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Photodynamic Therapy (PDT): PDT Mechanisms

Allison RR, Moghissi K

Photodynamic therapy (PDT) is a light based therapy used to ablate tumors. As practiced in oncology a photosensitizing agent is applied and then activated by a specific wavelength and energy...
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Current Status of Photodynamic Therapy for Bile Duct Cancer

Lee TY, Cheon YK, Shim CS

The most common form in bile duct cancers is a highly desmoplastic cancer with a growth pattern characterized by periductal extension and infiltration. The prognosis of bile duct cancers, especially...
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Photodynamic Therapy for Barrett's Esophagus and Esophageal Carcinoma

Qumseya BJ, David W, Wolfsen HC

This paper reviews the use of photodynamic therapy (PDT) in patients with Barrett's esophagus and esophageal carcinoma. We describe the history of PDT, mechanics, photosensitizers for PDT in patients with...
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Advance in Photosensitizers and Light Delivery for Photodynamic Therapy

Yoon I, Li JZ, Shim YK

The brief history of photodynamic therapy (PDT) research has been focused on photosensitizers (PSs) and light delivery was introduced recently. The appropriate PSs were developed from the first generation PS...
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Application of photodynamic therapy in gastrointestinal disorders: an outdated or re-emerging technique?

Lee HH, Choi MG, Hasan T

Photodynamic therapy (PDT) is a promising therapeutic modality that involves the administration of a photosensitizer followed by local illumination with a specific wavelength of light in the presence of oxygen....
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Endoscopic Ultrasound-guided Local Therapy of Pancreatic Tumors

Yoon WJ, Seo DW

The development of curvilinear EUS has enabled EUS-guided fine-needle aspiration of intra-abdominal mass lesions. With the introduction of interventional EUS, this technology has undergone several modifications in order to be...
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Antimicrobial and Antitumor Photodynamic Effects of Phleichrome from the Phytopathogenic Fungus Cladosporium Phlei

So KK, Chun J, Kim DH

Fungal perylenequinones have photodynamic activity and are promising photosensitizers for photodynamic therapy (PDT). Here, we investigated the bactericidal and antitumor activities of phleichrome from the fungal perylenequinone family in vitro....
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Gene Expression Profile of Lung Cancer Cells Following Photodynamic Therapy

Sung JH, Lee ME, Han SS, Lee SJ, Ha KS, Kim WJ

BACKGROUND: Photodynamic therapy is a viable option for lung cancer treatment, and many studies have shown that it is capable of inducing cell death in lung cancer cells. However, the...
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A Study on Photopatch Test in Photodermatoses

Jang JE, Hahm JH, Kook HI

  • KMID: 2085540
  • Korean J Dermatol.
  • 1983 Oct;21(5):531-536.
It is believed that the photopatch test is a valuable screening procedure for the determination of responsible antigenic substances in photoallergic contact dermatitis. But the technigues used for this procedure...
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Photodynamic Therapy

Jheon S

Clinical photodynamic therapy was introduced in the 1970s and has been shown to be an effective treatment modality in a variety of fields in oncology. Photodynamic therapy (PDT) is a...
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Nucleic Acid Aptamers: New Methods for Selection, Stabilization, and Application in Biomedical Science

Kong HY, Byun J

  • KMID: 2170659
  • Biomol Ther.
  • 2013 Nov;21(6):423-434.
The adoption of oligonucleotide aptamer is well on the rise, serving an ever increasing demand for versatility in biomedical field. Through the SELEX (Systematic Evolution of Ligands by EXponential enrichment),...
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Effect of Photodynamic Therapy in Lung Cancer

Yoon SH, Han KT, Kim GN, Lee SI

  • KMID: 2318501
  • Tuberc Respir Dis.
  • 2004 Oct;57(4):358-363.
BACKGROUND: Photodynamic therapy (PDT) involves the use of photosensitizing agents for treatment of malignant disease. PDT is approved by the U.S. Food and Drug Administration for the endobronchial microinvasive...
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Asymptomatic Hyperpigmentation without Preceding Inflammation as a Clinical Feature of Citrus Fruits-Induced Phytophotodermatitis

Choi JY, Hwang S, Lee SH, Oh SH

Phytophotodermatitis is a condition that occurs by contact with plants containing phototoxic agents such as furocoumarins and psoralens with subsequent ultraviolet exposure. Phytophotodermatitis typically presents as sharply defined erythematous patches...
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The anticancer effect and mechanism of photodynamic therapy using a new photosensitizer and diode laser on cervical cancer cell

Kim JS, Park CH, Chung PS

  • KMID: 2273705
  • Korean J Obstet Gynecol.
  • 2009 Apr;52(4):437-446.
OBJECTIVE: During the last several years, such as Photofrin(R), Photogem(R), HpD, and 5-aminolevulenic acid (ALA) has been used as photosensitizers for a wide range of malignant tumors as well as...
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Candida albicans test for the screening of phototoxicity in anthistamines

Kim TH

  • KMID: 2038867
  • Korean J Dermatol.
  • 1993 Apr;31(2):191-196.
BACKGROUND: Antihistamine drugs are used widely in many conditions. Although some antihistamines may cause a photosensitive reaction,many physicians are not awae of it. OBJECTIVE: For examination of the phototoxic potential of...
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Delivery of Photosensitizers for Photodynamic Therapy

Park S

  • KMID: 782862
  • Korean J Gastroenterol.
  • 2007 May;49(5):300-313.
Photodynamic therapy (PDT) has been used to treat several types of cancer, and comprises intravascular administration of photosensitizer, uptake by cancer cells, and followed by irradiation of light of appropriate...
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Experimental interstitial photodynamic therapy of the Morris 7777 hepatoma in the rat

Cheon YK, Kim YS, Cho YD, Kim YS, Lee JS, Lee MS, Shim CS, Kim BS, Jin SY

  • KMID: 1652686
  • Korean J Med.
  • 2004 Apr;66(4):397-403.
BACKGROUND: Photodynamic therapy (PDT) of hepatic tumors has been restricted due to the preferential retention of photosensitizers in normal liver tissue. Therefore, superficial tumor illumination causes subsequential liver necrosis. Moreover,...
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Therapeutic Effects of Narrow-band UVB Phototherapy in the Treatment of Vitiligo

Park SG, Lee GS, Park YK

  • KMID: 2302821
  • Korean J Dermatol.
  • 2004 Sep;42(9):1121-1129.
BACKGROUND: Recently, narrow-band UVB phototherapy is introduced for vitiligo treatment. It is easier to be applicable because of no need for topical and/or systemic photosensitizers, and comparably or more effective...
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ROS Formation and the Mechanism of Photodynamic Therapy Using 9-Hydroxypheophorbide-a on AMC-HN3 Human Head and Neck Carcinoma Cell Line

Chung PS, Park E, Lee KI, Ahn JC

  • KMID: 1593104
  • Korean J Otolaryngol-Head Neck Surg.
  • 2006 Dec;49(12):1194-1200.
BACKGROUND AND OBJECTIVES: During PDT, photosensitizer accumulates in the cell and irradiation forms ROS. ROS leads to activation of apoptoticpathway and cell death. Elevated intracellular calcium is known to play...
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Usefulness of 5-aminolevulinic acid-photodynamic for diagnosing lung cancer

Yoon SH, Lee SI, Kwon YE

  • KMID: 2257149
  • Korean J Med.
  • 2009 Nov;77(5):576-581.
BACKGROUNDS/AIMS: Photodynamic diagnosis (PDD) is a modern method for fluorescence imaging of a bronchogenic malignancy. Adverse effects and high costs, partly related to the general application of photosensitizers, are important...
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