- Asp 280 residue is important in the activity of the Escherichia coli leader peptidase
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Sung MS, Park KS
- KMID: 1029933
- Exp Mol Med.
- 1999 Jun;31(2):64-69.
Leader peptidase is a novel serine protease in Escherichia coli, which catalyzes the cleavage of amino-terminal signal sequences from exported proteins. It is an integral membrane protein containing two transmembrane segments with... -
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- Intraocular infusate with hemocoagulase for the control of bleeding during vitreous surgery
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Lee HS, Kim SH, Kim IT
- KMID: 1735035
- Korean J Ophthalmol.
- 1989 Jun;3(1):6-10.
- doi: 10.3341/kjo.1989.3.1.6
The effects of hemocoagulase in injectable form (hemocoagulating enzymatic fraction of South American snake Bothrops jararaca venom provided by Ravizza) on the control of intraocular bleeding during vitreous surgery were... -
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- Cloning of a Family of Serine Protease Genes Expressed in German Cockroach(Blattella germanica) and Possibility as Allergens
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Lee WY, Kim HB, Park JR, Park SH, Park KW, Ock MS, Yu TH
- KMID: 2276895
- Korean J Otorhinolaryngol-Head Neck Surg.
- 2008 Jun;51(6):528-534.
BACKGROUND AND OBJECTIVES: The serine protease allergens have been known as one of the most important inhalent allergens of insects as well as house dust mites. There is no known... -
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- A molecular model of a point mutation (Val297Met) in the serine protease domain of protein C
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Song KS, Park YS, Choi JR, Kim HK, Park Q
- KMID: 755027
- Exp Mol Med.
- 1999 Mar;31(1):47-51.
A heterozygous GTG to ATG (Val297Met) mutation was detected in a patient with inherited protein C deficiency and deep vein thrombosis. Cosegregation of the mutation with protein C deficiency was observed through... -
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- The homotrimeric structure of HtrA2 is indispensable for executing its serine protease activity
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Nam MK, Seong YM, Park HJ, Choi JY, Kang S, Rhim H
- KMID: 1105275
- Exp Mol Med.
- 2006 Feb;38(1):36-43.
Serine protease activity of high temperature requrement 2 (HtrA2) is essential for promoting cell death, as well as for protecting against cellular stresses. An X-ray crystallographic study described the formation... -
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- Purification and characterization of a 33 kDa serine protease from Acanthamoeba lugdunensis KA/E2 isolated from a Korean keratitis patient
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Kim HK, Ha YR, Yu HS, Kong HH, Chung DI
- KMID: 662758
- Korean J Parasitol.
- 2003 Dec;41(4):189-196.
- doi: 10.3347/kjp.2003.41.4.189
In order to evaluate the possible roles of secretory proteases in the pathogenesis of amoebic keratitis, we purified and characterized a serine protease secreted by Acanthamoeba lugdunensis KA/E2, isolated from... -
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- Intactness of zona pellucida does not affect the secretion of a trypsin-like protease from mouse blastocyst
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Hwang SS, Lee EY, Chung YC, Yoon BK, Lee JH, Choi DS
- KMID: 965874
- J Korean Med Sci.
- 2000 Oct;15(5):529-532.
- doi: 10.3346/jkms.2000.15.5.529
Assisted hatching (AH), which is known to improve the hatching potential of mammalian embryos, has been used to increase the pregnancy rate in in vitro fertilization cycles. However, the effect... -
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- Upregulation of Prostasin in Nasal Polyps
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Yoo JH, Park SJ, Lee HM, Lee SH, Lee SH, Kim TH
- KMID: 2297579
- J Rhinol.
- 2012 May;19(1):50-54.
OBJECTIVES/HYPOTHESIS: Prostasin is a protease that activates epithelial sodium channels (ENaC), which mediate Na+ absorption across epithelial surfaces. Human nasal polyps absorb more ENaC-mediated Na+ than normal mucosa. We investigated... -
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- Comparison of specific activity and cytopathic effects of purified 33 kDa serine proteinase from Acanthamoeba strains with different degree of virulence
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Kim WT, Kong HH, Ha YR, Hong YC, Jeong HJ, Yu HS, Chung DI
- KMID: 1088764
- Korean J Parasitol.
- 2006 Dec;44(4):321-330.
- doi: 10.3347/kjp.2006.44.4.321
The pathogenic mechanism of granulomatous amebic encephalitis (GAE) and amebic keratitis (AK) by Acanthamoeba has yet to be clarified. Protease has been recognized to play an important role in the... -
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- Granzyme B immunoreactivity in T/natural killer cell lymphomas
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Cho MS, Lee MK, Yang WI, Yoon JH
- KMID: 699963
- Yonsei Med J.
- 1997 Oct;38(5):285-293.
- doi: 10.3349/ymj.1997.38.5.285
Granzyme B is one of the serine proteases expressed in natural killer (NK) cells and activated cytotoxic T-lymphocytes. To evaluate the usefulness of granzyme B immunoreactivity in the diagnosis of... -
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- In silico Screening of Chemical Libraries to Develop Inhibitors That Hamper the Interaction of PCSK9 with the LDL Receptor
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Min DK, Lee HS, Lee N, Lee CJ, Song HJ, Yang GE, Yoon D, Park SW
- KMID: 2163616
- Yonsei Med J.
- 2015 Sep;56(5):1251-1257.
- doi: 10.3349/ymj.2015.56.5.1251
PURPOSE: Proprotein convertase subtilisin/kexin type 9 (PCSK9) binds to the low density lipoprotein receptor (LDLR) and promotes degradation of the LDLR. Inhibition of PCSK9 either by reducing its expression or... -
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- Pharmacogenetic Influence of LOC387715/HTRA1 on the Efficacy of Bevacizumab Treatment for Age-Related Macular Degeneration in a Korean Population
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Kang HK, Yoon MH, Lee DH, Chin HS
- KMID: 1499678
- Korean J Ophthalmol.
- 2012 Dec;26(6):414-422.
- doi: 10.3341/kjo.2012.26.6.414
PURPOSE: The purpose of this study was to determine the pharmacogenetic effects of complement factor H (CFH) Y402H, LOC387715 and high-temperature requirement factor A1 (HTRA1) genotypes on the treatment of... -
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- IgG antibody responses in early experimental sparganosis and IgG subclass responses in human sparganosis
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Chung YB, Kong Y, Yang HJ, Cho SY
- KMID: 1720316
- Korean J Parasitol.
- 2000 Sep;38(3):145-150.
- doi: 10.3347/kjp.2000.38.3.145
Antigenic components in the crude extracts of Spirometra mansoni plerocercoid were analyzed in early experimental infections and in IgG subclass observed in clinical sparganosis. By IgG immunoblot, sera obtained serially... -
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- Granzyme B and TIA-1 Expression in Chronic and Acute on Chronic Renal Allograft Rejection
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Hong SW, Jeong HJ, Kim SI, Moon JI, Kim YS, Park K
- KMID: 720623
- Yonsei Med J.
- 2001 Jun;42(3):285-290.
- doi: 10.3349/ymj.2001.42.3.285
Although active inflammation may be deleterious and indicate immunologic activation in chronically rejected grafts, the underlying mechanism of tissue destruction has been little studied. Twenty-four cases of chronic rejection (CR)... -
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- Molecular Analysis of Two Cases of Severe Congenital Neutropenia
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Park J, Kim M, Lim J, Kim Y, Cho B, Park YJ, Han K
- KMID: 1096794
- Korean J Lab Med.
- 2010 Apr;30(2):111-116.
- doi: 10.3343/kjlm.2010.30.2.111
Severe congenital neutropenia is a rare hematological disease characterized by a selective decrease in circulating neutrophils, maturation arrest of granulocytic precursors at the promyelocyte stage, and recurrence of infections. A... -
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- Epstein-Barr Virus-Associated Peripheral T-Cell Lymphoma involving Spleen in a Renal Transplant Patient
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Lee HK, Kim HJ, Lee EH, Kim SY, Park TI, Kang CS, Yang WI
- KMID: 2157634
- J Korean Med Sci.
- 2003 Apr;18(2):272-276.
- doi: 10.3346/jkms.2003.18.2.272
The incidence of posttransplantation lymphoproliferative disorders (PTLDs) has increased in recent years. Although rare, various types of T-cell lymphoma have been reported and their association with Epstein-Barr virus (EBV) has... -
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- Eosinophil Inflammation of Nasal Polyp Tissue: Relationships with Matrix Metalloproteinases, Tissue Inhibitor of Metalloproteinase-1, and Transforming Growth Factor-beta1
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Park HS, Kim SS, Kim HA, Suh YJ, Lee SK, Nahm DH, Lee YM
- KMID: 1099801
- J Korean Med Sci.
- 2003 Feb;18(1):97-102.
- doi: 10.3346/jkms.2003.18.1.97
Eosinophil and mast cell infiltrations are consistent findings in nasal polyp tissue. Previous studies have shown that matrix metalloproteinases (MMPs) may be involved in eosinophil infiltration in airway mucosa of... -
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- Mucosal mast cell-derived chondroitin sulphate levels in and worm expulsion from FcRgamma-knockout mice following oral challenge with Strongyloides venezuelensis
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Onah DN, Nawa Y
- KMID: 1099835
- J Vet Sci.
- 2004 Sep;5(3):221-226.
Mucosal mast cell-derived chondroitin sulphates (sulphated proteoglycans) were assayed in gut washings and homogenate of FcRgamma-knockout (KO) and wild-type (WT) C57BL/6 mice challenged with Strongyloides venezuelensis in order to assess... -
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- Frequent Epigenetic Inactivation of XAF1 by Promotor Hypermethylation in Human Colon Cancers
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Jang JY, Kim HJ, Chi SG, Lee KY, Nam KD, Kim NH, Lee SK, Joo KR, Dong SH, Kim BH, Chang YW, Lee JI, Chang R
- KMID: 772766
- Korean J Gastroenterol.
- 2005 Apr;45(4):285-293.
BACKGROUND/AIMS: X-linked inhibitor of apoptosis (XIAP) is the most potent member of the IAP family that exerts antiapoptotic effects. Recently, XIAP-associated factor 1 (XAF1) and two mitochondrial proteins, Smac/DIABLO... -
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