- Urokinase, urokinase receptor, and plasminogen activator inhibitor-1 expression on podocytes in immunoglobulin A glomerulonephritis
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Lee JH, Oh MH, Park JS, Na GJ, Gil HW, Yang JO, Lee EY, Hong SY
- KMID: 1792033
- Korean J Intern Med.
- 2014 Mar;29(2):176-182.
- doi: 10.3904/kjim.2014.29.2.176
BACKGROUND/AIMS: The purpose of this study was to investigate the expression of urokinase-type plasminogen activator (uPA), uPA receptor (uPAR), and plasminogen activator inhibitor (PAI)-1 on podocytes in immunoglobulin A (IgA)... -
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- Clinical significance of plasma tissue plasminogen activator and plasminogen activator inhibitor-1 in chronic stable angina
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Choi YJ, Park SS, Park SW, Sohn DW, Oh BH, Lee MM, Park YB, Choi YS, Seo JD, Lee YW
- KMID: 2229227
- Korean Circ J.
- 1993 Jun;23(3):356-362.
- doi: 10.4070/kcj.1993.23.3.356
BACKGROUND: Impaired fibrinolytic system has been considered to play an important role in the pathogenesis of coronary artery disease, especially associated with thrombus formation. To evaluate the pathogenetic role of... -
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- Plasminogen Activator Inhibitor Type 1 Gene Polymorphism in Patients with Minimal Change Nephrotic Syndrome
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Kim YM, Hong HK, Kim SD, Cho BS
- KMID: 2197650
- J Korean Soc Pediatr Nephrol.
- 2004 Apr;8(1):26-32.
PURPOSE: Hypercoagulability is present in patients with nephrotic syndrome. Plasminogen activator inhibitor type 1(PAI-1) is a major inhibitor of plasminogen activators. PAI-1 inactivates both tissue plasminogen activator(tPA) and urokinase plasminogen... -
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- Expression of Matrix Metalloproteinase and Urokinase-type Plasminogen Activator in Epithelial Tumors of the Ovary
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Min YK, Lee HJ, Park CM, Park IS
- KMID: 1979447
- Korean J Gynecol Oncol.
- 2005 Jun;16(2):104-112.
OBJECTIVE: The most important biologic characters of malignant tumor are invasion and metastasis, and extracellular matrix is first barrier in metastatic process. Therefore, proteases are linked to the malignant phenotype... -
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- Plasmin System in Placenta from Women with Normal and Preeclamptic Pregnancy
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Roh CR, Lee JH, Yoon BK
- KMID: 2261361
- Korean J Obstet Gynecol.
- 1999 Mar;42(3):539-543.
OBJECTIVES: the aim of this study was to evaluate plasmin system in placenta fiom women with normal and preeclamptic pregnancy. METHODS: The levels of urokinase-type plasminogen activator(uPA), tissue-type plasrninogen activator(tPA),... -
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- Polymorphism of Plasminogen Activator Inhibitor-1 and Development of Diabetic Renal Failure in Koreans
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Kim Y, Jin H, Sohn SS, Park B, Lee SH, Lee TW, Ihm CG, Kim MJ
- KMID: 2079446
- Korean J Nephrol.
- 2005 Mar;24(2):223-229.
BACKGROUND: An elevated plasma plasminogen activator inhibitor-1 (PAI-1) concentration has been identified as a factor for the development of macroangiopathy including myocardial infarction, and an association between polymorphism of the... -
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- Relationship between Plasminogen Activator Inhibitor-1 (PAI-1), Lipoprotein(a) and Diabetic Retinopathy in Type 2 Diabetes Mellitus
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Choi SY, Kim EY, Kim KW, Jung YY, Ho J, Ku YH, Lee HK, Kim MK
- KMID: 2177945
- J Korean Diabetes Assoc.
- 1999 Aug;23(4):552-561.
BACKGROUND: Diabetic retinopathy is a major cause of visual loss today, especially in diabetic patients having disturbances in hemostasis. Plasma plasminogen activator inhibitor-1 (PAI-1) and lipoprotein (a) may be involved... -
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- Coagulation and Fibrinolysis in Exudative Peural Effusions
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Ryu JS, Lee HL
- KMID: 2318184
- Tuberc Respir Dis.
- 1998 Dec;45(6):1214-1222.
BACKGROUND: The intrapleural hypofibrinolysis is caused by mainly excessive concentration of pleural plasminogen ogen activator inhibitor-1 antigen(PAI-1 Ag), which binds tissue type plasminogen activator. In pleural inflammation induced by sclerosing... -
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- Relationship between tissue plasminogen activator, plasminogen activator inhibitor and CT image in chronic subdural hematoma
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Lim DJ, Chung YG, Park YK, Song JH, Lee HK, Lee KC, Chu JW, Yang YS
- KMID: 644904
- J Korean Med Sci.
- 1995 Oct;10(5):373-378.
- doi: 10.3346/jkms.1995.10.5.373
The present study was performed to investigate the relationship between the concentrations of tissue-type plasminogen activator (t-PA) and plasminogen activator inhibitor (PAI) and the CT images in 23 cases of... -
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- The Difference of Thrombogenic and Fibrinolytic Factors inPremenopausal and Menopausal Women
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Park CG, Oh DJ, Seo HS, Song WH, Lim DS, Lee EM, Ahn JC, Kim YH, Shim WJ, Ro YM
- KMID: 2029438
- Korean Circ J.
- 1997 Nov;27(11):1074-1081.
- doi: 10.4070/kcj.1997.27.11.1074
BACKGROUND: Thrombotic and fibrinolytic factors which change in women following menopause, may be of pathogenetic importance in atherogenetic and thrombotic cardiovascular diseases by altering fibrinolysis on vascular surfaces. We investigated... -
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- Regulation of the Activity of Tissue Plasminogen Activator and Plasminogen Activator Inhibitor-1 by Zinc in Rat Primary Astrocytes
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Lee SY, Kim HJ, Joo SH, Kwon KJ, Lee J, Han SH, Cho JY, Cheong JH, Ko KH, Shin CY
- KMID: 2165296
- Exp Neurobiol.
- 2009 Jun;18(1):48-56.
- doi: 10.5607/en.2009.18.1.48
Tissue-type plasminogen activator (tPA) is a serine proteinase which plays important roles in functional and structural synaptic plasticity, neural migration, as well as excitotoxic injuries in several pathological situations including... -
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- Tissue Plasminogen Activator and Plasminogen Activator Inhibitor-1 Levels in Patients with Acute Paraquat Intoxication
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Seok SJ, Kim SJ, Gil HW, Yang JO, Lee EY, Hong SY
- KMID: 1777876
- J Korean Med Sci.
- 2011 Apr;26(4):474-481.
- doi: 10.3346/jkms.2011.26.4.474
To investigate the effects of reactive oxygen species (ROS) on tissue plasminogen activator (tPA) and plasminogen activator inhibitor-1 (PAI-1) plasma levels, and their possible implications on clinical outcome, we measured... -
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- Alteration of Coagulation and Fibrinolysis in Multiple Trauma
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Shin YS, Kim YJ, Park IS, Chi HS
- KMID: 2206554
- J Korean Surg Soc.
- 1999 Aug;57(2):172-179.
BACKGROUND: After multiple trauma, blood coagulation activity is enhanced and fibrinolytic activity is suppressed. Due to high tissue thromboplastin concentration in cerebral tissue, more serious coagulation and fibrinolytic abnormalities may... -
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- Expression of Matrix-Metalloproteinase-2, Urokinase-Type Plasminogen Activator and Plasminogen Activator Inhibitor-1 in Invasion Mode and Lymph Node Metastasis of Laryngeal Squamous Cell Carcinoma
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Jin SM, Lee SH, Choi G, Choi JO
- KMID: 2274480
- Korean J Otolaryngol-Head Neck Surg.
- 1998 Sep;41(9):1169-1173.
BACKGROUND AND OBJECTIVES: Metastatic process of carcinoma cells involves dissolution of tumor matrix and penetration of the basement membrane (BM) which involves the active proteolysis of type IV collagen, proteoglycan,... -
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- Increased expression of urokinase type plasminogen activator(u-PA), plasminogen activator inhibitor-1(PAI-1), and collagenases in Caco-2 cells infected by Salmonella typhimurium
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Park CG, Goh YJ, Kook SH, Park HK, Kim BJ, Cha CY, Kook YH
- KMID: 645025
- J Korean Med Sci.
- 1997 Feb;12(1):23-31.
- doi: 10.3346/jkms.1997.12.1.23
Salmonella penetrates the basement membrane of intestinal epithelial cells into deeper tissues, in which process extracellular matrix proteases should be required. Hypothesizing that the proteases might be provided by... -
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- Expression of urokinase: type plasminogen activator, its receptor, and its inhibitor in gastric adenocarcinoma tissues
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Hong SI, Park IC, Son YS, Lee SH, Kim BG, Lee JI, Lee TW, Kook YH, Min YI, Hong WS
- KMID: 932128
- J Korean Med Sci.
- 1996 Feb;11(1):33-37.
- doi: 10.3346/jkms.1996.11.1.33
The plasminogen and plasmin system, which is mainly regulated by urokinase-type plasminogen activator (uPA), its receptor (uPAR) and its inhibitor (PAI-1), is generally believed to play a role in cancer... -
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- The Relationship between Plasminogen Acti- vator Inhibitor-1 and Bone Marrow Microme- tastases in Breast Cancer
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Yoon JH, Jaegal YJ, Suh SP
- KMID: 2173604
- J Korean Breast Cancer Soc.
- 2001 Dec;4(2):192-197.
- doi: 10.4048/jkbcs.2001.4.2.192
PURPOSE: Plasminogen Activator Inhibitor-1 (PAI-1) is the principal physiological urokinase-type plasminogen activator and is thought to regulate the overall invasive and metastatic behaviors of cancer cells. Although the occurrence of... -
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- Clinical Relevance of Urokinase-type Plasminogen Activator ( uPA ) , uPA Receptor , Plasminogen Activator Inhibitor-1 Co-expression from Tissue and Serum of Breast Cancer as Targets of Biotherapy
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Rha SY, Park JO, Gong SJ, Park SH, Yoo NC, Yang WI, Roh JK, Min JS, Lee KS, Kim BS, Chung HC
- KMID: 2175221
- J Korean Cancer Assoc.
- 1999 Apr;31(2):256-266.
PURPOSE: We measured and compared the uPA, plasminogen activator inhibitor-1 (PAI-1) and uPA receptor (uPAR) levels in breast cancer tissues and blood of the patients to evaluate their clinical relevance... -
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- Association between Plasma Levels of Plasminogen Activator Inhibitor-1 and Colorectal Neoplasms
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Kim ER, Yang MH, Lim YJ, Lee JH, Chang DK, Kim YH, Son HJ, Kim JJ, Rhee JC, Kim JY
- KMID: 1806667
- Gut Liver.
- 2013 Sep;7(5):519-523.
BACKGROUND/AIMS: Plasminogen activator inhibitor-1 (PAI-1) is important for tumor growth, Invasion, and metastasis. In this study, we investigated the relationship between plasma levels of PAI-1 and colorectal adenomas. METHODS: We reviewed... -
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- The Relationship between Plasminogen Acti- vator Inhibitor-1 and Bone Marrow Microme- tastases in Breast Cancer
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Yoon JH, Jaegal YJ, Suh SP
- KMID: 2145190
- J Korean Surg Soc.
- 2001 Oct;61(4):373-378.
PURPOSE: Plasminogen Activator Inhibitor-1 (PAI-1) is the principal physiological urokinase-type plasminogen activator and is thought to regulate the overall invasive and metastatic behaviors of cancer cells. Although the occurrence of... -
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