- Behavioral Testing for Therapeutic Outcome Measurements in an Animal Model of Huntington's Disease
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Cho SR, Park ES, Kim HO, Kim DG, Park CI
- KMID: 2394172
- J Korean Acad Rehabil Med.
- 2007 Oct;31(5):503-511.
OBJECTIVE: To investigate which outcome measurements are useful for detecting functional changes after therapeutic approach to delayed motor impairment in an animal model of Huntington's disease (HD). METHOD: R6/2 transgenic... -
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- Enhancement of Short-Term Memory by Methyl-6-(Phenylethynyl)-Pyridine in the BTBR T+tf/J Mouse Model of Autism Spectrum Disorder
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Yang H, Huh SO, Hong JS
- KMID: 2407111
- Endocrinol Metab.
- 2015 Mar;30(1):98-104.
- doi: 10.3803/EnM.2015.30.1.98
BACKGROUND: Autism spectrum disorder (ASD) encompasses a range of disorders that are characterized by social and communication deficits and repetitive behaviors. This study evaluated the effect of methyl-6-(phenylethynyl)-pyridine (MPEP), an... -
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- Effect on Varying the Impact Velocity in the Controlled Cortical Impact Injury Model: Injury Severity and Impact Velocity
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Ji YC, Min BK, Park SW, Hwang SN, Hong HJ, Suk JS
- KMID: 2067200
- J Korean Neurosurg Soc.
- 2005 Jul;38(1):41-46.
OBJECTIVE: A study of the histopathologic and neurobehavioral correlates of cortical impact injury produced by increasing impact velocity using the controlled cortical impact(CCI) injury model is studied. METHODS: Twenty-four Sprague-Dawley... -
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- Effects Of Glue Sniffing On Weight Increase Or Central Nervous System Of Young Rat
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Kim H, Kim SM, Cho SH
- KMID: 2282632
- Korean J Prev Med.
- 1993 Jun;26(2):222-230.
Industrial glues, known as 'Bonds' in Korea, contain many kinds of organic solvents, and glue sniffing of youths became one of the social problems in Korea. Mixed exposures to solvents... -
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- Establishing Chronic Stroke Rat Models by MCA Occlusion Using Intraluminal Filament
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Lee JH, Moon JY, Park KC, Kim MY
- KMID: 1445607
- Brain Neurorehabil.
- 2011 Mar;4(1):35-43.
- doi: 10.12786/bn.2011.4.1.35
OBJECTIVE: Focal brain ischemia induced in rats by occlusion of middle cerebral artery (MCA) is a widely used paradigm of human brain infarct. The purpose of this study is to... -
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- Analgesic effects of eucalyptus essential oil in mice
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Lee G, Park J, Kim MS, Seol GH, Min SS
- KMID: 2449820
- Korean J Pain.
- 2019 Apr;32(2):79-86.
- doi: 10.3344/kjp.2019.32.2.79
BACKGROUND: The use of aroma oils dates back to at least 3000 B.C., where it was applied to mummify corpses and treat the wounds of soldiers. Since the 1920s, the... -
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- Development of Upgraded Cortical Impact Model (Part II: Functional outcome)
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Choi SM, Suk JS, Min BK, Hwang SN, Kim YB, Kim JH
- KMID: 1955835
- J Korean Neurosurg Soc.
- 2002 Nov;32(5):458-462.
OBJECTIVE: With the technical support from department of mechanical engineering, Korea Advanced Institute of Science and Technology(KAIST), we began to develop a better head trauma model named "Chung-Ang University Hospital... -
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- Oral Administration of Memantine Prolongs Survival in a Transgenic Mouse Model of Amyotrophic Lateral Sclerosis
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Joo IS, Hwang DH, Seok JI, Shin SK, Kim SU
- KMID: 1808551
- J Clin Neurol.
- 2007 Dec;3(4):181-186.
- doi: 10.3988/jcn.2007.3.4.181
BACKGROUND AND PURPOSE: N-methyl-D-aspartate (NMDA)-mediated neurotoxicity and oxidative stress have been implicated in the etiology of amyotrophic lateral sclerosis (ALS). Memantine is a low-affinity, noncompetitive NMDA receptor antagonist that may... -
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- The Effect of Donor-Dependent Administration of Human Umbilical Cord Blood-Derived Mesenchymal Stem Cells following Focal Cerebral Ischemia in Rats
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Park HW, Chang JW, Yang YS, Oh W, Hwang JH, Kim DG, Paek SH
- KMID: 2165571
- Exp Neurobiol.
- 2015 Dec;24(4):358-365.
- doi: 10.5607/en.2015.24.4.358
Stroke is an ischemic disease caused by clotted vessel-induced cell damage. It is characterized by high morbidity and mortality and is typically treated with a tissue plasminogen activator (tPA). However,... -
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- Effects of Oxcarbazepine on Mechanical and Cold Allodynia in a Neuropathic Rat Model
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Jang Y, Moon DE, Yoo JH, Lee HJ, Lee JY, Kwon OK
- KMID: 2239928
- Korean J Anesthesiol.
- 2003 Sep;45(3):385-392.
- doi: 10.4097/kjae.2003.45.3.385
BACKGROUND: It is well known that anticonvusant drugs such as carbamazepine are effective in the management of various neuropathic pain conditions. Oxcarbazepine, a keto analogue of carbamazepine, might also be... -
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- Anti-Allodynic Effects of Levodopa in Neuropathic Rats
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Park HJ, Joo HS, Kim YH, Kwon OK, Lee J, Kim ES, Moon DE
- KMID: 1503893
- Yonsei Med J.
- 2013 Mar;54(2):330-335.
- doi: 10.3349/ymj.2013.54.2.330
PURPOSE: Levodopa is the most effective anti-Parkinsonian agent. It has also been known to exhibit analgesic properties in laboratory and clinical settings. However, studies evaluating its effects on neuropathic pain... -
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- Histopathological and Neurobehavioral Characterization in Adult Mice Exposed to Traumatic Brain Injury
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Oh KY, Choi DW, Jang MS, Lee JH, Kim SC, Park JS, Lee SW, Kim H
- KMID: 2394394
- J Korean Soc Emerg Med.
- 2017 Oct;28(5):457-466.
- doi: 10.0000/jksem.2017.28.5.457
PURPOSE: Traumatic brain injury (TBI) is a significant cause of morbidity and mortality worldwide. Severity of the initial insult is one of the most significant factors affecting outcome following TBI.... -
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- Exploratory, cognitive, and depressive-like behaviors in adult and pediatric mice exposed to controlled cortical impact
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Lee SW, Jang MS, Jeong SH, Kim H
- KMID: 2452985
- Clin Exp Emerg Med.
- 2019 Jun;6(2):125-137.
- doi: 10.15441/ceem.18.019
OBJECTIVE: Sequelae of behavioral impairments associated with human traumatic brain injury (TBI) include neurobehavioral problems. We compared exploratory, cognitive, and depressive-like behaviors in pediatric and adult male mice exposed to... -
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- Magnetic Resonance Spectroscopy Findings According to the Route of Injecting Stem Cells in Experimental Traumatic Brain Injured Rats
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Han EY, Chun MH, Lim DP, Kim ST
- KMID: 2327328
- J Korean Acad Rehabil Med.
- 2011 Apr;35(2):165-173.
OBJECTIVE: To identify the effective injection route for adult human bone marrow stromal cells into traumatic brain injured rats. METHOD: The TBI rats were created by the lateral percussion model (HD1700,... -
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- Neuroprotective Effect of Rapamycin (Autophagy Enhancer) in Transgenic SOD1-G93A Mice of Amyotrophic Lateral Sclerosis
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Ahn SW, Jeon GS, Park KY, Hong YH, Lee KW, Sung JJ
- KMID: 1863274
- Korean J Clin Neurophysiol.
- 2013 Dec;15(2):53-58.
- doi: 10.14253/kjcn.2013.15.2.53
BACKGROUND: The autophagy is the major route for lysosomal degradation of misfolded protein aggregates and oxidative cell components. We hypothesized that rapamycin (autophagy enhancer) would prolong the survival of motor... -
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- Delayed Intraventricular Nogo Receptor Antagonist Promotes Recovery from Stroke by Enhancing Axonal Plasticity
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Kim TW, Lee JK, Joo SP, Kim TS, Kim JH, Kim SH
- KMID: 2067217
- J Korean Neurosurg Soc.
- 2006 Feb;39(2):130-135.
OBJECTIVE: After ischemic stroke, partial recovery of function frequently occurs and may depend on the plasticity of axonal connections. Here, we examine whether blockade of the Nogo/NogoReceptor(NgR) pathway might enhance... -
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- Effect of Epidural Electrical Stimulation and Repetitive Transcranial Magnetic Stimulation in Rats With Diffuse Traumatic Brain Injury
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Yoon YS, Cho KH, Kim ES, Lee MS, Lee KJ
- KMID: 2165645
- Ann Rehabil Med.
- 2015 Jun;39(3):416-424.
- doi: 10.5535/arm.2015.39.3.416
OBJECTIVE: To evaluate the effects of epidural electrical stimulation (EES) and repetitive transcranial magnetic stimulation (rTMS) on motor recovery and brain activity in a rat model of diffuse traumatic brain... -
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- Human Neural Stem Cells Transplantation in Experimental Intracerebral Hemorrhage
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Jeong SW, Chu K, Jung KH, Kim SU, Kim MH, Roh JK
- KMID: 2343042
- J Korean Neurol Assoc.
- 2003 Apr;21(2):183-190.
BACKGROUND: Intracerebral hemorrhage (ICH) is associated with a considerable proportion of stroke and head injuries, but except for supportive care, there is no medical therapy available. Transplantation of human neural... -
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- Neuroprotective effect of caffeic acid phenethyl ester in 3-nitropropionic acid-induced striatal neurotoxicity
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Bak J, Kim HJ, Kim SY, Choi YS
- KMID: 2285600
- Korean J Physiol Pharmacol.
- 2016 May;20(3):279-286.
- doi: 10.4196/kjpp.2016.20.3.279
Caffeic acid phenethyl ester (CAPE), derived from honeybee hives, is a bioactive compound with strong antioxidant activity. This study was designed to test the neuroprotective effect of CAPE in 3-nitropropionic... -
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- Effects of Electric Cortical Stimulation (ECS) and Transcranial Direct Current Stimulation (tDCS) on Rats With a Traumatic Brain Injury
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Yu KP, Yoon YS, Lee JG, Oh JS, Lee JS, Seog T, Lee HY
- KMID: 2420041
- Ann Rehabil Med.
- 2018 Aug;42(4):502-513.
- doi: 10.5535/arm.2018.42.4.502
OBJECTIVE: To evaluate the effects of electric cortical stimulation (ECS) and transcranial direct current stimulation (tDCS) on motor and cognitive function recovery and brain plasticity in focal traumatic brain injury... -
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