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Radiation Induced Lung Damage : Mechanisms and Clinical Implications

Oh YT

Radiation therapy is one of most important therapeutic modalities for thoracic malignancies. However, radiation-induced lung damage, such as radiation pneumonitis or fibrosis, is a main dose-limiting factor when irradiating the...
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Bilateral Diffuse Radiation Pneumonitis Caused by Unilateral Thoracic Irradiation: A Case Report

Song SH, Oh YJ, Ha CW, Chae SM

Radiation therapy is one of the most important therapeutic modalities for the treatment of lung cancer. Radiation pneumonitis is one of the important complications associated with radiotherapy for lung cancer....
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The Studies on the Development of Radiation Pneumonitis and Its Related Factors

Suh HS, Rhee CS

  • KMID: 2097259
  • J Korean Soc Ther Radiol.
  • 1987 Dec;5(2):119-130.
With the introduction of X-rays of higher energy that have higher penetrability, it has become possible to treat the deep-seated tumor with increased local control rate. But at the same...
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Radiation Induced Acute Lung Injury: Chest Radiographic Findings

Park SH, Shinn KS, Chung SM, Park JM, Choi IB, Hahn ST, Kim CY

  • KMID: 2102232
  • J Korean Radiol Soc.
  • 1994 Jan;30(1):91-96.
PURPOSE: Radiation pneumonitis and fibrosis are common complications of radiation therapy of the chest. Sixty-six patients with lung cancer were studied to evaluate the radiation injury according to radiation dose (total and...
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Radiation-Induced Pulmonary Injury after Cyberknife Radiosurgery for Lung Malignancy: CT Appearance

Seo JY, Cho YJ, Lee SY, Kim KW, Hwang CM, Kim DH, Kim HJ

  • KMID: 2322622
  • J Korean Soc Radiol.
  • 2011 Sep;65(3):257-265.
PURPOSE: To evaluate the CT appearance of radiation-induced pulmonary injury in patients who have undergone cyberknife radiosurgery for lung malignancy MATERIALS AND METHODS: Thirty-four patients with 39 malignant lung tumors who...
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Radiation pneumonitis

Kim SH, Park JH, Yeon KM, Park CI

Radiologic findings of the 29 cases of radiation pneumonitis and fibrosis diagnosed by chest radiography atSeoul National University Hospital were evaluated and compared with clinical symptoms according to the passage...
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An expermental study of radiation pneumonitis

Kim IO, Choi BI, Kim CW

The study was undertaken to evaluate the radiological and microscopic findings of radiation pneumonitis. All 50 rats, which were used for the experiment, received a single dose of 2,000 rads...
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Factors predicting radiation pneumonitis in locally advanced non-small cell lung cancer

Kim M, Lee J, Ha B, Lee R, Lee KJ, Suh HS

PURPOSE: Thoracic radiotherapy is a major treatment modality of stage III non-small cell lung cancer. The normal lung tissue is sensitive to radiation and radiation pneumonitis is the most important...
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The Study of Normal Tissue Complication Probability (NTCP) for Radiation Pneumonitis by Effective Volume Method

Ahn SD, Choi EK, Yi BY, Chang H

  • KMID: 2196478
  • J Korean Soc Ther Radiol.
  • 1997 Sep;15(3):243-250.
PURPOSE: In radiation therapy, NTCP is very important indicator of selecting the optimal treatment plan. In our study, we tried to find out usefullness of NTCP in lung cancer by...
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The clinical characteristics of radiation pneumonitis

Lee JH, Hyun IG, Choi DC, Yu CG, Song JH, Jung KS, Kim YW, Han SK, Shim YS, Kim KY, Han YC, Park CI

  • KMID: 1697806
  • Korean J Intern Med.
  • 1991 Mar;40(3):386-392.
No abstract available.
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Internal Mammary Lymph Node Irradiation after Breast Conservation Surgery: Radiation Pneumonitis versus Dose?Volume Histogram Parameters

Kim JY, Lee IJ, Keum KC, Kim YB, Shim SJ, Jeong K, Kim JD, Suh CO

  • KMID: 2198503
  • J Korean Soc Ther Radiol Oncol.
  • 2007 Dec;25(4):261-267.
PURPOSE: To evaluate the association between radiation pneumonitis and dose-volume histogram parameters and to provide practical guidelines to prevent radiation pneumonitis following radiotherapy administered for breast cancer including internal mammary...
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An Experimental Study on the Radiation-induced Injury of the Rabbit Lung: Correlation of Soft-tissue Radiograph and High-Resolution CT Findings with Pathologic Findings

Lee KN, Park BH, Nam KJ, Jeong JS, Lee HS

  • KMID: 2117227
  • J Korean Radiol Soc.
  • 1994 Oct;31(4):657-666.
PURPOSE: To describe soft-tissue radiographic and high-resolution CT findings of radiation-induced lung injury of rabbit over time and to correlate them with pathologic findings. MATERIALS AND METHODS: 15 rabbits were irradiated in...
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CT findings of radiation-induced pulmonary injury

Song CS, Cho WH, Im JG

Authors analyzed 21 cases of CT findings of radiation-induced pulmonary injury. Alveolar consoliation and partial fibrotic change of the irradiated field were early manifestation followed by total fibrotic change, atelectatic...
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Imaging Feature of Radiation Induced Lung Disease

Lee JG, Rho BH, Chang JC, Kim MS

BACKGROUND AND PURPOSE: Radioopaque lesions are commonly seen in patients who received thoracic radiotherapy for various kinds of thoracic neoplasm, But therir exact diagnos are sometimes uncertain. PATIENTS AND METHODS:...
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Radiation Effect on NO, NOS and TGF-beta Expressions In Rat Lung

Oh YT, Park KJ, Kil HJ, Ha MJ, Chun M, Kang SH, Park SE, Chang SK

  • KMID: 1571433
  • J Korean Soc Ther Radiol Oncol.
  • 2000 Dec;18(4):321-328.
PURPOSE: NOS2 induce NO production and NO activate TGF-beta. The TGF-beta is a inhibitor of NOS2. If this negative feedback mechanism operating in radiation pneumonitis model, NOS2 inhibitor may play...
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Probabilities of Pulmonary and Cardiac Complications and Radiographic Parameters in Breast Cancer Radiotherapy

Noh OK, Park SH, Ahn SD, Choi EK, Lee SW, Song SY, Yoon SM, Kim JH

PURPOSE: To evaluate the relationship between the normal tissue complication probability (NTCP) of 3- dimensional (3-D) radiotherapy and the radiographic parameters of 2-dimensional (2-D) radiotherapy such as central lung distance...
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Radiation-induced Pulmonary Damage in Lung Cancer Patients

Chung SM, Choi IB, Kang KM, Kim IA, Shinn KS

  • KMID: 2097441
  • J Korean Soc Ther Radiol.
  • 1993 Dec;11(2):321-330.
PURPOSE: A retrospective analysis was performed to evaluate the incidence of radiation induced lung damage after the radiation therapy for the patients with carcinoma of the lung. MATHOD AND MATERIALS: Sixty-six...
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The Measurements of Plasma Cytokines in Radiation-induced Pneumonitis in Lung Cancer Patients

Hur WJ, Youn SM, Lee HS, Yang KM, Oh SG, Son CH, Han JY, Lee KN, Jeong MH

  • KMID: 1571432
  • J Korean Soc Ther Radiol Oncol.
  • 2000 Dec;18(4):314-320.
PURPOSE: To investigate whether changes in plasma concentrations of transforming growth factor-beta1 (TGF-beta1), tumor necrosis factor-alpha (TNF-alpha) and interleukin-6 (IL-6) could be used to identify the development of radiation-induced pneumonitis...
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Pathologic Changes in the Rabbit lung Following Single Dose irradiation

Lee HS, Choi YM, Hur WJ, Jeong JS, Yuh YH, Lee KN

  • KMID: 2196752
  • J Korean Soc Ther Radiol.
  • 1994 Jun;12(2):143-150.
The damage which radiation produces in tissues such as the lungs can be discussed at the molecular, biophysical, cellular, and organ levels. The cellular effects of irradiating the lungs are...
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Histomorphologic Change of Radiation Pneumonitis in Rat Lungs : Captopril Reduces Rat Lung Injury Induced by Irradiation

Kim JH

  • KMID: 1557169
  • J Korean Soc Ther Radiol Oncol.
  • 1999 Sep;17(3):238-248.
PURPOSE: To assess the histomorphologic changes in the rat lung injury induced by radiation, to determine whether captopril reduces the rat lung injury and to evaluate change in TNF-alpha and...
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