- The Role of Metabotropic Glutamate Receptors in Psychomotor Stimulant Addiction
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Kim JH, Park HK
- KMID: 2287234
- Korean J Psychopharmacol.
- 2006 Mar;17(2):143-148.
For many years, determining the role of dopamine has been the major focus of the drug abuse research. New evidence, however, suggests that glutamate may play more important roles in... -
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- Altered Expression of Metabotropic Glutamate Receptors mGluR1, mGluR5, and mGluR2/3 in the Diabetic Rat Retina
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Park SH, Park JW, Oh SJ
- KMID: 2224516
- Korean J Anat.
- 2003 Dec;36(6):491-498.
An excitatory neurotransmitter glutamate is engaged in slow transmission by activating the secondary signal transduction pathway through metabotropic receptors of the target cells. The present study has been investigated the... -
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- Roles of Metabotropic Glutamate Receptors in Inhibitory Synaptic Transmission in Rat Medial Vestibular Nucleus Neurons
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Park HY
- KMID: 2195074
- J Korean Neurol Assoc.
- 2003 Jun;21(3):273-282.
BACKGROUND: The medial vestibular nucleus (MVN) is involved in the reflex control of the head and eyes, and the recovery of vestibular function after vestibular lesions. This study was performed... -
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- Role of Principal Ionotropic and Metabotropic Receptors in Visceral Pain
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Kannampalli P, Sengupta J
- KMID: 2381247
- J Neurogastroenterol Motil.
- 2015 Apr;21(2):147-158.
- doi: 10.5056/jnm15026
Visceral pain is the most common form of pain caused by varied diseases and a major reason for patients to seek medical consultation. It also leads to a significant economic... -
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- Modulation of Amygdala Synaptic Transmission by Metabotropic Glutamate Receptors
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Kim JH, Park EJ, Chang DJ, Choi S
- KMID: 1607513
- Korean J Physiol Pharmacol.
- 2003 Dec;7(6):303-306.
Metabotropic glutamate receptors (mGluRs), classified into three groups (group I, II, III), play a critical role in modulation of synaptic transmission at central and peripheral synapses. In the present study,... -
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- Expression of Metabotropic Glutamate Receptors in the Medial Vestibular Nucleus Following Acute Hypotension in Rats
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Choi MA, Kim N, Park SE, Park BG, Kim MS, Park BR
- KMID: 1437733
- Res Vestib Sci.
- 2012 Dec;11(4):131-137.
BACKGROUND AND OBJECTIVES: Acute hypotension induces expression of c-Fos protein and phosphorylated extracellular signal-regulated kinase (pERK), and glutamate release in the vestibular nuclei. Expression of c-Fos protein and pERK is... -
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- Mechanism of Glutamate-induced[Ca2+]i Increase in Substantia Gelatinosa Neurons of Juvenile Rats
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Jung SJ, Choi JS, Kwak J, Kim J, Kim JW, Kim SJ
- KMID: 2285271
- Korean J Physiol Pharmacol.
- 2003 Apr;7(2):53-58.
The glutamate receptors (GluRs) are key receptors for modulatory synaptic events in the central nervous system. It has been reported that glutamate increases the intracellularCa (2+) concentration ([Ca2+]i) and induces... -
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- Metabotropic glutamate receptor dependent long-term depression in the cortex
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Kang SJ, Kaang BK
- KMID: 2364259
- Korean J Physiol Pharmacol.
- 2016 Nov;20(6):557-564.
- doi: 10.4196/kjpp.2016.20.6.557
Metabotropic glutamate receptor (mGluR)-dependent long-term depression (LTD), a type of synaptic plasticity, is characterized by a reduction in the synaptic response, mainly at the excitatory synapses of the neurons. The... -
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- Roles of metabotropic glutamate receptors on excitatory synaptic transmission in rat trigeminal caudal neurons
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Choi JH, Chae SC, Min SK, Chun SW
- KMID: 1515870
- J Korean Assoc Maxillofac Plast Reconstr Surg.
- 2004 Sep;26(5):461-468.
The caudal subnucleus of the spinal trigeminal nucleus (medullary dorsal horn : MDH) is implicated in the processing of nociceptive information in the orofacial region. Whole cell patch clamp recordings... -
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- Effects of Intrathecal Drugs Acting on Metabotropic Glutamate Receptors and Interaction with Morphine on a Rat Incisional Pain
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Nah SS, Bae HB, Kim SJ, Chung ST, Choi JI, Yoon MH, Jeong CY
- KMID: 1514206
- Chonnam Med J.
- 2006 Aug;42(2):108-115.
Spinal metabotropic glutamate receptors (mGluRs) and opioid receptors are involved in the modulation of nociception. Although opioid receptor agonists are active in a postoperative pain, the effects of the agents... -
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- Spinal Metabotropic Glutamate Receptors (mGluRs) are Involved in the Melittin-induced Nociception in Rats
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Cho CH, Shin HK
- KMID: 1486105
- Korean J Physiol Pharmacol.
- 2008 Oct;12(5):237-243.
- doi: 10.4196/kjpp.2008.12.5.237
Intraplantar injection of melittin has been known to induce sustained decrease of mechanical threshold and increase of spontaneous flinchings. The present study was undertaken to investigate how the melittin-induced nociceptive... -
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- Differential effect of homocysteic acid and cysteic acid on changes of inositol phosphates and (Ca2+)i in rat cerebellar granule cells
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Kim WK, Pae YS
- KMID: 2071522
- Korean J Physiol Pharmacol.
- 1998 Feb;2(1):41-48.
The present study was undertaken to characterize homocysteic acid (HCA)-and cysteic acid (CA)mediated formation of inositol phosphates (InsP) in primary culture of rat cerebellar granule cells. HCA and CA stimulated InsP formation in... -
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- The parathyroid hormone-2 receptor: Current status
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Usdin TB
- KMID: 2128620
- Exp Mol Med.
- 1997 Mar;29(1):13-17.
G-protein coupled receptors form a large superfamily of plasma membrane proteins which serve a variety of signal transduction roles. New receptors continue to be identified. Based on sequence homology the... -
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- Antinociceptive Effects of Intrathecal Metabotropic Glutamate Receptor Compounds and Morphine in Rats
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Choi JI, Lee HK, Chung ST, Kim CM, Bae HB, Kim SJ, Yoon MH, Chung SS, Jeong CY
- KMID: 2277949
- Korean J Pain.
- 2005 Jun;18(1):1-9.
- doi: 10.3344/kjp.2005.18.1.1
BACKGROUND: Spinal metabotropic glutamate receptors (mGluRs) and opioid receptors are involved in the modulation of nociception. Although opioid receptors agonists are active for pain, the effects of the compounds for... -
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- The Changes of Glutamate Receptor in Kindled Rats : Metabotropic Glutamate Receptor
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Jung DS, Kim HK, Sohn WS
- KMID: 2333363
- J Korean Epilepsy Soc.
- 2001 Dec;5(2):124-130.
PURPOSE: Kindling refers to a process whereby repeated applications of an initially subconvulsive electrical or chemical stimulus to animals lead to persistent epileptogenic in generalized seizures. Metabotropic glutamate receptors (mGluRs)... -
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- The Role of Central Group I mGluRs for CFA-induced Knee Joint Pain Model in Rats
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Han MA, Chang SH
- KMID: 2236601
- Korean J Anesthesiol.
- 2007 Oct;53(4):504-512.
- doi: 10.4097/kjae.2007.53.4.504
BACKGROUND: Glutamate is the predominant excitatory neurotransmitter in the central and peripheral nervous system and has known to be involved in nociceptive transmission and central sensitization. It acts through ligand... -
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- Roles of Metabotropic Glutamate Receptors 1 and 5 in Rat Medial Vestibular Nucleus Neurons
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Lee HI, Lee SH, Chun SW
- KMID: 2170733
- Int J Oral Biol.
- 2011 Jun;36(2):71-78.
Using whole cell current- and voltage-clamp recording we investigated the characteristics and pharmacology of group I metabotropic glutamate receptor (mGluR)-mediated responses in rat medial vestibular nucleus (MVN) neurons. In current... -
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- Action of Mitochondrial Substrates on Neuronal Excitability in Rat Substantia Gelatinosa Neurons
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Lee HI, Chun SW
- KMID: 2385806
- Int J Oral Biol.
- 2017 Jun;42(2):55-61.
- doi: 10.11620/IJOB.2017.42.2.055
Recent studies indicate that mitochondria are an important source of reactive oxygen species (ROS) in the spinal dorsal horn. In our previous study, application of malate, a mitochondrial electron transport... -
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- Potentiation of Morphine's Antinociception by Group II and Group III Metabotropic Glutamate Receptors Agonists on a Rat Incisional Pain
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Kim CM, Choi JI, Bae HB, Kim SJ, Chung ST, Kim OH, Yoon MH
- KMID: 2073917
- Korean J Pain.
- 2006 Dec;19(2):131-136.
- doi: 10.3344/kjp.2006.19.2.131
BACKGROUND: The aim of this study was to clarify the role of spinal groups II and III metabotropic glutamate receptors (mGluRs) with respect to postoperative pain at the spinal level.... -
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- Involvement of Ionotropic, rather than Metabotropic, Glutamate Receptors in Hyperexcitability of Spinal orsal Neurons Induced after Spinal Cord Injury
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Gwak YS, Shim B, Yoon DM, Nam TS, Paik KS, Leem JW
- KMID: 1946656
- J Korean Pain Soc.
- 2002 Jun;15(1):48-57.
BACKGROUND: Spinal cord injury (SCI) induces the development of central neuropathic pain which is characterized by symptoms such as allodynia, hyperalgesia, and spontaneous pain. However, the underlying mechanism is not... -
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