- Exogenous spermidine ameliorates tubular necrosis during cisplatin nephrotoxicity
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Yoon SP, Kim J
- KMID: 2447012
- Anat Cell Biol.
- 2018 Sep;51(3):189-199.
- doi: 10.5115/acb.2018.51.3.189
The hallmark of cisplatin-induced acute kidney injury is the necrotic cell death in the kidney proximal tubules. However, an effective approach to limit cisplatin nephrotoxicity remains unknown. Spermidine is a... -
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- Spermidine is protective against kidney ischemia and reperfusion injury through inhibiting DNA nitration and PARP1 activation
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Kim J
- KMID: 2390481
- Anat Cell Biol.
- 2017 Sep;50(3):200-206.
- doi: 10.5115/acb.2017.50.3.200
Kidney ischemia and reperfusion injury (IRI) is associated with a high mortality rate, which is attributed to tubular oxidative and nitrative stresses; however, an effective approach to limit IRI remains... -
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- Relaxant Effect of Spermidine on Acethylcholine and High K+-induced Gastric Contractions of Guinea-Pig
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Kim YC, Sim JH, Choi W, Kim CH, You RY, Xu WX, Lee SJ
- KMID: 1486144
- Korean J Physiol Pharmacol.
- 2008 Apr;12(2):59-64.
- doi: 10.4196/kjpp.2008.12.2.59
In our previous study, we found that spermine and putrescine inhibited spontaneous and acetylcholine (ACh)-induced contractions of guinea-pig stomach via inhibition of L-type voltage- dependent calcium current (VDCCL). In this... -
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- Urinary Polyamine Profiles and Benign Prostatic Hyperplasia
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Hong SJ, Chung BH, Seo JW, Chung BC, Park DS, Lee DH
- KMID: 1663287
- Korean J Urol.
- 1996 Dec;37(12):1398-1403.
Polyamines are non-specific marker of cellular proliferation in many malignant tumors, and it is also increase in certain benign conditions. We measured the urinary polyamines to investigate the possibility as... -
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- Spermidine Protects against Oxidative Stress in Inflammation Models Using Macrophages and Zebrafish
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Jeong JW, Cha HJ, Han MH, Hwang SJ, Lee DS, Yoo JS, Choi IW, Kim S, Kim HS, Kim GY, Hong SH, Park C, Lee HJ, Choi YH
- KMID: 2429054
- Biomol Ther.
- 2018 Mar;26(2):146-156.
- doi: 10.4062/biomolther.2016.272
Spermidine is a naturally occurring polyamine compound that has recently emerged with anti-aging properties and suppresses inflammation and oxidation. However, its mechanisms of action on anti-inflammatory and antioxidant effects have... -
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- Relaxation Responses of Isolated Rabbit Seminal Vesicle to Polyamines
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Myung SC, Lee SY, Kang GH, Keum EM, Lee MY, Kim SC
- KMID: 2293954
- Korean J Urol.
- 2005 Feb;46(2):169-173.
PURPOSE: This study was designed to investigate the effects of polyamines on rabbit seminal vesicular contractility. MATERIALS AND METHODS: The polyamines; putrescine, spermidine and spermine, were added to deepithelized and precontracted... -
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- Mitochondrial Quality Control in the Heart: New Drug Targets for Cardiovascular Disease
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Oh CM, Ryu D, Cho S, Jang Y
- KMID: 2471778
- Korean Circ J.
- 2020 May;50(5):395-405.
- doi: 10.4070/kcj.2019.0416
Despite considerable efforts to prevent and treat cardiovascular disease (CVD), it has become the leading cause of death worldwide. Cardiac mitochondria are crucial cell organelles responsible for creating energy-rich ATP... -
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- Association of dexamethasone-induced apoptosis of G|1-arrest of human leukemic CEM cells with polyamine deficit
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Choi SH, Lee JA, Chae YS, Min BH, Chun YS, Chun BG
- KMID: 2071517
- Korean J Physiol Pharmacol.
- 1997 Aug;1(4):457-466.
The effects of DFMO or/and putrescine on the dexamethasone-induced apoptosis of CEM cells were studied to investigate the role of polyamines in anti-leukemic glucocorticoid action. Dexamethasone-induced apoptosis was preceded by significant decreases of cellular... -
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- Identification of Wild Yeast Strains and Analysis of Their beta-Glucan and Glutathione Levels for Use in Makgeolli Brewing
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Kang SH, Kim HR, Kim JH, Ahn BH, Kim TW, Lee JE
- KMID: 2408967
- Mycobiology.
- 2014 Dec;42(4):361-367.
- doi: 10.5941/MYCO.2014.42.4.361
Makgeolli, also known as Takju, is a non-filtered traditional Korean alcoholic beverage that contains various floating matter, including yeast cells, which contributes to its high physiological functionality. In the present... -
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- Polyamines and Their Metabolites as Diagnostic Markers of Human Diseases
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Park MH, Igarashi K
- KMID: 2170679
- Biomol Ther.
- 2013 Jan;21(1):1-9.
Polyamines, putrescine, spermidine and spermine, are ubiquitous in living cells and are essential for eukaryotic cell growth. These polycations interact with negatively charged molecules such as DNA, RNA, acidic proteins... -
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- Proteomic Analysis of Hepatic Ischemia and Reperfusion Injury in Mice
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Cho EH, Sung JH, Koh PO
- KMID: 1458942
- Lab Anim Res.
- 2010 Mar;26(1):69-74.
- doi: 10.5625/lar.2010.26.1.69
Hepatic ischemia/reperfusion (I/R) injury is an inevitable consequence during liver surgery. I/R injury induces serious hepatic dysfunction and failure. In this study, we identified proteins that were differentially expressed between... -
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- Effects of dexamethasone and DHEA on the changes of glutamate and polyamine uptake in rat astrocytes by lipopolysaccharide and antimycin A
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Choi SH, Lee B, Shin KH, Min BH, Chun YS, Chun BG
- KMID: 1554128
- Korean J Physiol Pharmacol.
- 1999 Apr;3(2):137-146.
Interactions among dexamethasone, dehydroepiandrosterone (DHEA), lipopolysaccharide (LPS), and antimycin A on the glutamate uptake and the polyamine uptake were investigated in primary cultures of rat cerebral cortical astrocytes to examine the effects of... -
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- Acrolein Is a Hazardous Air Pollutant
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- KMID: 2299509
- Korean J Asthma Allergy Clin Immunol.
- 2011 Jun;31(2):84-90.
Acrolein (2-propenal) is a highly reactive alpha, beta unsaturated aldehyde, and a product of lipid peroxidation reactions. It is formed from carbohydrates, amino acids, vegetable oils and animal fats during... -
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- Effect of Melatonin on the Changes of Hippocampal Polyamine Content and Neuronal Damage Following Transient Global Ischemia in Mongolian Gerbil: a Study of the Differences of Pre- and Post-ischemic Treatment
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Lee SR, Cheun JK
- KMID: 2091626
- Korean J Anesthesiol.
- 2001 May;40(5):664-670.
- doi: 10.4097/kjae.2001.40.5.664
BACKGROUND: We designed this study to examine whether melatonin has a neuroprotective effect against hippocampal neuronal damage following transient global ischemia in a gerbil. Because polyamine is known to participate... -
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- Effect of Melatonin on Brain Polyamine Contents and Hippocampal Neuronal Damage after Transient Global Ischemia in Mongolian Gerbil
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Jang YS, Kim DH, Suh YS, Yim MB, Lee SR
- KMID: 1932162
- Korean J Cerebrovasc Dis.
- 2002 Mar;4(1):46-51.
OBJECTIVES: This study was designed to examine whether melatonin has a neuroprotective effect against hippocampal neuronal damage following transient global ischemia in a gerbil. Polyamine is known to play a... -
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- Involvement of Polyamine in Growth Hormine Secretion from the GH3 Cells
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Lee JY, Kim BK
- KMID: 2331104
- J Korean Soc Endocrinol.
- 1998 Sep;13(3):313-323.
BACKGROUNDS: Polyamines are known to be essential for cell growth and differentiation. Recently, possible roles of the polyamine in signal transduction as neurotransmitter, modulator, or second messenger are suggested in... -
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