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Functions of the prefrontal cortex in the human brain

Paik E

The prefrontal cortex of the human brain is affected by various pathological conditions, and for the apparent theoretical gains and clinical benefits, brain scientists and clinicians alike have for...
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Two-channel Near-infrared Spectroscopic Analysis of Association of Paranoia Symptoms with Prefrontal Activation

Hirao K

OBJECTIVE: The relationship between paranoia symptoms and underlying prefrontal cortex mechanisms among healthy subjects was analyzed using near-infrared spectroscopy. METHODS: Seventy-eight healthy subjects were assessed for paranoia symptoms using the Japanese...
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Comparison of the Dopamine Response in the Rat Prefrontal Cortex Induced by Irregular and Regular Electrical Stimuli

Chung YC, Moon SG, Eun HB, Hwang IK, Lim CW, Han JH

  • KMID: 2037058
  • Korean J Psychopharmacol.
  • 2002 Dec;13(4):239-245.
OBJECTIVE: In general, it is known that repetitive regular stimuli induce tolerance and repetitive irregular stimuli induce sensitization. We sought to determine the dopamine response in the rat prefrontal cortex...
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Effects of Acute and Chronic Treatment of Olanzapine and Risperidone on the Extracellular Dopamine Concentrations of the Prefrontal Cortex in Rats

Moon SK, Chung YC, Eun HB, Hwang IK, Park TW

  • KMID: 2340641
  • J Korean Neuropsychiatr Assoc.
  • 2002 Jan;41(1):61-68.
OBJECT: It is reported that the effect of antipsychotics on the extracellular dopamine levels in the prefrontal cortex is related to the their effect on the negative symptoms. Therefore, we...
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Differential Changes in Neural Activity of Prefrontal Cortical Neurons of Behaving Rats by Clozapine Administration

Ha HJ, Jung MW, Han SJ, Chung YK

  • KMID: 2287344
  • Korean J Psychopharmacol.
  • 2003 Mar;14(1):28-34.
OBJECTIVE: A previous study indicated that acute treatment of clozapine increased the neural activity of prefrontal cortical neurons of anesthetized rats. This study was to investigate the effect of clozapine...
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Prefrontal Cortex and Schizophrenia

Chung YC, Eun HB

  • KMID: 2334567
  • J Korean Soc Biol Psychiatry.
  • 1998 Nov;5(2):184-196.
With a rapid development of neuroscience, the theories related to the pathophysiology of schizophrenia have been changed a lot from a simple hyperdopaminergic one to the various complicated ones. Among...
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Increased Ventrolateral Prefrontal Cortex Activation during Accurate Eyewitness Memory Retrieval: An Exploratory Functional Near-Infrared Spectroscopy Study

Ham K, Kim KP, Jeong H, Yoo SH

We investigated the neural correlates of accurate eyewitness memory retrieval using functional near-infrared spectroscopy. We analyzed oxygenated hemoglobin (HbOâ‚‚) concentration in the prefrontal cortex during eyewitness memory retrieval task and...
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The Upper Ascending Reticular Activating System between Intralaminar Thalamic Nuclei and Cerebral Cortex in the Human Brain

Jang S, Kwak S

PURPOSE: The ascending reticular activating system (ARAS) is responsible for regulation of consciousness. In this study, using diffusion tensor imaging (DTI), we attempted to reconstruct the thalamocortical projections between the...
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An Autoradiographic Study on the Rat Neostriatal Dopamine Receptor Changes after 6-hydroxydopamine Injection into the Medial Prefrontal Cortex

Kwon JS, Lee DY, Woo JI

  • KMID: 2340296
  • J Korean Neuropsychiatr Assoc.
  • 1999 Mar;38(2):408-418.
The frontal cortex of rat is innervated by dopaminergic pathway(mesocortical pathway) arising from ventral tegmental area. Several studies have suggested that mesocortical dopaminergic neurons may modulate the function of dopaminergic...
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Attention and Psychiatric disorders

Ha KS, Kang UG, Kim JH

  • KMID: 1944939
  • J Korean Soc Biol Psychiatry.
  • 1997 Jun;4(1):19-23.
Attention is a phenomenon hard to define, but can be conceptualized as a mental function ranging from sustaining readiness to perceive stimuli to understanding the nature and value and selecting...
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Prefrontal hemodynamic responses and the degree of flow experience among occupational therapy students during their performance of a cognitive task

Hirao K

PURPOSE: Although flow experience is positively associated with motivation to learn, the biological basis of flow experience is poorly understood. Accumulation of evidence on the underlying brain mechanisms related to...
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Changes in the Regional Cerebral Perfusion after Eye Movement Desensitization and Reprocessing: A SPECT Study of Two Cases

Oh DH, Choi J

  • KMID: 2248986
  • Korean J Biol Psychiatry.
  • 2004 Nov;11(2):173-180.
Over the last decade, EMDR(Eye Movement Desensitization and Reprocessing) has emerged as a promising new treatment for trauma and other anxiety-based disorders. However, neurobiological mechanism of EMDR has not been...
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Thalamocortical Connections between the Mediodorsal Nucleus of the Thalamus and Prefrontal Cortex in the Human Brain: A Diffusion Tensor Tractographic Study

Jang SH, Yeo SS

PURPOSE: The elucidation of thalamocortical connections between the mediodorsal nucleus (MD) of thalamus and the prefrontal cortex (PFC) is important in the clinical fields of neurorehabilitation and psychiatry. However, little...
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Improvement of the Working Memory and Naming by Transcranial Direct Current Stimulation

Jeon SY, Han SJ

  • KMID: 2391520
  • Ann Rehabil Med.
  • 2012 Oct;36(5):585-595.
OBJECTIVE: To investigate the effects of transcranial direct current stimulation (tDCS) applied over the prefrontal cortex on the improvement of verbal, visuospatial working memory and naming in healthy adults. METHOD: Thirty...
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Desynchronization of Theta Oscillations in Prefrontal Cortex during Self-stimulation of the Medial Forebrain Bundles in Mice

Hwang E, Lee H, Choi JH

Stimulation of the medial forebrain bundle (MFB) can reinforce intracranial self-stimulation (ICSS) in rodents (i.e., reward-seeking behavior). The MFB stimulation produces a highly reliable behavioral output that enabled a clear...
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Inactivation of the Medial Prefrontal Cortex Interferes with the Expression But Not the Acquisition of Differential Fear Conditioning in Rats

Lee YK, Choi JS

The medial prefrontal cortex (mPFC) has been implicated in the processing of emotionally significant stimuli, particularly the inhibition of inappropriate responses. We examined the role of the mPFC in regulation...
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Effect of Prefrontal Repetitive Transcranial Magnetic Stimulationon the Enhancement of Working Memory

Ohn SH, Park CI, Lee BH, Kim YH

  • KMID: 2325183
  • J Korean Acad Rehabil Med.
  • 2008 Oct;32(5):501-505.
OBJECTIVE: To investigate the effect of repetitive transcranial magnetic stimulation (rTMS) applied over the left prefrontal cortex on the enhancement of verbal working memory in healthy persons. METHOD: High frequency (10...
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Central Neural Networks of Verbal Working Memory and Visuospatial Attention: An Interference Approach Using Low-frequency Repetitive Transcranial Magnetic Stimulation

Ko MH, Seo JH, Jang SH, Yoo WK, Kim YH

  • KMID: 2324032
  • J Korean Acad Rehabil Med.
  • 2004 Aug;28(4):301-305.
OBJECTIVE: We evaluated a role of prefrontal and parietal cortex in verbal working memory and visuospatial attention using repetitive transcranial magnetic stimulation (rTMS). METHOD: In six healthy volunteers, bilateral prefrontal...
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The Effects of Repetitive Transcranial Magnetic Stimulation at Dorsolateral Prefrontal Cortex in the Treatment of Migraine Comorbid with Depression: A Retrospective Open Study

Kumar S, Singh S, Kumar N, Verma R

OBJECTIVE: The literature on managing migraine non-responsive to pharmacological approaches and that co-occurring with depression is scanty. The comorbid condition predicts a poorer prognosis for migraine as well as depression....
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Efficacy and Safety of rTMS in Treatment of Refractory Obsessive-Compulsive Disorder-An Open Trial

Lee SJ, Jung YE, Seo HJ, Chae JH

  • KMID: 2011067
  • Korean J Psychopharmacol.
  • 2009 Jul;20(4):205-211.
Objectives : Recently, several attempts have been made to use repeated transcranial magnetic stimulation (rTMS) with various stimulation frequencies as a novel treatment for patients with obsessive-compulsive disorder (OCD). However,...
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