- Proteolytic Regulation of Retinoblastoma Family Protein p107 by Ubiquitin - proteasome Pathway
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Jang JS, Park BK, Hwang SG
- KMID: 2175114
- J Korean Cancer Assoc.
- 2000 Apr;32(2):417-421.
PURPOSE: Proteolysis is an important way to regulate cell cycle regulatory proteins. Ubiquitin- proteasome pathway regards as highly selective proteolytic machinary mostly in physiological state. We investigated the role of ubiquitin-proteasome pathway... -
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- Role of IL-15 in Sepsis-Induced Skeletal Muscle Atrophy and Proteolysis
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Kim HC, Cho HY, Hah YS
- KMID: 1842924
- Tuberc Respir Dis.
- 2012 Dec;73(6):312-319.
- doi: 10.4046/trd.2012.73.6.312
BACKGROUND: Muscle wasting in sepsis is associated with increased proteolysis. Interleukin-15 (IL-15) has been characterized as an anabolic factor for skeletal muscles. Our study aims to investigate the role of... -
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- The Molecular Biologic Study about the Role of Deubiquitination Gene in Bladder Tumor Progression
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Kim HY, Lee YG, Lee SE
- KMID: 2292517
- Korean J Urol.
- 2002 Dec;43(12):1019-1023.
PURPOSE: Ubiqutin-proteasome-mediated proteolysis is an important pathway of nonlysosomal protein degradation, which controls the timed destruction of cellular regulatory proteins of the p21, p27, p53 gene (p53), Retinoblastoma gene (Rb),... -
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- The Effect of Obesity on Serum Growth Factors, and Insulin-like Growth Factor Binding Protein-3 Proteolysis in Children with Simple Obesity
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Lee SW, Rhie YJ, Hwang IT, Han DK, Kim DH, Kim HS
- KMID: 1838796
- J Korean Soc Pediatr Endocrinol.
- 2005 Dec;10(2):195-203.
PURPOSE: In children with simple obesity, spontaneous and stimulated growth hormone (GH) secretion are diminished, but their heights usually are normal or even taller for their age and sex. The... -
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- Regulation of Insulin Signaling through Protein Degradation
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Lee MY, Baek KH
- KMID: 2200589
- J Korean Soc Endocrinol.
- 2005 Oct;20(5):434-440.
- doi: 10.3803/jkes.2005.20.5.434
No abstract available. -
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- Nutrition Therapy in Critically Ill Patients
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Hong SK
- KMID: 2137278
- J Korean Diabetes.
- 2015 Mar;16(1):11-17.
- doi: 10.4093/jkd.2015.16.1.11
Nutrition therapy is challenging in critically ill patients. Critical illness is associated with a state of catabolic stress, in which stress hormones and inflammatory mediators are activated, resulting in proteolysis.... -
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- Associations of Ubiquitin-Specific Protease Genes with Resilience and Social Anxiety in Healthy Youths
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Seo JH, Park CI, Kim SJ, Kang JI
- KMID: 2464998
- Anxiety Mood.
- 2019 Oct;15(2):122-126.
- doi: 10.24986/anxmod.2019.15.2.122
OBJECTIVE: Dynamic proteolysis, through the ubiquitin-proteasome system, is an important molecular mechanism for the constant regulation of synaptic plasticity and stress responses in humans. In this study, we examined whether... -
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- Differential Regulation of Antioxidant Enzymes during Monocyte Differentiation
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Lee YS, Kang SS, Kim EJ
- KMID: 1547852
- Korean J Immunol.
- 1997 Mar;19(1):121-128.
Antioxidant enzymes levels were determined in monocytes during phorbol myristate acetate (PMA)-induced differentiation. PMA induced the differentiation of a human monocytic leukemia cell line THP-1 into macrophage-like cells as indicated... -
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- Spectrin Cleavage Induced by LLP-1 Lentivirus Lytic Peptide Domain in the Intracytoplasmic Tail of Human Immunodeficiency Virus Type 1 GP41 in Rat Organotypic Hippocampal Slice Cultures
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Lee JH, Lee EO, Chong YH
- KMID: 2055033
- J Bacteriol Virol.
- 2006 Dec;36(4):247-254.
- doi: 10.4167/jbv.2006.36.4.247
We previously demonstrated that the lentivirus lytic peptide 1 (LLP-1) corresponding to the carboxyl terminus of HIV-1 gp41 induced cell death in human neuronal cells. Present study was conducted to... -
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- Systemic Administration of a Novel Calpain Inhibitor Attenuates Subarachnoid Hemorrhage Induced Vasospasm
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Kang SD
- KMID: 1955635
- J Korean Neurosurg Soc.
- 1998 Feb;27(2):146-153.
The calcium-sensitive neutral protease, calpain, is activated in the basilar artery after subarachnoid hemorrhage. Pathological activation of this proteolytic enzyme has been suggested to contribute to cerebral vasospasm after subarachnoid... -
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- NR1/NR2B receptor Activation induces Cytoskeletal Proteolysis in Partial Ischemic Rat Hippocampal Formation
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Jung YW, Moon IS, Ko BH
- KMID: 2030723
- Korean J Anat.
- 1997 Oct;30(5):439-452.
In the rat brain, partial ischemia causes a delayed neuronal degeneration that occurs hours to days after reoxygenation. It is generally thought that the ischemic damage is initiated by neurotoxicity... -
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- Characterization of proteases isolated from Kudoa septempunctata
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Shin SP, Zenke K, Yokoyama H
- KMID: 2049852
- Korean J Vet Res.
- 2015 Sep;55(3):175-179.
- doi: 10.14405/kjvr.2015.55.3.175
Proteases play important roles in parasite development and host parasite interactions. The protease of Kudoa spp. has been recognized as a key factor of severe proteolysis of fish muscle post-mortem;... -
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- Expression of 72 kDa Type IV Collagenase in Human Colorectal Cancer
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Jun SH, Kim JE, Sohn KY
- KMID: 2206255
- J Korean Surg Soc.
- 1997 Jul;53(1):79-86.
Type IV collagenases are thought to play a role in the proteolysis of the basement membrane and the extracellular matrix by the malignant cells that occur early in the development... -
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- Kainic Acid Treatment Increases Ca²âº-mediated Neurotoxicity in the Mouse Hippocampus
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Lee JE
- KMID: 2328103
- Korean J Phys Anthropol.
- 2016 Jun;29(2):71-79.
- doi: 10.11637/kjpa.2016.29.2.71
Kainic acid (KA)-induced neuronal cell death is associated with intracellular Ca²⺠influx. However, it is unknown whether Lyn/Btk pathway is involved in the Ca²âº-mediated neurotoxicity and neuronal death induced by... -
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- Definition, Epidemiology and Pathogenesis of Chronic Obstructive Pulmonary Disease
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Kim HJ
- KMID: 1958283
- J Korean Med Assoc.
- 2006 Apr;49(4):297-304.
- doi: 10.5124/jkma.2006.49.4.297
Aworking definition of chronic obstructive pulmonary disease (COPD) is given within the GOLD Global strategy as a disease state characterized by airflow limitation that is not fully reversible. The airflow... -
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- Nutrition therapy in the intensive care unit
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Hong SK
- KMID: 1958086
- J Korean Med Assoc.
- 2014 Jun;57(6):496-499.
- doi: 10.5124/jkma.2014.57.6.496
Nutrition therapy is challenging in critically ill patients. Critical illness is associated with a state of catabolic stress, in which stress hormones and inflammatory mediators are activated, resulting in proteolysis.... -
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- Sarcopenia: Ammonia metabolism and hepatic encephalopathy
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Jindal A, Jagdish RK
- KMID: 2459788
- Clin Mol Hepatol.
- 2019 Sep;25(3):270-279.
- doi: 10.3350/cmh.2019.0015
Sarcopenia (loss of muscle mass and/or strength) frequently complicates liver cirrhosis and adversely affects the quality of life; cirrhosis related liver decompensation and significantly decreases wait-list and post-liver transplantation survival.... -
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- The Role and Regulatory Mechanism of 14-3-3 Sigma in Human Breast Cancer
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Ko S, Kim JY, Jeong J, Lee JE, Yang WI, Jung WH
- KMID: 2286347
- J Breast Cancer.
- 2014 Sep;17(3):207-218.
- doi: 10.4048/jbc.2014.17.3.207
PURPOSE: 14-3-3 sigma (sigma) is considered to be an important tumor suppressor and decreased expression of the same has been reported in many malignant tumors by hypermethylation at its promoter... -
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- Mechanisms of Muscle Wasting in Patients with Sepsis
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Lee GD, Kim HC
- KMID: 2301449
- Korean J Crit Care Med.
- 2010 Mar;25(1):9-15.
- doi: 10.4266/kjccm.2010.25.1.9
Muscle wasting is commonly seen in patients with sepsis as a consequence of the catabolic response in skeletal muscle. Muscle wasting can occur in cases that have an imbalance between... -
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- Crystalline podocytopathy and tubulopathy without overt glomerular proteinuria in a patient with multiple myeloma
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Lee EJ, Lee SY, Park SY, Kim Y, Choi JS, Kim MJ, Park JH, Lee JE, Kwon GY, Kim YG
- KMID: 2364293
- Kidney Res Clin Pract.
- 2016 Dec;35(4):259-262.
- doi: 10.1016/j.krcp.2016.06.001
Crystalline nephropathy is a rare yet well-known condition associated with multiple myeloma and other light chain–secreting disorders. Paraproteins that are resistant to proteolysis crystallize within proximal tubular cells and cause... -
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