- DNA Methylation in Brain and Liver Tissues of Mice Infected with Scrapie Agent
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Choi EK, Uyeno S, Ono T, Carp RI, Kim YS
- KMID: 1551980
- J Korean Soc Virol.
- 1998 Jun;28(2):183-192.
DNA methylation degree in the several murine brain and liver genes of different ages and after scrapie infection have been examined by using methylation-sensitive restriction endonuclease digestion. We found that... -
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- Evaluation of Infective Property of Recombinant Prion Protein Amyloids in Cultured Cells Overexpressing Cellular Prion Protein
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Kim DH, Lee HM, Ryou C
- KMID: 2069947
- J Korean Med Sci.
- 2014 Dec;29(12):1604-1609.
- doi: 10.3346/jkms.2014.29.12.1604
Misfolded isoform of prion protein (PrP), termed scrapie PrP (PrP(Sc)), tends to aggregate into various fibril forms. Previously, we reported various conditions that affect aggregation of recombinant PrP into amyloids.... -
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- Degradation of misfolded proteins in neurodegenerative diseases: therapeutic targets and strategies
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Ciechanover A, Kwon YT
- KMID: 2155412
- Exp Mol Med.
- 2015 Mar;47(3):e147.
- doi: 10.1038/emm.2014.117
Mammalian cells remove misfolded proteins using various proteolytic systems, including the ubiquitin (Ub)-proteasome system (UPS), chaperone mediated autophagy (CMA) and macroautophagy. The majority of misfolded proteins are degraded by the... -
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- Re-transmissibility of mouse-adapted ME7 scrapie strain to ovine PrP transgenic mice
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Babalola J, Kim JM, Lee YJ, Park JH, Choi HS, Choi YG, Choi EK, Kim YS
- KMID: 2454011
- J Vet Sci.
- 2019 Mar;20(2):e8.
- doi: 10.4142/jvs.2019.20.e8
Scrapie is a mammalian transmissible spongiform encephalopathy or prion disease that predominantly affects sheep and goats. Scrapie has been shown to overcome the species barrier via experimental infection of other... -
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- Immunohistochemical detection of Prion protein (PrP-Sc) and epidemiological study of BSE in Korea
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Koo HC, Park YH, Lee BC, Chae C, O'Rourke K, Baszler TV
- KMID: 1103502
- J Vet Sci.
- 2001 Apr;2(1):25-31.
Though the aetiology of transmissible spongiform encephalopathies (TSEs) remains uncertain, proteinase resistant prion protein (PrP-Sc), a converted form of the normal cellular prion protein (PrP-C), accumulates in the lysosome of... -
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