- Inhibition of Wnt Signaling by Silymarin in Human Colorectal Cancer Cells
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Eo HJ, Park GH, Jeong JB
- KMID: 2351686
- Biomol Ther.
- 2016 Jul;24(4):380-386.
- doi: 10.4062/biomolther.2015.154
Silymarin from milk thistle (Silybum marianum) has been reported to show an anti-cancer activity. In previous study, we reported that silymarin induces cyclin D1 proteasomal degradation through NF-κB-mediated threonine-286 phosphorylation.... -
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- Silymarin Inhibits Cytokine-Stimulated Pancreatic Beta Cells by Blocking the ERK1/2 Pathway
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Kim EJ, Kim J, Lee MY, Sudhanva M, Devakumar , Jeon YJ
- KMID: 2170620
- Biomol Ther.
- 2014 Jul;22(4):282-287.
We show that silymarin, a polyphenolic flavonoid isolated from milk thistle (Silybum marianum), inhibits cytokine mixture (CM: TNF-alpha, IFN-gamma, and IL-1beta)-induced production of nitric oxide (NO) in the pancreatic beta... -
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- Comparison of Silymarin, Penicillin, N-acetylcysteine in Patient with Amatoxin Poisoning: A Systematic Review
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Choi MW, Ko DR, Kong T, Choa MH, You JS, Chung SP
- KMID: 2436262
- J Korean Soc Clin Toxicol.
- 2018 Jun;16(1):33-41.
- doi: 10.22537/jksct.2018.16.1.33
PURPOSE: This study was conducted to evaluate the clinical efficacy of pharmacologic treatment of amatoxin poisoning patients. METHODS: Literature was accessed through PubMed, EMBASE, Cochrane library, KoreaMed, KISS and KMBASE. Studies... -
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- Silymarin Inhibits Morphological Changes in LPS-Stimulated Macrophages by Blocking NF-kappaB Pathway
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Kim EJ, Lee MY, Jeon YJ
- KMID: 1791421
- Korean J Physiol Pharmacol.
- 2015 May;19(3):211-218.
- doi: 10.4196/kjpp.2015.19.3.211
The present study showed that silymarin, a polyphenolic flavonoid isolated from milk thistle (Silybum marianum), inhibited lipopolysaccharide (LPS)-induced morphological changes in the mouse RAW264.7 macrophage cell line. We also showed... -
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- Effect of Prophylactic Use of Silymarin on Anti-tuberculosis Drugs Induced Hepatotoxicity
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Heo E, Kim DK, Oh SH, Lee JK, Park JH, Chung HS
- KMID: 2385041
- Tuberc Respir Dis.
- 2017 Jul;80(3):265-269.
- doi: 10.4046/trd.2017.80.3.265
BACKGROUND: The first line of anti-tuberculosis (TB) drugs are the most effective standard of drugs for TB. However, the use of these drugs is associated with hepatotoxicity. Silymarin has protective... -
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- Determination of Silybin B in the Different Parts of Silybum marianum using HPLC-UV
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Rodriguez , Quilantang NG, Lee JS, Lee JM, Kim HY, Shim JS, Lee S
- KMID: 2416066
- Nat Prod Sci.
- 2018 Jun;24(2):82-87.
- doi: 10.20307/nps.2018.24.2.82
Silymarin is the standardized extract from Silybum marianum which consists mainly of flavonoids and polyphenols. It is highly regarded for its hepatoprotective ability. Silybin B is a flavonolignan and one... -
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- Protective effects of silymarin on fumonisin B1-induced hepatotoxicity in mice
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Sozmen M, Devrim AK, Tunca R, Bayezit M, Dag S, Essiz D
- KMID: 1737610
- J Vet Sci.
- 2014 Mar;15(1):51-60.
- doi: 10.4142/jvs.2014.15.1.51
The present study was conducted to investigate the effect of silymarin on experimental liver toxication induced by Fumonisin B1 (FB1) in BALB/c mice. The mice were divided into six groups... -
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- Inhibition of ERK1/2 by silymarin in mouse mesangial cells
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Youn CK, Cho SI, Lee MY, Jeon YJ, Lee SK
- KMID: 2371075
- Korean J Physiol Pharmacol.
- 2017 Jan;21(1):117-124.
- doi: 10.4196/kjpp.2017.21.1.117
The present study aimed to show that pro-inflammatory cytokines [tumor necrosis factor (TNF)-α, interferon (IFN)-γ, and interleukin (IL)-1β] synergistically induce the production of nitric oxide (NO) production in mouse mesangial... -
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- Silymarin's Protective Effects and Possible Mechanisms on Alcoholic Fatty Liver for Rats
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Zhang W, Hong R, Tian T
- KMID: 2170671
- Biomol Ther.
- 2013 Jul;21(4):264-269.
Silymarin has been introduced fairly recently as a hepatoprotective agent. But its mechanisms of action still have not been well established. The aim of this study was to make alcoholic... -
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- A Case of Spontaneous Regressio and Recurrence of Hepatocellular Carcinoma
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Lee SO, Lim CS, Lee ST, Kim DG, Ahn DS
- KMID: 2084930
- Korean J Gastroenterol.
- 1999 Apr;33(4):580-586.
hepatocellular carcinoma. A 62-year-old man was diagnosed as a hepatocellular carcinoma by abdo minal computerized tomography (CT) and the elevated serum alpha-fetoprotein (alpha FP) concentration. He refused further evaluation involving... -
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- RNA-Seq De Novo Assembly and Differential Transcriptome Analysis of Korean Medicinal Herb Cirsium japonicum var. spinossimum
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Roy NS, Kim JA, Choi AY, Ban YW, Park NI, Park KC, Yang HS, Choi IY, Kim S
- KMID: 2439224
- Genomics Inform.
- 2018 Dec;16(4):e34.
- doi: 10.5808/GI.2018.16.4.e34
Cirsium japonicum belongs to the Asteraceae or Compositae family and is a medicinal plant in Asia that has a variety of effects, including tumour inhibition, improved immunity with flavones, and... -
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- Effects of White Radish (Raphanus sativus) Enzyme Extract on Hepatotoxicity
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Lee SW, Yang KM, Kim JK, Nam BH, Lee CM, Jeong MH, Seo SY, Kim GY, Jo WS
- KMID: 2317803
- Toxicol Res.
- 2012 Sep;28(3):165-172.
Raphanus sativus (Cruciferaceae), commonly known as radish is widely available throughout the world. From antiquity it has been used in folk medicine as a natural drug against many toxicants. The... -
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- Anti-fibrotic effects of Orostachys japonicus A. Berger (Crassulaceae) on hepatic stellate cells and thioacetamide-induced fibrosis in rats
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Koppula S, Yum MJ, Kim JS, Shin GM, Chae YJ, Yoon T, Chun CS, Lee JD, Song M
- KMID: 2395301
- Nutr Res Pract.
- 2017 Dec;11(6):470-478.
- doi: 10.4162/nrp.2017.11.6.470
BACKGROUND/OBJECTIVE: Orostachys japonicus A. Berger (Crassulaceae) has been used in traditional herbal medicines in Korea and other Asian countries to treat various diseases, including liver disorders. In the present study,... -
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- Anti-oxidant activities of kiwi fruit extract on carbon tetrachloride-induced liver injury in mice
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Kang W, Yang H, Hong HJ, Han CH, Lee YJ
- KMID: 1431989
- Korean J Vet Res.
- 2012 Dec;52(4):275-280.
The kiwi (Actinidia deliciosa) is well known to contain anti-oxidants. In this study, we investigated the anti-oxidant effects of kiwi extract on carbon tetrachloride (CCl4) induced liver injury in BALB/c... -
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- In Silico Docking to Explicate Interface between Plant-Originated Inhibitors and E6 Oncogenic Protein of Highly Threatening Human Papillomavirus 18
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Kumar S, Jena L, Sahoo M, Kakde M, Daf S, Varma AK
- KMID: 2009148
- Genomics Inform.
- 2015 Jun;13(2):60-67.
- doi: 10.5808/GI.2015.13.2.60
The leading cause of cancer mortality globally amongst the women is due to human papillomavirus (HPV) infection. There is need to explore anti-cancerous drugs against this life-threatening infection. Traditionally, different... -
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- Sparassis crispa Attenuates Carbon Tetrachloride-Induced Hepatic Injury in Rats
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Yan GH, Choi YH
- KMID: 2283727
- Korean J Phys Anthropol.
- 2014 Sep;27(3):113-122.
- doi: 10.11637/kjpa.2014.27.3.113
Sparassis crispa is an edible mushroom with various medicinal properties. Here we demonstrate the effect of Sparassis crispa on carbon tetrachloride (CCl4)-induced hepatotoxicity and the underlying mechanism. To evaluate the hepatoprotective... -
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- Hepatoprotective effect of sodium hydrosulfide on hepatic encephalopathy in rats
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Kwon KW, Nam Y, Choi WS, Kim TW, Kim GM, Sohn UD
- KMID: 2450493
- Korean J Physiol Pharmacol.
- 2019 Jul;23(4):263-270.
- doi: 10.4196/kjpp.2019.23.4.263
Hydrogen sulfide is well-known to exhibit anti-inflammatory and cytoprotective activities, and also has protective effects in the liver. This study aimed to examine the protective effect of hydrogen sulfide in... -
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- Pretreatment of Albino Rats with Methanolic Fruit Extract of Randia Dumetorum (L.) Protects against Alcohol Induced Liver Damage
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Noorani AA, Kale MK
- KMID: 2071758
- Korean J Physiol Pharmacol.
- 2012 Apr;16(2):125-130.
- doi: 10.4196/kjpp.2012.16.2.125
Alcohol abuse and its medical and social consequences are a major health problem in many areas of the world. The present study was conducted to evaluate the protective effect of... -
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- Beneficial Effects of Silibinin Against Kainic Acid-induced Neurotoxicity in the Hippocampus in vivo
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Kim S, Jung UJ, Oh YS, Jeon MT, Kim HJ, Shin WH, Hong J, Kim SR
- KMID: 2398431
- Exp Neurobiol.
- 2017 Oct;26(5):266-277.
- doi: 10.5607/en.2017.26.5.266
Silibinin, an active constituent of silymarin extracted from milk thistle, has been previously reported to confer protection to the adult brain against neurodegeneration. However, its effects against epileptic seizures have... -
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- Hepaprotective Effect of Standardized Ecklonia stolonifera Formulation on CClâ‚„-Induced Liver Injury in Sprague-Dawley Rats
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Byun JH, Kim J, Choung SY
- KMID: 2429062
- Biomol Ther.
- 2018 Mar;26(2):218-223.
- doi: 10.4062/biomolther.2017.199
The liver is an essential organ for the detoxification of exogenous xenobiotics, drugs and toxic substances. The incidence rate of non-alcoholic liver injury increases due to dietary habit change and... -
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