- Effects of Dietary Folate Supplementation on the Homocystine Diet-Induced Hyperhomocysteinemia and Hepatic S-Adenosylmethionine Metabolism in Rats
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Kim JM, Lee HY, Chang N
- KMID: 1618393
- Korean J Nutr.
- 2003 Oct;36(8):811-818.
We investigated the effects of dietary folate supplementation on plasma homocysteine, vitamin B12 and hepatic levels of S-adenosylmethionine (SAM) and S-adenosylhomocysteine (SAH) in diet-induced hyperhomocysteinemic rats. All animals were fed... -
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- Comparative Analysis of the Three Classes of Archaeal and Bacterial Ribonucleotide Reductase from Evolutionary Perspective
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Pangare MG, Chandra SB
- KMID: 1806199
- Genomics Inform.
- 2010 Dec;8(4):170-176.
The Ribonucleotide reductases (RNR) are essential enzymes that catalyze the conversion of nucleotides to deoxynucleotides in DNA replication and repair in all living organisms. The RNRs operate by a free... -
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- Protective Effects of S-Adenosylmethionine and Its Combinations With Taurine and/or Betaine Against Lipopolysaccharide or Polyinosinic-polycytidylic Acid-induced Acute Hepatotoxicity
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Lee SY, Ko KS
- KMID: 2367573
- J Cancer Prev.
- 2016 Sep;21(3):152-163.
- doi: 10.15430/JCP.2016.21.3.152
BACKGROUND: Several mechanisms for the pathogenesis of many liver diseases are related with oxidative stress, endotoxins, and infections by many microorganisms. These can lead to chronic hepatitis, cirrhosis, and even... -
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- Effects of S-Adenosylmethionine and Its Combinations With Taurine and/or Betaine on Glutathione Homeostasis in Ethanol-induced Acute Hepatotoxicity
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Lee SY, Ko KS
- KMID: 2367574
- J Cancer Prev.
- 2016 Sep;21(3):164-172.
- doi: 10.15430/JCP.2016.21.3.164
BACKGROUND: Exposure to ethanol abuse and severe oxidative stress are risk factors for hepatocarcinoma. The aim of this study was to evaluate the effects of S-adenosylmethionine (SAMe) and its combinations... -
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- Folate Augmentation Therapy in Depression
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Yoon CH
- KMID: 1554206
- Korean J Psychopharmacol.
- 1999 Oct;10(2):185-190.
OBJECTIVE: It has been suggested that folate deficiency can cause psychiatric disturbances of depressive nature and the possible pathogenetic mediating mechanism is the deflect in methylation processes of S-adenosylmethionine in... -
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- Effects of dietary supplementation of high-dose folic acid on biomarkers of methylating reaction in vitamin B12-deficient rats
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Min H
- KMID: 2313387
- Nutr Res Pract.
- 2009 Jun;3(2):122-127.
Folate is generally considered as a safe water-soluble vitamin for supplementation. However, we do not have enough information to confirm the potential effects and safety of folate supplementation and the... -
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- S-adenosylmethionine reduces airway inflammation and fibrosis in a murine model of chronic severe asthma via suppression of oxidative stress
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Yoon SY, Hong GH, Kwon HS, Park S, Park SY, Shin B, Kim TB, Moon HB, Cho YS
- KMID: 2361523
- Exp Mol Med.
- 2016 Jun;48(6):e236.
- doi: 10.1038/emm.2016.35
Increased oxidative stress has an important role in asthmatic airway inflammation and remodeling. A potent methyl donor, S-adenosylmethionine (SAMe), is known to protect against tissue injury and fibrosis through modulation... -
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- Genomic DNA Methylation Status and Plasma Homocysteine in Choline- and Folate-Deficient Rats
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Mun JA, Min H
- KMID: 2259850
- Korean J Nutr.
- 2007 Jan;40(1):14-23.
Elevated plasma homocysteine ( Hcy) is a risk factor for cognitive dysfunction and Alzheimer disease, although the mechanism is still unknown. Both folate and betaine, a choline metabolite, play essential... -
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- Molecular and Functional Characterization of Choline Transporter-Like Proteins in Esophageal Cancer Cells and Potential Therapeutic Targets
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Nagashima , Nishiyama , Iwao B, Kawai Y, Ishii C, Yamanaka T, Uchino H, Inazu M
- KMID: 2420391
- Biomol Ther.
- 2018 Jul;26(4):399-408.
- doi: 10.4062/biomolther.2017.113
In this study, we examined the molecular and functional characterization of choline uptake in the human esophageal cancer cells. In addition, we examined the influence of various drugs on the... -
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- A Critical Evaluation of the Correlation Between Biomarkers of Folate and Vitamin B12 in Nutritional Homocysteinemia
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Min H, Kim M
- KMID: 2267324
- Korean J Nutr.
- 2009 Jul;42(5):423-433.
- doi: 10.4163/kjn.2009.42.5.423
Folate and vitamin B12 are essential cofactors for homocysteine (Hcy) metabolism. Homocysteinemia has been related with cardiovascular and neurodegenerative disease. We examined the effect of folate and/or vitamin B12 deficiency... -
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- Effects of excessive dietary methionine on oxidative stress and dyslipidemia in chronic ethanol-treated rats
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Kim SY, Kim H, Min H
- KMID: 2313822
- Nutr Res Pract.
- 2015 Apr;9(2):144-149.
- doi: 10.4162/nrp.2015.9.2.144
BACKGROUND/OBJECTIVE: The aim of this study was to examine the effect of high dietary methionine (Met) consumption on plasma and hepatic oxidative stress and dyslipidemia in chronic ethanol fed rats. MATERIALS/METHODS:... -
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- Effects of vitamin C and E supplementation on oxidative stress and liver toxicity in rats fed a low-fat ethanol diet
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Lee SJ, Kim SY, Min H
- KMID: 2391962
- Nutr Res Pract.
- 2013 Apr;7(2):109-114.
We compared the preventive capacity of high intakes of vitamin C (VC) and vitamin E (VE) on oxidative stress and liver toxicity in rats fed a low-fat ethanol diet. Thirty-two... -
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- Age-Related Changes in Sulfur Amino Acid Metabolism in Male C57BL/6 Mice
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Jeon JS, Oh JJ, Kwak HC, Yun HY, Kim HC, Kim YM, Oh SJ, Kim SK
- KMID: 2429056
- Biomol Ther.
- 2018 Mar;26(2):167-174.
- doi: 10.4062/biomolther.2017.054
Alterations in sulfur amino acid metabolism are associated with an increased risk of a number of common late-life diseases, which raises the possibility that metabolism of sulfur amino acids may... -
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- Protein methylation in cellular proliferation and differentiation: Non-histone nuclear methyl acceptor protein(s) during 3'-methyl-4-dimethylaminoazobenzeneinduced hepatocarcinogenesis
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Paik MK, Han YJ, Hong JH, Kim JS, Suh KS, Yoon SJ
- KMID: 2128624
- Exp Mol Med.
- 1997 Mar;29(1):35-43.
An accelerating effect of methyl-deficient diet (MDD) on hepatocarcinogenesis and methylation pattern of nuclear protein(s) by S-adenosylmethionine: protein arginine N-methyltransferase (protein methylase I, PM-I) have been studied with 3'-methyl-4-dimethyl- aminoazobenzene(MeDAB)-treated... -
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- Genetic Mutation of 5, 10-Methylenetetrahydrofolate Reductase in the Brain Neoplasms
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Ahn JY, Kim NK, Han JH, Kim JK, Joo JY, Lee KS
- KMID: 2044524
- J Korean Neurosurg Soc.
- 2002 Sep;32(3):183-188.
OBJECTIVE: Recent epidermiologic studies suggested that alterations in folate metabolism as a result of polymorphism in the enzyme 5,10-methylenetetrahydrofolate reductase(MTHFR) have been frequently associated with neural tube defects, vascular disease,... -
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- Mercury Promotes Catecholamines Which Potentiate Mercurial Autoimmunity and Vasodilation: Implications for Inositol 1,4,5-Triphosphate 3-Kinase C Susceptibility in Kawasaki Syndrome
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Yeter D, Deth R, Kuo HC
- KMID: 2224813
- Korean Circ J.
- 2013 Sep;43(9):581-591.
- doi: 10.4070/kcj.2013.43.9.581
Previously, we reviewed biological evidence that mercury could induce autoimmunity and coronary arterial wall relaxation as observed in Kawasaki syndrome (KS) through its effects on calcium signaling, and that inositol... -
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