- Simvastatin Induces Apoptosis and Suppresses Insulin-Like Growth Factor 1 Receptor in Bile Duct Cancer Cells
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Lee J, Hong EM, Jang JA, Park SW, Koh DH, Choi MH, Jang HJ, Kae SH
- KMID: 2363978
- Gut Liver.
- 2016 Mar;10(2):310-317.
- doi: 10.5009/gnl15195
BACKGROUND/AIMS: Statins act as antineoplastic agents through the inhibition of cell proliferation. This study sought to demonstrate the effects of statins on extrahepatic bile duct cancer cell apoptosis and to... -
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- Simvastatin inhibits sphingosylphosphorylcholine-induced differentiation of human mesenchymal stem cells into smooth muscle cells
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Kim KH, Kim YM, Lee MJ, Ko HC, Kim MB, Kim JH
- KMID: 1120134
- Exp Mol Med.
- 2012 Feb;44(2):159-166.
- doi: 10.3858/emm.2012.44.2.011
Sphingosylphosphorylcholine (SPC) induces differentiation of human adipose tissue-derived mesenchymal stem cells (hASCs) into smooth muscle-like cells expressing alpha-smooth muscle actin (alpha-SMA) via transforming growth factor-beta1/Smad2- and RhoA/Rho kinase-dependent mechanisms. 3-Hydroxy-3-methylglutaryl-coenzyme... -
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- Stereological Comparison of the Effects of Pentoxifylline, Captopril, Simvastatin, and Tamoxifen on Kidney and Bladder Structure After Partial Urethral Obstruction in Rats
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Shirazi M, Soltani MR, Jahanabadi Z, Abdollahifar MA, Tanideh N, Noorafshan A
- KMID: 2069919
- Korean J Urol.
- 2014 Nov;55(11):756-763.
- doi: 10.4111/kju.2014.55.11.756
PURPOSE: Limited studies have shown antifibrotic effects of pentoxifylline, captopril, simvastatin, and tamoxifen. No comparisons are available of the effects of these drugs on prevention of renal and bladder changes... -
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- Simvastatin inhibits osteoclast differentiation by scavenging reactive oxygen species
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Moon HJ, Kim SE, Yun YP, Hwang YS, Bang JB, Park JH, Kwon IK
- KMID: 1025163
- Exp Mol Med.
- 2011 Nov;43(11):605-612.
- doi: 10.3858/emm.2011.43.11.067
Osteoclasts, together with osteoblasts, control the amount of bone tissue and regulate bone remodeling. Osteoclast differentiation is an important factor related to the pathogenesis of bone-loss related diseases. Reactive oxygen... -
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- The Effect of Simvastatin on the Proliferation and Differentiation of Human Bone Marrow Stromal Cells
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Baek KH, Lee WY, Oh KW, Tae HJ, Lee JM, Lee EJ, Han JH, Kang MI, Cha BY, Lee KW, Son HY, Kang SK
- KMID: 1778503
- J Korean Med Sci.
- 2005 Jun;20(3):438-444.
- doi: 10.3346/jkms.2005.20.3.438
Statins have been postulated to affect the bone metabolism. Recent experimental and epidemiologic studies have suggested that statins may also have bone protective effects. This study assessed the effects of... -
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- Simvastatin Reduces Capsular Fibrosis around Silicone Implants
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Chung KJ, Park KR, Lee JH, Kim TG, Kim YH
- KMID: 2373756
- J Korean Med Sci.
- 2016 Aug;31(8):1273-1278.
- doi: 10.3346/jkms.2016.31.8.1273
Capsular fibrosis and contracture occurs in most breast reconstruction patients who undergo radiotherapy, and there is no definitive solution for its prevention. Simvastatin was effective at reducing fibrosis in various... -
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- Simvastatin inhibits induction of matrix metalloproteinase-9 in rat alveolar macrophages exposed to cigarette smoke extract
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Kim SE, Thuy TT, Lee JH, Ro JY, Bae YA, Kong Y, Ahn JY, Lee DS, Oh YM, Lee SD, Lee YS
- KMID: 1088603
- Exp Mol Med.
- 2009 Apr;41(4):277-287.
- doi: 10.3858/emm.2009.41.4.031
Matrix metalloproteinase-9 (MMP-9) may play an important role in emphysematous change in chronic obstructive pulmonary disease (COPD), one of the leading causes of mortality and morbidity worldwide. We previously reported... -
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- Effect of Statin on the Reference Segments after Bare-Metal Stent Implantation
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Kim BK, Hong MK
- KMID: 964714
- Korean J Intern Med.
- 2010 Dec;25(4):353-355.
- doi: 10.3904/kjim.2010.25.4.353
No abstract available. -
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- Potential role of HMG CoA reductase inhibitor on oxidative stress induced by advanced glycation endproducts in vascular smooth muscle cells of diabetic vasculopathy
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Yoon SJ, Yoon YW, Lee BK, Kwon HM, Hwang KC, Kim M, Chang W, Hong BK, Lee YH, Park SJ, Min PK, Rim SJ
- KMID: 1122281
- Exp Mol Med.
- 2009 Nov;41(11):802-811.
- doi: 10.3858/emm.2009.41.11.086
Advanced glycation endproducts (AGEs)-induced vascular smooth muscle cell (VSMCs) proliferation and formation of reactive oxygen species (ROS) are emerging as one of the important mechanisms of diabetic vasculopathy but little... -
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