- Regulation of bcl-2 family in hydrogen peroxide-induced apoptosis in human leukemia HL-60 cells
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Lee JE, Sohn JW, Lee JH, Lee KC, Son CS, Tockgo YC
- KMID: 927133
- Exp Mol Med.
- 2000 Mar;32(1):42-46.
Numerous types of cells have been shown to undergo apoptosis when exposed to oxidant agent such as hydrogen peroxide. In order to understand the functional relationship between the anti- and... -
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- Aspirin-induced Bcl-2 translocation and its phosphorylation in the nucleus trigger apoptosis in breast cancer cells
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Choi BH, Chakraborty G, Baek K, Yoon HS
- KMID: 2154266
- Exp Mol Med.
- 2013 Oct;45(10):e47.
Here, we report that B-cell lymphoma 2 (Bcl-2) is a novel target molecule of aspirin in breast cancer cells. Aspirin influenced the formation of a complex by Bcl-2 and FKBP38... -
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- TGF-beta1 inhibition of apoptosis through the transcriptional up-regulation of Bcl-X(L) in human monocytic leukemia U937 cells
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Lee JH, Park BJ, Park JH, Yang MH, Chi SG
- KMID: 755040
- Exp Mol Med.
- 1999 Sep;31(3):126-133.
To characterize the TGF-beta1 response of monocytic leukemia cells, we analyzed the effects of TGF-beta1 on cell proliferation, differentiation, and apoptosis of human monoblastic U937 cells. Treatment of cells with TGF-beta1 in... -
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- Bfl-1 Gene Expression in Breast Cancer: Its Relationship with other Prognostic Factors
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Yoon HS, Hong SH, Kang HJ, Ko BK, Ahn SH, Huh JR
- KMID: 2157626
- J Korean Med Sci.
- 2003 Apr;18(2):225-230.
- doi: 10.3346/jkms.2003.18.2.225
The Bfl-1 gene, which was isolated from human fetal liver and only recently described, is a member of the Bcl-2 gene family. Reverse transcriptase-polymerase chain reaction was performed on RNA... -
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- Prognostic Value of p53 and bcl-2 Expression in Patients Treated with Breast Conservative Therapy
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Kim K, Chie EK, Han W, Noh DY, Park IA, Oh DY, Im SA, Kim TY, Bang YJ, Ha SW
- KMID: 1779253
- J Korean Med Sci.
- 2010 Feb;25(2):235-239.
- doi: 10.3346/jkms.2010.25.2.235
Prognostic value of p53 and bcl-2 expression on treatment outcome in breast cancer patients has been extensively evaluated, but the results were inconclusive. We evaluated the prognostic significance of these... -
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- Activation of the intrinsic mitochondrial apoptotic pathway in swine influenza virus-mediated cell death
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Choi YK, Kim TK, Kim CJ, Lee JS, Oh SY, Joo HS, Foster DN, Hong KC, You S, Kim H
- KMID: 1105272
- Exp Mol Med.
- 2006 Feb;38(1):11-17.
The mitochondrial pathway of swine influenza virus (SIV)-induced apoptosis was investigated using porcine kidney (PK-15) cells, swine testicle (ST) cells, and HeLa cervical carcinoma cells which are known not to... -
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- Enhancement of radiosensitivity by combined ceramide and dimethylsphingosine treatment in lung cancer cells
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Park HW, Song JY, Kim KS, Han Y, Kim CW, Yi SY, Yun YS
- KMID: 1123762
- Exp Mol Med.
- 2004 Oct;36(5):411-419.
Ceramide generated from sphingomyelin in response to ionizing radiation has been implicated as a second messenger to induce cellular proapoptotic signals. Both ceramide and its metabolic inhibitor, N, N-dimethyl-D-erythro-sphingosine (DMS),... -
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- Endothelin A Receptor Blockade Influences Apoptosis and Cellular Proliferation in the Developing Rat Kidney
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Yoo KH, Yim HE, Jang GY, Bae IS, Choi BM, Hong YS, Lee JW
- KMID: 1794420
- J Korean Med Sci.
- 2009 Feb;24(1):138-145.
- doi: 10.3346/jkms.2009.24.1.138
Endothelin systems are believed to play important roles in the emergence and maintenance of functions of various organs during perinatal development, including the kidney. The present study was designed to... -
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- Capsaicin-Induced Apoptosis of FaDu Human Pharyngeal Squamous Carcinoma Cells
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Le TD, Jin DC, Rho SR, Kim MS, Yu R, Yoo H
- KMID: 1716886
- Yonsei Med J.
- 2012 Jul;53(4):834-841.
- doi: 10.3349/ymj.2012.53.4.834
PURPOSE: To investigate the anti-tumor effect of capsaicin on human pharyngeal squamous carcinoma cells (FaDu). MATERIALS AND METHODS: The expression of apoptosis/cell cycle-related proteins (or genes) was examined by reverse transcriptase-polymerase... -
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- Pregabalin as a Neuroprotector after Spinal Cord Injury in Rats: Biochemical Analysis and Effect on Glial Cells
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Ha KY, Carragee E, Cheng I, Kwon SE, Kim YH
- KMID: 2157879
- J Korean Med Sci.
- 2011 Mar;26(3):404-411.
- doi: 10.3346/jkms.2011.26.3.404
As one of trials on neuroprotection after spinal cord injury, we used pregabalin. After spinal cord injury (SCI) in rats using contusion model, we observed the effect of pregabalin compared... -
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- ATM modulates transcription in response to histone deacetylase inhibition as part of its DNA damage response
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Jang ER, Choi JD, Park MA, Jeong G, Cho H, Lee JS
- KMID: 946652
- Exp Mol Med.
- 2010 Mar;42(3):195-204.
- doi: 10.3858/emm.2010.42.3.020
Chromatin structure has a crucial role in a diversity of physiological processes, including development, differentiation and stress responses, via regulation of transcription, DNA replication and DNA damage repair. Histone deacetylase... -
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