- Expression Pattern of Smad Proteins in Diffuse Large B-cell Lymphomas
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Go JH
- KMID: 2073840
- Korean J Pathol.
- 2004 Oct;38(5):301-305.
BACKGROUND: Smad proteins mediate the cellular signaling from members of transforming growth factor-beta family (TGF-beta s). Smads 2 and 3 transmit signals from TGF-beta and activin, and Smads 1, 5,... -
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- The Role of Tripartite Motif Family Proteins in TGF-β Signaling Pathway and Cancer
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Lee HJ
- KMID: 2447447
- J Cancer Prev.
- 2018 Dec;23(4):162-169.
- doi: 10.15430/JCP.2018.23.4.162
TGF-β signaling plays a tumor suppressive role in normal and premalignant cells but promotes tumor progression during the late stages of tumor development. The TGF-β signaling pathway is tightly regulated... -
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- Altered Expression of Smad Proteins in T or NK-cell Lymphomas
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Go JH
- KMID: 1972647
- Cancer Res Treat.
- 2008 Dec;40(4):197-201.
PURPOSE: Smad proteins mediate cellular signaling through the transforming growth factor-beta family (TGF-beta s). Smads 2 and 3 transmit signals from TGF-beta, and Smad4 is a common mediator, as well.... -
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- Smad1 Expression in Follicular Lymphoma
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Go JH
- KMID: 2381383
- J Pathol Transl Med.
- 2015 May;49(3):243-248.
- doi: 10.4132/jptm.2015.03.30
BACKGROUND: Follicular lymphomas present with various immunohistologic patterns. The immunohistochemical markers used in the diagnosis of follicular lymphoma show variable degrees of sensitivity and specificity, and thus, additional germinal center... -
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- Low Level Light Therapy Using an 830-nm Light Emitting Diode Promotes Wound Healing via TGF-β/SMAD Pathway Activation
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Kim SK, Soh BW, Kim YC
- KMID: 2379898
- Korean J Dermatol.
- 2017 May;55(4):237-245.
BACKGROUND: The transforming growth factor-β/SMAD (TGF-β/SMAD) pathway plays an important role in tissue repair and collagen synthesis. Low-level light therapy (LLLT) is increasingly used to alleviate pain and inflammation and... -
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- Activin Receptor-Like Kinase 5 Inhibitor Attenuates Fibrosis in Fibroblasts Derived from Peyronie's Plaque
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Jang JH, Ryu JK, Suh JK
- KMID: 1988823
- Korean J Urol.
- 2012 Jan;53(1):44-49.
- doi: 10.4111/kju.2012.53.1.44
PURPOSE: Transforming growth factor-beta1 (TGF-beta1) is the key fibrogenic cytokine associated with Peyronie's disease (PD). The aim of this study was to determine the antifibrotic effect of 3-((5-(6-Methylpyridin-2-yl)-4-(quinoxalin-6-yl)-1H-imidazol-2-yl) methyl)benzamide (IN-1130),... -
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- Fucoidan promotes osteoblast differentiation via JNK- and ERK-dependent BMP2-Smad 1/5/8 signaling in human mesenchymal stem cells
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Kim BS, Kang HJ, Park JY, Lee J
- KMID: 2155393
- Exp Mol Med.
- 2015 Jan;47(1):e128.
- doi: 10.1038/emm.2014.95
Fucoidan has attracted attention as a potential drug because of its biological activities, which include osteogenesis. However, the molecular mechanisms involved in the osteogenic activity of fucoidan in human alveolar... -
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- Transcriptional Regulation of the Xbr-1a/Xvent-2 Gene by BMP-4 Signaling during Xenopus Embryonic Development
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Kim JB, Lee HS, Roh DH, Hwang YS, Xu RH, Kung HF, Bae YC, Park MJ
- KMID: 2224548
- Korean J Anat.
- 2000 Oct;33(5):595-608.
BMP-4 signaling is mediated through Smad proteins which may translocate to the nucleus to activate transcription. Little is known about how BMP-4 signaling regulates the transcription of its target genes,... -
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- Altered Gene Expression Profile After Exposure to Transforming Growth Factor beta1 in the 253J Human Bladder Cancer Cell Line
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Lee C, Lee SH, Kim DS, Jeon YS, Lee NK, Lee SE
- KMID: 1794590
- Korean J Urol.
- 2014 Aug;55(8):542-550.
- doi: 10.4111/kju.2014.55.8.542
PURPOSE: Transforming growth factor beta1 (TGF-beta1) inhibits the growth of bladder cancer cells and this effect is prominent and constant in 253J bladder cancer cells. We performed a microarray analysis... -
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- The Effects of Retinoic Acid and MAPK Inhibitors on Phosphorylation of Smad2/3 Induced by Transforming Growth Factor β1
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Lee SH, Shin JH, Shin MH, Kim YS, Chung KS, Song JH, Kim SY, Kim EY, Jung JY, Kang YA, Chang J, Park MS
- KMID: 2441729
- Tuberc Respir Dis.
- 2019 Jan;82(1):42-52.
- doi: 10.4046/trd.2017.0111
BACKGROUND: Transforming growth factor β (TGF-β), retinoic acid (RA), p38 mitogen-activated protein kinase (MAPK), and MEK signaling play critical roles in cell differentiation, proliferation, and apoptosis. We investigated the effect... -
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- Modulation of cartilage differentiation by melanoma inhibiting activity/cartilage-derived retinoic acid-sensitive protein (MIA/CD-RAP)
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Schubert T, Schlegel J, Schmid R, Opolka A, Grassel S, Humphries , Bosserhoff AK
- KMID: 946649
- Exp Mol Med.
- 2010 Mar;42(3):166-174.
- doi: 10.3858/emm.2010.42.3.017
Melanoma inhibiting activity/cartilage-derived retinoic acid-sensitive protein (MIA/CD-RAP) is a small soluble protein secreted from malignant melanoma cells and from chondrocytes. Recently, we revealed that MIA/CD-RAP can modulate bone morphogenetic protein... -
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- Role of TGF-beta signaling and Ski/SnoN mRNA expression in cervical carcinomas
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Jung JD, Lee SK, Kim SB, Chi SG
- KMID: 2262550
- Korean J Obstet Gynecol.
- 2002 Jan;45(1):60-70.
OBJECTIVE: TGF-beta signaling is dependent on the heterodimerization of the type II TGF-beta receptor (TbetaR-II) with the type I TGF-beta receptor (TbetaR-I). which mediate intracellular signals through Smad proteins. Whereas... -
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- Melanin extract from Gallus gallus domesticus promotes proliferation and differentiation of osteoblastic MG-63 cells via bone morphogenetic protein-2 signaling
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Yoo HS, Chung KH, Lee KJ, Kim DH, An JH
- KMID: 2407766
- Nutr Res Pract.
- 2017 Jun;11(3):190-197.
- doi: 10.4162/nrp.2017.11.3.190
BACKGROUND/OBJECTIVES: Gallus gallus domesticus (GD) is a natural mutant breed of chicken in Korea with an atypical characterization of melanin in its tissue. This study investigated the effects of melanin... -
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