis Complex and Nontuberculous Mycobacteria in Respiratory Specimens

Choi YJ, Kim HJ, Shin HB, Nam HS, Lee SH, Park JS, Park KS, Baek KA

BACKGROUND: A peptide nucleic acid (PNA) probe-based real-time PCR (PNAqPCR(TM) TB/NTM detection kit; PANAGENE, Korea) assay has been recently developed for the simultaneous detection of Mycobacterium tuberculosis complex (MTBC) and...
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Role of Atypical Pathogens and the Antibiotic Prescription Pattern in Acute Bronchitis: A Multicenter Study in Korea

Park S, Oh KC, Kim KS, Song KT, Yoo KH, Shim YS, Lee YJ, Lee MG, Yun JU, Kim HS, Kim YH, Lee WJ, Kim DI, Cha HG, Lee JM, Seo JS, Jung KS

The role of atypical bacteria and the effect of antibiotic treatments in acute bronchitis are still not clear. This study was conducted at 22 hospitals (17 primary care clinics and...
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Diagnosis and Treatment of Nontuberculous Mycobacterial Lung Disease

Kwon YS, Koh WJ

Nontuberculous mycobacteria (NTM) are ubiquitous organisms; their isolation from clinical specimens does not always indicate clinical disease. The incidence of NTM lung diseases has been increasing worldwide. Although the geographic...
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Disseminated Mycobacterium kansasii Infection Associated with Skin Lesions: A Case Report and Comprehensive Review of the Literature

Han SH, Kim KM, Chin BS, Choi SH, Lee HS, Kim MS, Jeong SJ, Choi HK, Kim CO, Choi JY, Song YG, Kim JM

Mycobacteruim kansasii occasionally causes disseminated infection with poor outcome in immunocompromised patients. We report the first case of disseminated M. kansasii infection associated with multiple skin lesions in a 48-yr-old...
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Real-Time Nucleic Acid Sequence-Based Amplification to Predict the Clinical Outcome of Invasive Aspergillosis

Kim SH, Park C, Kwon EY, Shin NY, Kwon JC, Park SH, Choi SM, Lee DG, Choi JH, Yoo JH

Monitoring the response to therapy for invasive aspergillosis (IA) is essential for the management of patients with hematologic diseases. We evaluated the correlation between the outcome of real-time nucleic acid...
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Assessment of the Quantitative Ability of AdvanSure TB/NTM Real-Time PCR in Respiratory Specimens by Comparison with Phenotypic Methods

Lee H, Park KG, Lee G, Park J, Park YG, Park YJ

Accurate quantification of mycobacterial load is important to evaluate disease severity and to monitor the course of treatment in tuberculosis (TB). We evaluated the quantitative capability of the AdvanSure TB/NTM...
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A Case of Emphysematous Gastritis in a Patient with End-stage Renal Disease

Ko GJ, Park KS, Park TW, Woo MY, Han KJ, Lee SC, Cho JH

Emphysematous gastritis is a rare infection of the stomach wall with high mortality rate. It is caused by gas forming organisms and may arise by local spread through the mucosa...
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Ventilator-associated Pneumonia with Circuit Changes Every 7 Days versus Every 14 Days

Choi JS, Yeon JH

PURPOSE: To determine whether the practice of not routinely changing ventilator circuits in patients who require prolonged mechanical ventilation is associated with ventilator-associated pneumonia (VAP). METHODS: Patients were divided into two...
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