- Purification of Opioid Receptor in the Presence of Sodium Ion
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Kil HY
- KMID: 1934791
- Korean J Anesthesiol.
- 1996 Jun;30(6):635-641.
- doi: 10.4097/kjae.1996.30.6.635
BACKGROUND: Purification of opioid receptor is mandatory to improve opiate analgesic medication. Recently, it was reported that sodium ion increased the number of opioid binding sites for opioid antagonist. The... -
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- Differential expression of spinal γ-aminobutyric acid and opioid receptors modulates the analgesic effects of intrathecal curcumin on postoperative/inflammatory pain in rats
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Ju J, Shin JY, Yoon JJ, Yin M, Yoon MH
- KMID: 2436061
- Anesth Pain Med.
- 2018 Jan;13(1):82-92.
- doi: 10.17085/apm.2018.13.1.82
BACKGROUND: Curcumin is traditionally used as an herbal medicine. We explored the efficacy of intrathecal curcumin in relieving both postoperative and inflammatory pain and elucidated the mechanisms of action of... -
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- Opioids and Antidepressants for Pain Control in Musculoskeletal Disease
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Park SJ, Kim WS, Jang T
- KMID: 2470764
- J Korean Orthop Assoc.
- 2020 Feb;55(1):1-8.
- doi: 10.4055/jkoa.2020.55.1.1
The progression of aging and the increase in musculoskeletal diseases have led to an increase in invasive treatment methods, including various surgical methods, but conservative treatment should be attempted before... -
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- The effects of nalbuphine and fentanyl on experimental spinal cord injuries
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Lee WH
- KMID: 1752552
- Korean J Anesthesiol.
- 1994 May;27(5):428-448.
- doi: 10.4097/kjae.1994.27.5.428
Opiate receptor agonists (especially dynorphin - a kappa receptor agonist) have found to increase in the injuried segment of spinal cord. It is known to cause spinal cord damage when... -
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- Can oliceridine (TRV130), an ideal novel µ receptor G protein pathway selective (µ-GPS) modulator, provide analgesia without opioid-related adverse reactions?
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Ok HG, Kim SY, Lee SJ, Kim TK, Huh BK, Kim KH
- KMID: 2410828
- Korean J Pain.
- 2018 Apr;31(2):73-79.
- doi: 10.3344/kjp.2018.31.2.73
All drugs have both favorable therapeutic and untoward adverse effects. Conventional opioid analgesics possess both analgesia and adverse reactions, such as nausea, vomiting, and respiratory depression. The opioid ligand binds... -
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- Functional activity of the cannabinoid 1 receptor is not affected by opioid antagonists in the rat brain
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Lee H
- KMID: 1767337
- Korean J Anesthesiol.
- 2013 Mar;64(3):257-261.
- doi: 10.4097/kjae.2013.64.3.257
BACKGROUND: WIN55212-2 is a synthetic cannabinoid agonist and selective to cannabinoid 1 (CB1) receptors, which are distributed mainly in the central nervous system. Opioid receptors and CB1 receptors have several... -
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- Effects of Co-Administration of Intrathecal Nociceptin/Orphanin FQ and Opioid Antagonists on Formalin-Induced Pain in Rats
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Lee H
- KMID: 1727895
- Yonsei Med J.
- 2013 May;54(3):763-771.
- doi: 10.3349/ymj.2013.54.3.763
PURPOSE: Nociceptin/orphanin FQ (N/OFQ) as an endogeneous hexadecapeptide is known to exert antinociceptive effects spinally. The aims of this study were to demonstrate the antinociceptive effects of i.t. N/OFQ and... -
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- New Frontiers in Pharmacology
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Lee WC
- KMID: 687775
- Yonsei Med J.
- 1979 Dec;20(2):87-91.
- doi: 10.3349/ymj.1979.20.2.87
No abstract available. -
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- Roles of Opioid Receptor Subtype in the Spinal Antinociception of Selective Cyclooxygenase 2 Inhibitor
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Choi CH, Kim WM, Lee HG, Jeong CW, Kim CM, Lee SH, Yoon MH
- KMID: 1454706
- Korean J Pain.
- 2010 Dec;23(4):236-241.
- doi: 10.3344/kjp.2010.23.4.236
BACKGROUND: Selective inhibitors of cyclooxygenase (COX)-2 are commonly used analgesics in various pain conditions. Although their actions are largely thought to be mediated by the blockade of prostaglandin (PG) biosynthesis,... -
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- Regulation of [3H]Norepinephrine Release by Opioids in Human Cerebral Cortex
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Woo RS, Shin BS, Kim CJ, Shin MS, Jeong MS, Zhao RJ, Kim KW
- KMID: 1607346
- Korean J Physiol Pharmacol.
- 2003 Feb;7(1):1-3.
To investigate the receptors mediating the regulation of norepinephrine (NE) release in human cerebral cortex slices, we examined the effects of opioid agonists for mu-, delta-, and kappa -receptors on... -
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- Intra-articular Morphine for Pain Relief after Arthroscopic Knee Surgery
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Bai SJ, Cho BJ, Nam SH, Lee HC, Ahn EK
- KMID: 2298918
- Korean J Anesthesiol.
- 1998 Jul;35(1):120-124.
- doi: 10.4097/kjae.1998.35.1.120
BACKGROUND: Opioids can produce potent antinociceptive effects by interacting with local opioid receptors in inflamed peripheral tissue. However, reports on pain relief with intra-articular morphine after arthroscopic knee operations are... -
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- The Effects of Repeated Stress on the Opioidergic Neurotransmission in Rats
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Sakong JK, Lee KH, Koo BH, Kim JS, Lee JB, Ha JH
- KMID: 2340324
- J Korean Neuropsychiatr Assoc.
- 1999 May;38(3):638-646.
OBJECTIVES: Research into emotional or behavioral stress typically focuses upon the hypothalamic-pituitary-adrenal axis. It is well established that the hypothalamic-pituitary-adrenocortical axis is subject to inhibitory control by opioids in... -
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- Naltrexone-associated Visual Hallucinations: A Case Report
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Lee DB, Woo YS, Bahk WM
- KMID: 2456739
- Clin Psychopharmacol Neurosci.
- 2019 Mar;17(2):329-331.
- doi: 10.9758/cpn.2019.17.2.329
Naltrexone is a competitive antagonist of μ, δ, and κ opioid receptors. Naltrexone has been investigated for use an as anti-obesity agent in both the general population and in patients... -
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- Changes of the level of G protein alpha-subunit mRNA by withdrawal from morphine and butorphanol
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Oh S
- KMID: 1917022
- Korean J Physiol Pharmacol.
- 2000 Aug;4(4):291-299.
Morphine or butorphanol was continuously infused into cerebroventricle (i.c.v.) with the rate of 26 nmol/microliter/h for 3 days, and the withdrawal from opioid was rendered 7 hrs after the stopping of infusion.... -
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- Effects of an Opiate Receptor Antagonist Naloxone on Endotoxic Shock and Tumorigenesis
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Ha TY, Ko YS, Moon SR
- KMID: 1547846
- Korean J Immunol.
- 1997 Mar;19(1):91-106.
Septic shock is one of the leading cause of death in hospitalized patients and mortality rates of up to 50 % have been reported. Despite all efforts, no regimen today... -
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- Effect of Stellate Ganglion Block with Morphine on Causalgia
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Kim EM, Yoon SG, Paek MH, Kwak HS
- KMID: 2104801
- J Korean Pain Soc.
- 1998 May;11(1):109-112.
The sympathetic nervous system has been implicated as an important factor contributing to causalgia. Basis on reports of presence of opioid receptors in sympathetic autonomic ganglia, including human stellate ganglion, we administered... -
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- Mediation of N-methyl-D-aspartate on neuropeptide Y expression induced by morphine in mouse cerebellum
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Kwon GY, Kim SK
- KMID: 1607136
- Korean J Physiol Pharmacol.
- 2001 Dec;5(6):479-485.
The existence of opioid receptors in mammalian cerebellum except human, has not been clearly understood. In the present study, we found that NPY was inducible by morphine in the mouse... -
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- The Effects of Peripheral mu and kappa Opioid Receptor Agonists on the Thermal Injury Induced Hyperalgesia in the Rat
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Chun YS, Jun JH, Shim JC, Kim KS, Suh JK, Yoo HK, Seung IS
- KMID: 1936000
- Korean J Anesthesiol.
- 2003 Feb;44(2):247-254.
- doi: 10.4097/kjae.2003.44.2.247
BACKGROUND: Previous reports have described that the local administration of opioid receptor agonist can attenuate the nociceptive responses induced by a variety of inflammatory states. This study evaluated the effects... -
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- Studies of G Protein Activation of Orphanin FQ in the Cerebrum, Thalamus and Spinal Cord of Monkeys
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Lee H, Han JI
- KMID: 2032606
- Korean J Anesthesiol.
- 2004 Dec;47(6):877-882.
- doi: 10.4097/kjae.2004.47.6.877
BACKGROUND: The aim of this in vitro study was to investigate [35S]GTP gamma S binding stimulated activation by orphanin FQ in monkey cerebral, thalamic, and spinal membranes. METHODS: A rhesus monkey... -
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- Comprehensive Analysis of Non-Synonymous Natural Variants of G Protein-Coupled Receptors
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Kim HR, Duc NM, Chung KY
- KMID: 2429048
- Biomol Ther.
- 2018 Mar;26(2):101-108.
- doi: 10.4062/biomolther.2017.073
G protein-coupled receptors (GPCRs) are the largest superfamily of transmembrane receptors and have vital signaling functions in various organs. Because of their critical roles in physiology and pathology, GPCRs are... -
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