- Cholesterol conjugated spermine as a delivery modality of antisense oligonucleotide
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Im YK, Kim MS, Yoo H
- KMID: 1709609
- Int J Oral Biol.
- 2013 Dec;38(4):155-160.
The major issue in the development of nucleic acid based therapeutics is the inefficient delivery of these agents into cells. We prepared cholesterol conjugated spermine and evaluated its usefulness as... -
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- Relaxation Responses of Isolated Rabbit Seminal Vesicle to Polyamines
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Myung SC, Lee SY, Kang GH, Keum EM, Lee MY, Kim SC
- KMID: 2293954
- Korean J Urol.
- 2005 Feb;46(2):169-173.
PURPOSE: This study was designed to investigate the effects of polyamines on rabbit seminal vesicular contractility. MATERIALS AND METHODS: The polyamines; putrescine, spermidine and spermine, were added to deepithelized and precontracted... -
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- Analysis of interaction between intracellular spermine and transient receptor potential canonical 4 channel: multiple candidate sites of negatively charged amino acids for the inward rectification of transient receptor potential canonical 4
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Kim J, Moon SH, Kim T, Ko J, Jeon YK, Shin YC, Jeon JH, So I
- KMID: 2466574
- Korean J Physiol Pharmacol.
- 2020 Jan;24(1):101-110.
- doi: 10.4196/kjpp.2020.24.1.101
Transient receptor potential canonical 4 (TRPC4) channel is a nonselective calcium-permeable cation channels. In intestinal smooth muscle cells, TRPC4 currents contribute more than 80% to muscarinic cationic current (mIcat). With... -
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- (3H)MK-801 binding to the synaptic membranes of rat forebrains: Age-related regulation by glutamate, glycine and spermine
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Cho J, Kong JY
- KMID: 1554547
- Korean J Physiol Pharmacol.
- 1997 Apr;1(2):117-125.
The N-methyl-D-aspartate (NMDA) receptor-mediated glutamatergic neurotransmission is involved in synaptic plasticity, developmental processes, learning and memory and many neuropathological disorders including age-related diseases. In the present study, regulation of the NMDA receptor properties by... -
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- Intrinsic Gating in Inward Rectifier Potassium Channels (Kir2.1) with Low Polyamine Affinity Generated by Site Directed Mutagenesis
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So I, Ashmole I, Soh H, Park C, Spencer P, Leyland M, Stanfield
- KMID: 2071587
- Korean J Physiol Pharmacol.
- 2003 Jun;7(3):131-142.
We have studied mutant forms of Kir2.1 in which an aspartate residue (D172), important for gating by intracellular polyamines, is replaced by one of three basic residues (Arg, Lys or... -
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- Effects of dexamethasone and DHEA on the changes of glutamate and polyamine uptake in rat astrocytes by lipopolysaccharide and antimycin A
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Choi SH, Lee B, Shin KH, Min BH, Chun YS, Chun BG
- KMID: 1554128
- Korean J Physiol Pharmacol.
- 1999 Apr;3(2):137-146.
Interactions among dexamethasone, dehydroepiandrosterone (DHEA), lipopolysaccharide (LPS), and antimycin A on the glutamate uptake and the polyamine uptake were investigated in primary cultures of rat cerebral cortical astrocytes to examine the effects of... -
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- Urinary Polyamine Profiles and Benign Prostatic Hyperplasia
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Hong SJ, Chung BH, Seo JW, Chung BC, Park DS, Lee DH
- KMID: 1663287
- Korean J Urol.
- 1996 Dec;37(12):1398-1403.
Polyamines are non-specific marker of cellular proliferation in many malignant tumors, and it is also increase in certain benign conditions. We measured the urinary polyamines to investigate the possibility as... -
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- Polyamines and Their Metabolites as Diagnostic Markers of Human Diseases
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Park MH, Igarashi K
- KMID: 2170679
- Biomol Ther.
- 2013 Jan;21(1):1-9.
Polyamines, putrescine, spermidine and spermine, are ubiquitous in living cells and are essential for eukaryotic cell growth. These polycations interact with negatively charged molecules such as DNA, RNA, acidic proteins... -
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- Relaxant Effect of Spermidine on Acethylcholine and High K+-induced Gastric Contractions of Guinea-Pig
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Kim YC, Sim JH, Choi W, Kim CH, You RY, Xu WX, Lee SJ
- KMID: 1486144
- Korean J Physiol Pharmacol.
- 2008 Apr;12(2):59-64.
- doi: 10.4196/kjpp.2008.12.2.59
In our previous study, we found that spermine and putrescine inhibited spontaneous and acetylcholine (ACh)-induced contractions of guinea-pig stomach via inhibition of L-type voltage- dependent calcium current (VDCCL). In this... -
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- Effects of Polyamines on TNFalpha- or Tamoxifen-induced Apoptosis in Human Breast Cancer Cells
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Kim JY, Kim KY, Lee KH, Hong KW, Kim BG
- KMID: 1804428
- Cancer Res Treat.
- 2001 Oct;33(5):385-391.
PURPOSE: To investigate the effects of polyamines on tumor necrosis factor alpha (TNFalpha)-or tamoxifen (TAM)-induced apoptosis in estrogen receptor (ER)-positive MCF- 7 and ER-negative MDA-MB-231 human breast cancer cells. MATERIALS AND... -
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- Acrolein Is a Hazardous Air Pollutant
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- KMID: 2299509
- Korean J Asthma Allergy Clin Immunol.
- 2011 Jun;31(2):84-90.
Acrolein (2-propenal) is a highly reactive alpha, beta unsaturated aldehyde, and a product of lipid peroxidation reactions. It is formed from carbohydrates, amino acids, vegetable oils and animal fats during... -
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- The Mechanism on the Glutamate-evoked Release of [3H) norepinephrine in Rat Cortex Slices
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Shin BS, Song DW, Lee SH, Seo MW, Kim YH
- KMID: 2066064
- J Korean Neurol Assoc.
- 1996 Mar;14(1):238-250.
Glutamate Is the predominant excitatory neurotransmitter in the mammalian CNS. To elucidate the influence of glutamate on the noradrenergic neurotransmission in rat cortex, we examined the effects of agents that... -
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- Influence of Nitric Oxide Donor on the Regulation of ATP-sensitive K+ Channel Activity in Cardiac Myocytes
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Ju JM, Shin DH, Lee WS, Park HW, Cho JG, Kim JH
- KMID: 2116759
- Chonnam Med J.
- 2002 Jun;38(2):135-145.
It was investigated that effects of nitric oxide donors on the ATP-sensitive K+ channel (KATP channel) in isolated mouse ventricular cardiac myocytes using patch clamp techniques. In perforated whole-cell patches,... -
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- Effect of Melatonin on the Changes of Hippocampal Polyamine Content and Neuronal Damage Following Transient Global Ischemia in Mongolian Gerbil: a Study of the Differences of Pre- and Post-ischemic Treatment
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Lee SR, Cheun JK
- KMID: 2091626
- Korean J Anesthesiol.
- 2001 May;40(5):664-670.
- doi: 10.4097/kjae.2001.40.5.664
BACKGROUND: We designed this study to examine whether melatonin has a neuroprotective effect against hippocampal neuronal damage following transient global ischemia in a gerbil. Because polyamine is known to participate... -
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- Effect of Melatonin on Brain Polyamine Contents and Hippocampal Neuronal Damage after Transient Global Ischemia in Mongolian Gerbil
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Jang YS, Kim DH, Suh YS, Yim MB, Lee SR
- KMID: 1932162
- Korean J Cerebrovasc Dis.
- 2002 Mar;4(1):46-51.
OBJECTIVES: This study was designed to examine whether melatonin has a neuroprotective effect against hippocampal neuronal damage following transient global ischemia in a gerbil. Polyamine is known to play a... -
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- Effect of Ibuprofen on the Changes of Polyamine Level and Neuronal Cell Damage after Transient Global Ischemia in Gerbil
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Lee SH, Lee SR, Lim JG, Lee H, Yi SD
- KMID: 2342971
- J Korean Neurol Assoc.
- 2002 May;20(3):265-272.
BACKGROUND: In brain ischemia, increased arachidonic acid metabolism can play important roles in neuronal dam-age. Ibuprofen was reported to have a protective role against neuronal damage in focal brain ischemia... -
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- Arginase II inhibition prevents interleukin-8 production through regulation of p38 MAPK phosphorylation activated by loss of mitochondrial membrane potential in nLDL-stimulated hAoSMCs
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Koo BH, Yi BG, Jeong MS, Kwon SH, Hoe KL, Kwon YG, Won MH, Kim YM, Ryoo S
- KMID: 2440020
- Exp Mol Med.
- 2018 Feb;50(2):e438.
- doi: 10.1038/emm.2017.254
Arginase inhibition exhibits beneficial effects in vascular endothelial and smooth muscle cells. In human aortic smooth muscle cells (hAoSMCs), native low-density lipoprotein (nLDL) induced the production of interleukin-8 (IL-8) that... -
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- Effects of Endothelium-derived Relaxing Factors on the Regulation of ATP-sensitive Potassium Channel Activity in Cardiac Myocytes
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Ju JM, Shin DH, Jeong HS, Park HW, Cho JG, Kim JH
- KMID: 2093880
- Korean Circ J.
- 2003 May;33(5):420-430.
- doi: 10.4070/kcj.2003.33.5.420
BACKGROUND AND OBJECTIVES: Effects of the three major endothelium-derived relaxing factors (EDRFs), namely nitric oxide (NO), prostacyclin (PGI2), and 11, 12-epoxyeicosatrienoic acid (EET) on the ATP-sensitive potassium channel (K ATP... -
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