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Negative myoclonus associated with pregabalin

Park KD, Kim MK, Lee SJ

Negative myoclonus (NM) is a jerky, shock-like involuntary movement caused by a sudden, brief interruption of muscle contraction. An 80-year-old man presented with multifocal NM and confusion. Two days before...
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A Case Report of Syndrome of Inappropriate Antidiuretic Hormone Induced by Pregabalin

Jung YJ, Lee DY, Kim HW, Park HS, Kim B

The syndrome of inappropriate antidiuretic hormone secretion (SIADH) is the most common cause of euvolemic hyponatremia, and many medications have been associated with SIADH. Pregabalin is a drug used for...
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Pharmacotherapy of Generalized Anxiety Disorder and Pregabalin

Jung YE, Chae JH

  • KMID: 2287425
  • Korean J Psychopharmacol.
  • 2008 May;19(3):136-146.
Multiple randomized, double-blind, placebo-controlled trials have explored the efficacy of pregabalin for the treatment of generalized anxiety disorder (GAD) and this novel drug was recently approved in Europe. Short-term efficacy...
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Effects of pregabalin and gabapentin on postoperative pain and opioid consumption after laparoscopic cholecystectomy

Eidy M, Fazel MR, Abdolrahimzadeh H, Moravveji , Kochaki E, Mohammadzadeh M

BACKGROUND: Gabapentin and pregabalin are antiepileptic drugs that are also used for chronic pain treatment. This study evaluated the effects of pregabalin and gabapentin on postoperative pain in patients undergoing...
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Effectiveness of Pregabalin for Treatment of Burning Mouth Syndrome

Amasyalı , Gürses AA, Aydın ON, Akyol A

Treatment of burning mouth syndrome (BMS) is challenging because there is no consensus regarding pharmalogical or nonpharmalogical therapies. The use of anticonvulsants is controversial. We present nine patients BMS who...
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The Efficacy of Preemptive Analgesia With Pregabalin in Septoplasty

Kim JH, Seo MY, Hong SD, Lee J, Chung SK, Kim HY, Dhong HJ

  • KMID: 2278382
  • Clin Exp Otorhinolaryngol.
  • 2014 Jun;7(2):102-105.
OBJECTIVES: Pregabalin is used to treat neuropathic pain and has shown analgesic properties in postoperative pain. The aim of this study was to investigate the effectiveness and safety of pregabalin...
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Effect of preoperative pregabalin on postoperative pain after gastrectomy

Park CY, Park SH, Lim DG, Choi EK

BACKGROUND: Pregabalin has been studied as a single or multimodal analgesic drug for postoperative pain management in different types of surgeries. We evaluated the analgesic effect of 150 mg of...
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Does Pregabalin Have Neuropsychotropic Effects?: A Short Perspective

Marks DM, Patkar AA, Masand PS, Pae CU

  • KMID: 2315817
  • Psychiatry Investig.
  • 2009 Jun;6(2):55-58.
Pregabalin is a newly developed synthetic gamma-aminobutyric acid (GABA) that is approved for the treatment of fibromyalgia and several neuropathy. It has been proven to show analgesic, anxiolytic, anticonvulsant and...
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The Analgesic Effects of Intrathecal Pregabalin in Rat Formalin Tests: Comparison between Pre- and Post-treatment

Cho NR, Kweon TD, Han DW, Yoon KB, Lee YW

BACKGROUND: Pregabalin is an analog of gamma aminobutyric acid, and selectively interacts with the alpha-2-delta subunit of the voltage dependent calcium channels. The aims of this study were to investigate...
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A Randomised, Placebo-controlled Trial of the Effects of Preoperative Pregabalin on Pain Intensity and Opioid Consumption following Lumbar Discectomy

Hegarty DA, Shorten GD

BACKGROUND: Pregabalin has been shown to have analgesic effect in acute pain models. The primary objective was to examine the efficacy a single dose of pregabalin, would have on morphine...
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Neuropathic Pain in Elderly Patients with Chronic Low Back Painand Effects of Pregabalin: A Preliminary Study

Sakai Y, Ito K, Hida T, Ito S, Harada A

STUDY DESIGN: Preliminary study. PURPOSE: To assess the association of neuropathic pain with chronic low back pain (LBP) and the effect of pregabalin on neuropathic pain in the elderly. OVERVIEW OF LITERATURE:...
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Low doses of amitriptyline, pregabalin, and gabapentin are preferred for management of neuropathic pain in India: is there a need for revisiting dosing recommendations?

Kamble SV, Motlekar S, D'souza LL, Kudrigikar VN, Rao SE

BACKGROUND: Current therapy for the treatment of neuropathic pain is often unsatisfactory. Considerable variation in treatment pattern still exists in spite of availability of sufficient literature from various guidelines. Recent...
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Participation of KATP Channels in the Antinociceptive Effect of Pregabalin in Rat Formalin Test

Kweon TD, Kim JY, Kwon IW, Choi JB, Lee YW

BACKGROUND: Pregabalin is an anticonvulsant and analgesic agent that interacts selectively with the voltage-sensitive-Ca(2+)-channel alpha-2-delta subunit. The aim of this study was to evaluate whether the analgesic action of intrathecal...
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Preventive Gabapentin versus Pregabalin to Decrease Postoperative Pain after Lumbar Microdiscectomy: A Randomized Controlled Trial

Qadeer M, Waqas M, Rashid MJ, Enam SA, Sharif S, Murtaza G

STUDY DESIGN: Randomized controlled trial. PURPOSE: The purpose of this study was to compare pregabalin and gabapentin for mean postoperative visual analog score (VAS) for pain in patients undergoing single-level lumbar...
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Red Scrotum Syndrome Treatment with Pregabalin: A Case Series

Cardenas-de la Garza JA, Villarreal-Villarreal CD, Cuellar-Barboza A, Cardenas-Gonzalez RE, Gonzalez-Benavides N, Cruz-Gomez LG, Ocampo-Candiani J, Welsh O

Red scrotum syndrome (RSS) (also known as male genital dysesthesia) is a rarely recognized entity characterized by scrotal erythema accompanied by a burning sensation, pain, hyperesthesia/dysesthesia, increased temperature and pruritus....
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Extrapyramidal side effects after metoclopramide administration in a post-anesthesia care unit: A case report

Jo YY, Kim YB, Yang MR, Chang YJ

Although the incidence of extrapyramidal reactions associated with metoclopramide has been reported to be approximately 0.2%, such reactions are rare in the anesthetic field. Several anesthetic adjuvants, including ondansetron and...
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Comparative Evaluation of Pregabalin and Clonidine as Preemptive Analgesics for the Attenuation of Postoperative Pain Following Thoracolumbar Spine Surgery

Bala R, Kaur J, Sharma J, Singh R

STUDY DESIGN: Prospective, randomized, double blind, placebo-controlled study. PURPOSE: To compare clonidine and pregabalin with placebo for the attenuation of postoperative pain after thoracolumbar spinal surgery and instrumentation OVERVIEW OF LITERATURE: Spine...
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Updates on the Treatment of Restless Legs Syndrome

Kang SG

Restless legs syndrome (RLS) is a sleep disorder characterized by an urge to move the legs or arms and uncomfortable paresthesia in the legs. Treatment of RLS can be various...
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Effect of oral pregabalin on opioid-induced hyperalgesia in patients undergoing laparo-endoscopic single-site urologic surgery

Lee C, Lee HW, Kim JN

BACKGROUND: Pregabalin is an antiepileptic drug that is effective for treating postoperative pain, neuropathic pain, anxiety, and hemodynamic instability. The aim of this study was to investigate the effect of...
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Evaluation of the neurological safety of epidurally-administered pregabalin in rats

Lee JR, Lee PB, Choe G, Lee SC, Lee HM, Kim E, Kim YC

BACKGROUND: The primary site of action of pregabalin, i.e. the alpha-2-delta subunit of the voltage-dependent calcium channel, is located at the dorsal root ganglion and dorsal horn of the spinal...
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