- A Case of Doxifluridine-Induced Multiple Atypical Moles on the Palm and Sole of a Patient Taking Immunosuppressive Agents
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Chung WK, Kang SM, Rhee DY, Chang SE, Lee MW, Choi JH, Moon KC
- KMID: 1484235
- Korean J Dermatol.
- 2008 Sep;46(9):1257-1261.
Doxifluridine is a pyrimidine derivative and is activated to 5-fluorouracil by pyrimidine phosphorylase. Multiple acral hyperpigmented macules have been reported in patients treated with systemic 5-fluorouracil or some of its... -
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- Liposomes as Acitivators of Lipophilic Platinum (2 ) Complexes
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Han IS, Lee YJ
- KMID: 2175291
- J Korean Cancer Assoc.
- 1999 Feb;31(1):180-187.
PURPOSE: The goal of this study is to understand the activation processes that take place within the liposomal formulation of lipophilic diaminocyclohexane platinum (DACH-Pt) complexes, to identify the activated species... -
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- Chemotherapy for Advanced Gastric Cancer: Slow but Further Progress
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Kim YH
- KMID: 1571458
- Cancer Res Treat.
- 2005 Apr;37(2):79-86.
Gastric cancer remains a significant problem in terms of global health, and is the most common cancer in Korea. Surgery is the only potentially curative treatment for localized gastric cancer,... -
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- Antitunor effect of carcinoma cells transduced with herpes simplex virus - thymidine kinase by gancyclovir and radiation
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Lee JW, Oh ST, Ahn CH, Lim KW, Cho HI, Kim GR, Kim TG
- KMID: 2150556
- Immune Netw.
- 2001 Apr;1(1):45-52.
- doi: 10.4110/in.2001.1.1.45
BACKGROUND: Many types of cancer become resistant to current chemotherapeutic and radiotherapeutic intervention. To overcome this situation application of gene therapy by the introduction of suicide genes followed by their... -
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- Development of Luciferase Reporter Gene-based Cell Bioassay for the Aromatic Hydrocarbon Receptor Agonists
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Kim SY, Choi EJ, Yang JH
- KMID: 1587477
- Korean J Physiol Pharmacol.
- 2006 Dec;10(6):349-354.
The aromatic hydrocarbon receptor (AhR) is a ligand-activated transcription factor that mediates many of the biological and toxicological effects of 2,3,7,8-tetrachlorodibenzo-p-dioxin (TCDD, dioxin) and related chemicals. The application of recombinant... -
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- Effects of neural stem cells and 5-fluorocytosine in canine metastatic lung tumor
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Hwang Y, Kim D, Chang D, Ahn B, Kim YB, Kim G
- KMID: 2412580
- J Vet Sci.
- 2017 Jun;18(2):257-260.
- doi: 10.4142/jvs.2017.18.2.257
This is the first case report to describe the tumor regressive effect of systemic human neural stem cell (NSC)/5-fluorocytosine (5-FC) therapy on canine metastatic lung tumor. The therapeutic effects appeared... -
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- Psammaplin A is a natural prodrug that inhibits class I histone deacetylase
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Kim DH, Shin J, Kwon HJ
- KMID: 1103680
- Exp Mol Med.
- 2007 Feb;39(1):47-55.
Histone deacetylase (HDAC) has been highlighted as one of key players in tumorigenesis and angiogenesis. Recently, several derivatives of psammaplin (Psams) from a marine sponge have been known to inhibit... -
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- Improving Conventional or Low Dose Metronomic Chemotherapy with Targeted Antiangiogenic Drugs
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Kerbel RS
- KMID: 2166019
- Cancer Res Treat.
- 2007 Dec;39(4):150-159.
One of the most significant developments in medical oncology practice has been the approval of various antiangiogenic drugs for the treatment of a number of different malignancies. These drugs include... -
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- Overexpression of Uridine-Cytidine Kinase 2 Correlates with Breast Cancer Progression and Poor Prognosis
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Shen G, He P, Mao Y, Li P, Luh F, Ding G, Liu X, Yen Y
- KMID: 2389750
- J Breast Cancer.
- 2017 Jun;20(2):132-141.
- doi: 10.4048/jbc.2017.20.2.132
PURPOSE: Uridine-cytidine kinase (UCK) 2 is a rate-limiting enzyme involved in the salvage pathway of pyrimidine-nucleotide biosynthesis. Recent studies have shown that UCK2 is overexpressed in many types of cancer... -
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- Capecitabine and Oxaliplatin (XELOX) for the Treatment of Patients with Metastatic Gastric Cancer and Severe Liver Dysfunction
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Hwang SJ, Park JW, Lee SD, Kim GJ, Sin CH, Nam SH, Kim BS
- KMID: 759861
- Korean J Intern Med.
- 2006 Dec;21(4):252-255.
- doi: 10.3904/kjim.2006.21.4.252
Gastric cancer patients with severe liver dysfunction secondary to hepatic metastases have limited treatment options. Most cytotoxic drugs have a narrow therapeutic index. Although both capecitabine and oxaliplatin have been... -
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- Transduction of yeast cytosine deaminase mediated by HIV-1 Tat basic domain into tumor cells induces chemosensitivity to 5-fluorocytosine
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Lee H, Ryu J, Kim KA, Lee KS, Lee JY, Park JB, Park J, Choi SY
- KMID: 755664
- Exp Mol Med.
- 2004 Feb;36(1):43-51.
Enzyme/prodrug approach is one of the actively developing areas for cancer therapy. In an effort to develop more effective enzyme/prodrug systems, cell-permeable cytosine deaminase was produced by fusing yeast cytosine... -
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- Capecitabine and Vinorelbine in Patients with Metastatic Breast Cancer Previously Treated with Anthracycline and Taxane
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Ahn JH, Kim SB, Kim TW, Ahn SH, Kim SM, Park JM, Lee JS, Kang YK, Kim WK
- KMID: 2157684
- J Korean Med Sci.
- 2004 Aug;19(4):547-553.
- doi: 10.3346/jkms.2004.19.4.547
We have evaluated the efficacy and safety of the combination of capecitabine and vinorelbine in metastatic breast cancer (MBC) patients previously treated with anthracycline-and taxane-containing regimens. Between April 2000 and... -
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- Bioavailability of the amino acid-attached prodrug as a new anti-HIV agent in rats
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Chae KA, Cho HJ, Sung JM, Lee H, Seo DC, Kim JS, Shin HC
- KMID: 1090801
- J Vet Sci.
- 2007 Sep;8(3):263-267.
- doi: 10.4142/jvs.2007.8.3.263
The primary objective of this study was to compare thepharmacokinetics of a new anti-human immunodeficiencyvirus agent 1-(2-amino-pyridin-4-ylmethyl)-6-(3,5-dimethyl-benzoyl)-5-isopropyl-1H-pyrimidine-2,4-dione (VP-0502)with its amino acid prodrug alanine amide of VP-0502(VP-0502AL), following intravenous and oral... -
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- Comparison of Parecoxib and Proparacetamol in Endoscopic Nasal Surgery Patients
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Leykin Y, Casati A, Rapotec A, Dalsasso M, Barzan L, Fanelli G, Pellis T
- KMID: 724252
- Yonsei Med J.
- 2008 Jun;49(3):383-388.
- doi: 10.3349/ymj.2008.49.3.383
PURPOSE: The aim of the study was to compare the efficacy of parecoxib for postoperative analgesia after endoscopic turbinate and sinus surgery with the prodrug of acetaminophen, proparacetamol. MATERIALS AND... -
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- An antioxidant modulates expression of receptor activator of NF-kappaB in asthma
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Lee KS, Park HS, Park SJ, Kim SR, Min KH, Jin SM, Li L, Lee YC
- KMID: 1094147
- Exp Mol Med.
- 2006 Jun;38(3):217-229.
Oxidative stress plays critical roles in airway inflammation that is usually accompanied by increased vascular permeability and plasma exudation. VEGF increases vascular permeability and leads to airway inflammation. In addition,... -
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