- Cytolytic activity of mitogen activated old and young mouse spleen cells against tumor target cells expressing high or low levels of Fas antigen
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Saxena RK, Adler WH
- KMID: 755042
- Exp Mol Med.
- 1999 Sep;31(3):137-141.
Sensitivity of Fas expressing tumor cells (high levels in Hut78 & Jurkat; low levels in P815) toward the cytotoxic Con-A (5 microg/ml) activated spleen cells from young (12 to 16 week old... -
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- Production of interferon-gamma and interleukin-4 by splenocytes in mice infected with Paragonimus westermani
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Shin MH, Min DY
- KMID: 1715354
- Korean J Parasitol.
- 1996 Sep;34(3):185-189.
- doi: 10.3347/kjp.1996.34.3.185
The TH cytokine responses of spleen cells stimulated with Con A from mice infected with Paragonimus westermani were examined. The spleen cell culture supernatants were assayed for TH1-specific IFN-gamma and... -
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- Differential expression of leukocyte common antigen in human fetal lymphoid organs
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Coh JH, Chi JG
- KMID: 1129860
- J Korean Med Sci.
- 1995 Feb;10(1):14-23.
- doi: 10.3346/jkms.1995.10.1.14
To investigate the differential expression of various types of leukocyte common antigen (LCA) isoforms during development, we analyzed human fetal lymphoid organs, including the thymus, liver, spleen, and bone marrow... -
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- Sequential analysis of cell differentials and IFN-gamma production of splenocytes from mice infected with Toxoplasma gondii
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Lee YH, Shin DW, Kasper LH
- KMID: 1715240
- Korean J Parasitol.
- 2000 Jun;38(2):85-90.
- doi: 10.3347/kjp.2000.38.2.85
To assess the relationship between the changes of cellular components and the production of Th1 cytokine in the immune tissue, inbred C57BL/6 mice were orally infected with 40 cysts of... -
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- DNA-mediated immunization of mice with plasmid encoding HBs antigen
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Yoon SJ, Park JW, Ahn SY, Choe BK, Suh MH
- KMID: 648079
- J Korean Med Sci.
- 1999 Apr;14(2):187-192.
- doi: 10.3346/jkms.1999.14.2.187
In order to develop an experimental DNA vaccine for the prevention and treatment of hepatitis B virus infection, hepatitis B virus surface antigen (HBsAg) DNA was subcloned into an E.... -
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- Trichinella spiralis Infection Suppressed Gut Inflammation with CD4+CD25+Foxp3+ T Cell Recruitment
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Cho MK, Park MK, Kang SA, Choi SH, Ahn SC, Yu HS
- KMID: 1792137
- Korean J Parasitol.
- 2012 Dec;50(4):385-390.
In order to know the effect of pre-existing Trichinella spiralis infection on experimentally induced intestinal inflammation and immune responses, we induced colitis in T. spiralis-infected mice and observed the severity... -
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- The critical time of avian leukosis virus subgroup J-mediated immunosuppression during early stage infection in specific pathogen-free chickens
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Wang F, Wang X, Chen H, Liu J, Cheng Z
- KMID: 1067395
- J Vet Sci.
- 2011 Sep;12(3):235-241.
- doi: 10.4142/jvs.2011.12.3.235
The critical time of avian leukosis virus subgroup J (ALV-J)-mediated immunosuppression was determined by body weight, relative immune organ weight, histopathology, and presence of group specific antigen and antibodies in... -
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- Antitumor immunity induced by tumor cells engineered to express a membrane-bound form of IL-2
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Chang MR, Lee WH, Choi JW, Park SO, Paik SG, Kim YS
- KMID: 1056237
- Exp Mol Med.
- 2005 Jun;37(3):240-249.
Transduction of cytokine gene into tumor cells is a promising method of tumor therapy, but the value is limited by accompanying side effects. To focus antitumor immune response to tumor... -
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- Downregulation of Orai1 expression in the airway alleviates murine allergic rhinitis
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Wang Y, Lin L, Zheng C
- KMID: 1245261
- Exp Mol Med.
- 2012 Mar;44(3):177-190.
- doi: 10.3858/emm.2012.44.3.013
Orai1 is the key subunit of the Ca2+-release-activated Ca2+ channel. Our previous report has demonstrated that Orai1 expression in the airway was upregulated in the ovalbumin (OVA)-induced allergic rhinitis (AR)... -
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- STAT6 Expression and IL-13 Production in Association with Goblet Cell Hyperplasia and Worm Expulsion of Gymnophalloides seoi from C57BL/6 Mice
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Lee JJ, Kim D, Pyo KH, Kim MK, Kim HJ, Chai JY, Shin EH
- KMID: 1792154
- Korean J Parasitol.
- 2013 Oct;51(5):589-594.
In intestinal helminth infections, Th2 immune respones are generally associated with mucin secretion for worm expulsion from the host intestine. In particular, IL-4 and IL-13 are the important cytokines related... -
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- Parasitic Helminth Cystatin Inhibits DSS-Induced Intestinal Inflammation Via IL-10+F4/80+ Macrophage Recruitment
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Jang SW, Cho MK, Park MK, Kang SA, Na BK, Ahn SC, Kim DH, Yu HS
- KMID: 1715647
- Korean J Parasitol.
- 2011 Sep;49(3):245-254.
- doi: 10.3347/kjp.2011.49.3.245
Many immune down-regulatory molecules have been isolated from parasites, including cystatin (cystain protease inhibitor). In a previous study, we isolated and characterized Type I cystatin (CsStefin-1) of the liver fluke,... -
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- Changes of splenocyte IFN-gamma mRNA synthesis in rats infected with Paragonimus westermani
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Cho JK, Kwon HS, Joo KH, Lee JS, Cho SW
- KMID: 1715257
- Korean J Parasitol.
- 1999 Dec;37(4):285-287.
- doi: 10.3347/kjp.1999.37.4.285
Changes in the expression level of splenocyte IFN-gamma mRNA of Sprague-Dawley (SD) rats infected with Paragonimus westermani were analyzed by competitive reverse transcription-polymerase chain reaction (RT-PCR) followed by southern... -
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- Experimental Murine Fascioliasis Derives Early Immune Suppression with Increased Levels of TGF-beta and IL-4
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Chung JY, Bae YA, Yun DH, Yang HJ, Kong Y
- KMID: 1792122
- Korean J Parasitol.
- 2012 Dec;50(4):301-308.
In fascioliasis, T-helper 2 (Th2) responses predominate, while little is known regarding early immune phenomenon. We herein analyzed early immunophenotype changes of BALB/c, C57BL/6, and C3H/He mice experimentally infected with... -
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- Splenic lymphoid change in abdominal neoplasmic patients: analysis of 121 cases
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Cho HJ, Ko IH
- KMID: 644800
- J Korean Med Sci.
- 1994 Jun;9(3):230-238.
- doi: 10.3346/jkms.1994.9.3.230
Because the spleen is likely to play a specific role in immunity, we have tried to observe the influence of the abdominal neoplasms on splenic lymphoid tissue as well as... -
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- T Regulatory Cell Responses to Immunization with a Soluble Egg Antigen in Schistosoma mansoni-Infected Mice
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El-Ahwany , Bauiomy I, Nagy F, Zalat R, Mahmoud O, Zada S
- KMID: 1364892
- Korean J Parasitol.
- 2012 Mar;50(1):29-35.
- doi: 10.3347/kjp.2012.50.1.29
The aim of the study is to characterize the phenotypes of CD4+ CD25+ T regulatory cells within the liver granulomas and association with both Foxp-3 gene expression and splenic cytokines.... -
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- Resistance to Toxoplasma gondii Infection in Mice Treated with Silk Protein by Enhanced Immune Responses
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Moon JH, Pyo KH, Jung BK, Chun HS, Chai JY, Shin EH
- KMID: 1715657
- Korean J Parasitol.
- 2011 Sep;49(3):303-308.
- doi: 10.3347/kjp.2011.49.3.303
This study investigated whether elevated host immune capacity can inhibit T. gondii infection. For this purpose, we used silk protein extracted from Bombyx mori cocoons as a natural supplement to... -
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- A Novel Recombinant BCG Vaccine Encoding Eimeria tenella Rhomboid and Chicken IL-2 Induces Protective Immunity Against Coccidiosis
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Wang Q, Chen L, Li J, Zheng J, Cai N, Gong P, Li S, Li H, Zhang X
- KMID: 1792178
- Korean J Parasitol.
- 2014 Jun;52(3):251-256.
A novel recombinant Bacille Calmette-Guerin (rBCG) vaccine co-expressed Eimeria tenella rhomboid and cytokine chicken IL-2 (chIL-2) was constructed, and its efficacy against E. tenella challenge was observed. The rhomboid gene... -
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- The effects of cyclophosphamide treatment on the pathogenesis of subgroup J avian leukosis virus (ALV-J) infection in broiler chickens with Marek's disease virus exposure
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Kim Y, Brown TP, Pantin-Jackwood MJ
- KMID: 1094687
- J Vet Sci.
- 2004 Mar;5(1):49-58.
Studies were performed to determine the effects of Bcell suppression on the pathogenesis of Subgroup J avian leukosis virus (ALV-J) in broiler chickens. Neonatal chickens were treated with cyclophosphamide (CY)... -
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- Effects of iNOS inhibitor on IFN-gamma production and apoptosis of splenocytes in genetically different strains of mice infected with Toxoplasma gondii
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Kang KM, Lee GS, Lee JH, Choi IW, Shin DW, Lee YH
- KMID: 1720487
- Korean J Parasitol.
- 2004 Dec;42(4):175-183.
- doi: 10.3347/kjp.2004.42.4.175
To evaluate the role of nitric oxide (NO) in IFN-gamma production and apoptosis of splenocytes in genetically different strains of mice with toxoplasmosis, BALB/c (a toxoplasmosis resistant strain) and C57BL/6... -
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