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Proapoptotic role of nuclear clusterin in brain

Kim N, Choi WS

Clusterin (CLU) is a multifunctional glycoprotein that has secretory and nuclear isoforms. The two isoforms are known to play opposite roles in cell survival/death. In this review, we summarize recent...
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Vitamin E: alpha-Tocopherol and the Other Forms of Vitamin E

Cho SH

Vitamin E has been a generic term for all tocopherol and tocotrienol derivatives. The most active form of vitamin E isoforms in vivo is regarded to be alpha-tocopherol which is...
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Expression of Superoxide Dismutase Isoforms in Inflamed Gingiva

Na HJ, Kim OS, Park BJ

  • KMID: 2462853
  • J Korean Acad Periodontol.
  • 2006 Mar;36(1):97-112.
No abstract available.
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Proteomic Analysis of the Serum in Patients with Acute Coronary Syndrome

Bang DW, Hyun MS, Kim SK, Kwon YJ

BACKGROUND AND OBJECTIVES: Proteomics is a new technology that allows the detection and identification of several proteins at a given time in a sample. There are currently few reports concerned...
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UVC induced translocation of protein kinase C (PKC) and expression change of c-myc oncogene in human skin keratinocytes

Lee IH

  • KMID: 1937891
  • Korean J Anat.
  • 1998 Oct;31(5):799-805.
Recent studies have documented that UVC induced DNA damage leads to activation of protein kinase C (PKC) isoforms, which result in the transient expression of immediate early gene expression, then...
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Role of Protein Kinase C Signaling in Intestinal Ischemic Preconditioning

Um JW

  • KMID: 2025805
  • J Korean Soc Coloproctol.
  • 2003 Jun;19(3):177-190.
Ischemic preconditioning (IPC) is a phenomenon that a brief episode of ischemia to a tissue renders the tissue resistance from a subsequent prolonged ischemia. It is generally accepted that this...
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Distribution of caveolin isoforms in the lemur retina

Berta AI, Kiss AL, Lukats A, Szabo A, Szel A

The distribution of caveolin isoforms was previouslyevaluated in the retinas of different species, but has notyet been described in the primate retina. In this study, thedistribution of caveolins was assessed...
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Production of Monoclonal Antibody Against Human 14 - 3 - 3 Zeta Isoform Expressed in Escherichia coli

Lim BU, Kang JS, Kim JW, Choi NJ

  • KMID: 2083005
  • Korean J Immunol.
  • 1997 Sep;19(3):391-398.
14-3-3 proteins are cytoplasmic proteins of about 29 kDa and have a minimum of seven isoforms. This protein is important in signal transduction with the ability of binding with phosphoserine...
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Differential Expression of TGF-beta Isoforms in Human Kerationocytes by Narrow Band UVB

Jung MC, Shin MK, Hong KK, Jeong KH, Kim NI

BACKGROUND: Transforming growth factor-beta (TGF-beta), a multifunctional growth factor, has three isoforms: TGF-beta1, TGF-beta2, and TGF-beta3. Different isoforms of TGF-beta are associated with different proliferation and differentiation states of the...
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Role of hepcidin in the pathophysiology and diagnosis of anemia

D'Angelo G

This review summarizes the central role of hepcidin in the iron homeostasis mechanism, the molecular mechanism that can alter hepcidin expression, the relationship between hepcidin and erythropoiesis, and the pathogenetic...
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Quantitative Analysis of Myosin Heavy Chain (MHC) mRNA expression in Thyropharyngeus muscle and Cricopharyngeus muscle in Rats

Park YS, Jung HH, Nam SY

  • KMID: 1874321
  • Korean J Otolaryngol-Head Neck Surg.
  • 2000 Mar;43(3):300-305.
BACKGROUNDS: The inferior pharyngeal constrictor muscle (IPC), which consists of the thyropharyngeus (TP) and cricopharyngeus (CP) muscles, plays an important role during deglutition, but their function is different when analysed...
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Do PML/RAR-alpha isoforms have clinical significance in patients with acute promyeloctyic leukemia?

Eom HS

  • KMID: 2081519
  • Korean J Med.
  • 2008 Oct;75(4):409-411.
Acute promyelocytic leukemia (APL) is characterized by a specific t (15;17) translocation which produce a PML/RAR-alpha fusion messenger RNA and by effectiveness of all-trans retinoic acid (ATRA) differentiation therapy. Breakpoints...
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Alternative Isoforms of TonEBP with Variable N-termini are Expressed in Mammalian Cells

Kim HS, Son SJ, Kim SN, Kim YD, Kim KJ, Jeon BH, Park JB, Lee SD

  • KMID: 2285337
  • Korean J Physiol Pharmacol.
  • 2007 Jun;11(3):135-138.
Hypertonicity imposes a great deal of stress to cells since it causes rise in cellular ionic strength, which can be reduced by the accumulation of compatible osmolytes. TonEBP plays a...
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Prostaglandin E2 Receptors on Upper Respiratory Tract

Kim JK

Prostaglandin (PG) E2 exerts its actions by acting on a group of G-protein-coupled receptors (GPCRs). GPCRs responding to PGE2 consist of four subtypes namely E-prostanoid 1 (EP1), E-prostanoid 2 (EP2),...
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Ferulic acid modulates nitric oxide synthase expression in focal cerebral ischemia

Koh PO

Nitric oxide (NO) is generated by three different NO synthase (NOS) isoforms, endothelial NOS (eNOS), inducible NOS (iNOS), and neuronal NOS (nNOS). It is known that eNOS produces NO, which...
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Immunohistochemical Expression of CD44 Isoforms in Eccrine Gland Tumors

Kim SY, Choi KC, Chung BS

  • KMID: 2303208
  • Korean J Dermatol.
  • 2000 Aug;38(8):1024-1029.
BACKGROUND: CD44 is the principal cell surface receptor for hyaluronate and exists as multiple isoforms generated by the alternative splicing of up to 10 variant exons. Although certain isofroms may...
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Diagnostic Significance of p38 Isoforms (p38α, p38β, p38γ, p38δ) in Head and Neck Squamous Cell Carcinoma: Comparative Serum Level Evaluation and Design of Novel Peptide Inhibitor Targeting the Same

Sahu V, Nigam L, Agnihotri , Gupta A, Shekhar S, Subbarao N, Bhaskar S, Dey S

PURPOSE: The p38 mitogen-activated protein kinase (MAPKs) play a crucial role in the production of pro-inflammatory cytokines and over-expression of it increase cytokines which promote cancer. Among four isoforms, p38α...
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Differential Expression of TGF-beta Isoforms During Differentiation of HaCaT Human Keratinocyte Cells: Implication for the Separate Role in Epidermal Differentiation

Cho HR, Hong SB, Kim YI, Lee JW, Kim NI

The three mammalian isoforms of transforming growth factor-beta (TGF-beta1, beta2, beta3) are potent regulators of cell growth, differentiation, and extracellular matrix deposition. To study their role in skin differentiation, we...
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A novel PRKAR1A mutation resulting in a splicing variant in a case of Carney complex

Jang YS, Moon SD, Kim JH, Lee IS, Lee JM, Kim HS

No abstract available.
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Understanding the Role of Heat Shock Protein Isoforms in Male Fertility, Aging and Apoptosis

Purandhar , Jena PK, Prajapati , Rajput P, Seshadri S

Heat shock proteins (HSPs) play a role in the homeostasis, apoptosis regulation and the maintenance of the various other physiological processes. Aging is accompanied by a decrease in the resistance...
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