- Dynamic expressions of proto-oncogenes in chronic hepatitis, liver cirrhosis and hepatocellular carcinoma
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Lee DH, Park SS, Shin DH, Roe IH, Kwon KW, Yoo BM, Kang KW, Lee JD
- KMID: 1685411
- Korean J Gastroenterol.
- 1992 Jun;24(3):535-546.
No abstract available. -
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- Expressional Changes of c-fos, c-jun, and c-myc Induced by 12-O-tetradecanoylphorbol 13-acetate (TPA) in HaCaT Cells
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Kim JY
- KMID: 1514944
- Korean J Anat.
- 2003 Jun;36(3):215-224.
Proto-oncogenes (c-fos, c-jun, c-myc) are major nuclear target for signal transduction pathways involved in the regulation of cell growth, differentiation, and transformation. To investigate expressional changes of proto-oncogene induced by... -
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- Molecular Pathogenesis and Targeted Therapies in Well-Differentiated Thyroid Carcinoma
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Kim JG
- KMID: 2169455
- Endocrinol Metab.
- 2014 Sep;29(3):211-216.
- doi: 10.3803/EnM.2014.29.3.211
Four proto-oncogenes commonly associated with well-differentiated thyroid carcinoma, rearranged during transfection (RET)/papillary thyroid cancer, BRAF, RAS, and PAX8/peroxisome proliferator activated receptor-gamma, may carry diagnostic and prognostic significance. These oncogenes can... -
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- Change in Expression of Keratin and Proto-oncogene Induced by Beta-propiolactone in HaCaT Cell
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Liu Y, Sung EG, Song IH, Du D, Kim DK, Park JH, Sung HK, Lee Y, Kim JY
- KMID: 1559031
- Korean J Anat.
- 2001 Aug;34(4):389-404.
To investigate the relationship between the morphologic changes and the expression of keratin and proto-oncogene induced by Beta-propiolactone (BPL), we assessed on the expression of keratins (K8, K10, K13) and... -
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- Cell Beath Induced by Ethanol : Prevention of Cell Death by the bcl-2 Proto-Oncogene
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Lim EJ, Hong KJ, Yang BH, Chai YG
- KMID: 2202982
- J Korean Soc Biol Psychiatry.
- 1997 Nov;4(2):211-218.
The Bcl-2 protein has been shown to block apoptosis induced by a variety of stimuli. We have performed the experiments which cell death can be blocked by the bcl-2 proto-oncogene... -
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- Mouse Models as a Tool for Understanding Progression in Braf(V600E)-Driven Thyroid Cancers
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Landa I, Knauf JA
- KMID: 2441674
- Endocrinol Metab.
- 2019 Mar;34(1):11-22.
- doi: 10.3803/EnM.2019.34.1.11
The development of next generation sequencing (NGS) has led to marked advancement of our understanding of genetic events mediating the initiation and progression of thyroid cancers. The NGS studies have... -
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- Immunohistochemical Study of c - Myc, c - Fos and c - Jun Oncoprotein Expression in the Human Pheochromocytoma
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Jo JW, Lee EJ, Nam MS, Kim KR, Nam SY, Song YD, Lim SK, Lee HC, Huh KB, Lee YH, Kim TS, Lee KW
- KMID: 2461540
- J Korean Soc Endocrinol.
- 1995 Mar;10(1):26-34.
A large number of studies for genes involved in oncogenesis have been done during last decade. Over 20 oncogenes have been isolated characterized, and the oncogene expressions in human tumors... -
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- A Case of Sporadic Medullary Thyroid Cancer with RET G691S Polymorphism
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Kang MK, Lee JM, Kim JH, Lee MY, Kim JH, Moon SD, Han JH, Chang SA
- KMID: 1468551
- J Korean Endocr Soc.
- 2009 Dec;24(4):293-297.
- doi: 10.3803/jkes.2009.24.4.293
Sporadic medullary thyroid carcinoma (MTC) is the most common form of MTC and somatic RET proto-oncogene mutations account for approximately 25% of the patients with sporadic MTC. However, other pathogeneses... -
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- A family of multiple endocrine neoplasia type 2A associated with a C618R mutation in RET proto-oncogene
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Kim NH, Kim JH, Nam JH, Park JP, Park JE, Choi YS, Park YH
- KMID: 1833332
- Korean J Med.
- 2006 Apr;70(4):448-454.
Medullary thyroid carcinoma (MTC) is a relatively rare malignant thyroid disease that accounts for approximately 1% to 5% of all thyroid carcinomas. MTC occurs as a sporadic disease and as... -
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- Convergence of Cancer Metabolism and Immunity: an Overview
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Van Dang C, Kim JW
- KMID: 2400809
- Biomol Ther.
- 2018 Jan;26(1):4-9.
- doi: 10.4062/biomolther.2017.194
Cancer metabolism as a field of research was founded almost 100 years ago by Otto Warburg, who described the propensity for cancers to convert glucose to lactate despite the presence... -
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- Multiple Endocrine Neoplasia Type IIa Report of three cases
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Park JH, Lee HK, Nam SJ, Jung JH, Lee MS, Yang JH
- KMID: 1895988
- J Korean Surg Soc.
- 2000 Jul;59(1):115-123.
PURPOSE: Multiple endocrine neoplasia (MEN) type IIa is a syndrome composed of pheochromocytoma, a medullary thyroid carcinoma, and parathyroid hyperplasia with autosomal dominant inheritance. The syndrome is rare, but has... -
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- MicroRNA Dysregulations in Gastrointestinal Cancers: Pathophysiological and Clinical Perspectives
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Wu WK, Sung JJ
- KMID: 2174248
- Intest Res.
- 2012 Oct;10(4):324-331.
- doi: 10.5217/ir.2012.10.4.324
Two common gastrointestinal cancers, namely, gastric and colorectal cancers, cause high mortality and morbidity. The development of gastrointestinal cancers usually follows stepwise processes with recognizable pre-neoplastic changes. A class of... -
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- A Case of Multiple Endocrine Neoplasia Type 2B early Diagnosis by RET Proto-oncogene Analysis and Prophylactic Total Thyroidectomy
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Kim BS, Rhie YJ, Koh H, Kim DH, Choi SH
- KMID: 1510419
- J Korean Soc Pediatr Endocrinol.
- 2006 Jun;11(1):104-109.
Multiple endocrine neoplasia type 2B (MEN 2B) is a rare autosomal-dominant hereditary syndrome which includes medullary thyroid carcinoma (MTC), pheochoromocytoma, multiple ganglioneuromas, gastrointestinal disorders and marfanoid face. MTC is the... -
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- Mutation Profile of Well-Differentiated Thyroid Cancer in Asians
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Song YS, Lim JA, Park YJ
- KMID: 2407074
- Endocrinol Metab.
- 2015 Sep;30(3):252-262.
- doi: 10.3803/EnM.2015.30.3.252
Recent advances in molecular diagnostics have led to significant insights into the genetic basis of thyroid tumorigenesis. Among the mutations commonly seen in thyroid cancers, the vast majority are associated... -
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- A Family of Multiple Endocrine Neoplasia Type 2A with a C634R Mutation and a G691S Polymorphism in RET Proto-oncogene
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Yun SW, Yoo WS, Hong KH, Kim BH, Kang MH, Choo YK, Park HY, Kim DH, Chung HK, Chang MC, Kwon MS, Kim HJ
- KMID: 1958911
- J Korean Endocr Soc.
- 2007 Dec;22(6):453-459.
- doi: 10.3803/jkes.2007.22.6.453
Multiple endocrine neoplasia type 2A (MEN2A) is an autosomal dominant syndrome characterized by the presence of a medullary thyroid carcinoma, pheochromocytoma and hyperparathyroidism. MEN2A arises due to germline missense mutations... -
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- Amplification and Overexpression of c-erbB-2 in Gastric Cancer
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Jun SY, Chung HY, Lee SC, Huh TL, Yu W
- KMID: 2175010
- J Korean Cancer Assoc.
- 2000 Jun;32(3):467-475.
PURPOSE: We compared c-erbB-2 oncogene amplification and oncoprotein expression, trying to identify the biologic and prognostic significance of c-erbB-2 in adendegrees Carcinoma of the stomach. MATERIALS AND METHODS: Formalin-fixed, paraffin-embedded tissue sections... -
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- A Case of Familial Medullary Thyroid Carcinoma with a E768D Mutation in RET Proto-Oncogene
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Kim YK, Kim JW, Ahn SM, Song KE, Jung SH, Kim DJ, Chung YS, Lee KW, Kim CH, Hong JH, Jeong SY, Kim HJ
- KMID: 2100468
- J Korean Soc Endocrinol.
- 2005 Aug;20(4):375-380.
- doi: 10.3803/jkes.2005.20.4.375
A medullary thyroid carcinoma, a neoplasm of parafollicular C cell origin, occurs as a sporadic or hereditary disease. A hereditary medullary thyroid carcinoma is an autosomal dominantly inherited disease, which... -
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- Multiple Endocrine Neoplasia and Familial Medullary Thyroid Carcinoma
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Choi YS
- KMID: 2095101
- J Korean Thyroid Assoc.
- 2012 Nov;5(2):124-131.
- doi: 10.11106/jkta.2012.5.2.124
Multiple endocrine neoplasia (MEN) is defined as a disorder with neoplasms in two or more different hormonal tissues in several members of a family. MEN1, or Wermer's syndrome, is inherited... -
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- The Value of the Expression of bel-2 and p53 in Colorectal Carcinomas
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Chang JH, Clung KH, Kim KC, Kim CY
- KMID: 1944911
- J Korean Soc Coloproctol.
- 1997 Mar;13(1):31-42.
There are a lots of evidences that colorectal cancer arise as a result of multiple alterations of genes. Many attempts were made to understand the role of oncogenes and suppressor... -
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- Analysis of c-Kit Gene Polymorphism in NK/T Cell Lymphoma in Korean Population
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Kim HJ, Baek SK, Jung KY, Lee SH, Kwon SY, Choi HY
- KMID: 1597347
- Korean J Otolaryngol-Head Neck Surg.
- 2005 May;48(5):641-645.
BACKGROUND AND OBJECTIVES: The proto-oncogene c-KIT encodes a receptor tyrosine kinase (KIT) whose ligand is a stem cell factor. KIT is expressed and critical for the development and growth of... -
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