- Phospholipase D is involved in oxidative stress-induced migration of vascular smooth muscle cells via tyrosine phosphorylation and protein kinase C
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Kim J, Min G, Bae YS, Min DS
- KMID: 1380203
- Exp Mol Med.
- 2004 Apr;36(2):103-109.
Oxidative stress has been implicated in mediation of vascular disorders. In the presence of vanadate, H2O2 induced tyrosine phosphorylation of PLD1, protein kinase C-a (PKC-a), and other unidentified proteins in... -
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- Regulation of chicken protein tyrosine phosphatase 1 and human protein tyrosine phosphatase 1B activity by casein kinase II- and p56lck-mediated phosphorylation
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Kang KR, Kim CW
- KMID: 927134
- Exp Mol Med.
- 2000 Mar;32(1):47-51.
Protein tyrosine phosphorylation and dephosphorylation are important in the regulation of cell proliferation and signaling cascade. In order to examine whether phosphatase activity of CPTP1 and HPTP1B, typical nontransmembrane protein... -
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- Afatinib Reduces STAT6 Signaling of Host ARPE-19 Cells Infected with Toxoplasma gondii
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Yang Z, Ahn HJ, Park YH, Nam HW
- KMID: 2374014
- Korean J Parasitol.
- 2016 Feb;54(1):31-38.
- doi: 10.3347/kjp.2016.54.1.31
Specific gene expressions of host cells by spontaneous STAT6 phosphorylation are major strategy for the survival of intracellular Toxoplasma gondii against parasiticidal events through STAT1 phosphorylation by infection provoked IFN-γ.... -
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- Duration and Magnitude of Extracellular Signal-Regulated Protein Kinase Phosphorylation Determine Adipogenesis or Osteogenesis in Human Bone Marrow-Derived Stem Cells
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Jung HS, Kim YH, Lee JW
- KMID: 1106452
- Yonsei Med J.
- 2011 Jan;52(1):165-172.
- doi: 10.3349/ymj.2011.52.1.165
PURPOSE: Imbalances between osteogenic and adipogenic differentiation leads to diseases such as osteoporosis. The aim of our study was to demonstrate the differences in extracellular signal-regulated kinase (ERK) phosphorylation during... -
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- A double point mutation in PCL-gamma1 (Y509A/F510A) enhances Y783 phosphorylation and inositol phospholipid-hydrolyzing activity upon EGF stimulation
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Chung SH, Kim SK, Kim JK, Yang YR, Suh PG, Chang JS
- KMID: 946654
- Exp Mol Med.
- 2010 Mar;42(3):216-222.
- doi: 10.3858/emm.2010.42.3.023
Growth factor stimulation induces Y783 phosphorylation of phosphoinositide-specific PLC-gamma1, and the subsequent activation of this enzyme in a cellular signaling cascade. Previously, we showed that a double point mutation, Y509A/F510A,... -
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- Phosphorylation of 46-kappa Da protein of synaptic vesicle membranes is stimulated by GTP and Ca2+/calmodulin
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Kim AR, Choi WH, Lee SR, Kim JS, Jeon CY, Kim JI, Kim JB, Lee JY, Kim EG, Park JB
- KMID: 1121097
- Exp Mol Med.
- 2002 Dec;34(6):434-443.
The release of neurotransmitter is regulated in the processes of membrane docking and membrane fusion between synaptic vesicles and presynaptic plasma membranes. Synaptic vesicles contain a diverse set of... -
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- Synergistic Effect of Interleukin-6 and Hyaluronic Acid on Cell Migration and ERK Activation in Human Keratinocytes
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Choi JH, Jun JH, Kim JH, Sung HJ, Lee JH
- KMID: 2151415
- J Korean Med Sci.
- 2014 Nov;29(Suppl 3):S210-S216.
- doi: 10.3346/jkms.2014.29.S3.S210
Wound healing is initiated and progressed by complex integrated process of cellular, physiologic, and biochemical events, such as inflammation, cell migration and proliferation. Interleukin 6 (IL-6) is a multifunctional cytokine,... -
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- Involvement of ROS and JNK1 in selenite-induced a poptosisin Chang liver cells
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Kim YS, Jhon DY, Lee KY
- KMID: 1380210
- Exp Mol Med.
- 2004 Apr;36(2):157-164.
Selenium is a dietary essential trace nutrient with important biological roles. Selenocompounds were reported to induce apoptosis in many types of tumor cells. In this study, we investigated the signaling... -
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- Syringaresinol causes vasorelaxation by elevating nitric oxide production through the phosphorylation and dimerization of endothelial nitric oxide synthase
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Chung BH, Kim S, Kim JD, Lee JJ, Baek YY, Jeoung D, Lee H, Choe J, Ha KS, Won MH, Kwon YG, Kim YM
- KMID: 1245262
- Exp Mol Med.
- 2012 Mar;44(3):191-201.
- doi: 10.3858/emm.2012.44.3.014
Nitric oxide (NO) produced by endothelial NO synthase (eNOS) plays an important role in vascular functions, including vasorelaxation. We here investigated the pharmacological effect of the natural product syringaresinol on... -
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- Differential effects of Fas cross-linking on phospholipase D activation and related lipid metabolism in Fas-resistant A20 cells.
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Lim SY, Lee SC, Shin IC, Han JS
- KMID: 1380228
- Exp Mol Med.
- 2002 Jul;34(3):201-210.
A20 murine lymphoma cells undergoing Fas-mediated apoptosis showed increase in the activity of phospholipase D (PLD), which is involved in proliferative or mitogenic cellular responses. Using A20 cell lines that... -
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- Aristolochia manshuriensis Kom ethyl acetate extract protects against high-fat diet-induced non-alcoholic steatohepatitis by regulating kinase phosphorylation in mouse
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Kwak DH, Kim JS, Chang KT, Choo YK
- KMID: 2413126
- J Vet Sci.
- 2016 Sep;17(3):279-287.
- doi: 10.4142/jvs.2016.17.3.279
Aristolochia manshuriensis Kom (AMK) is an herb used as a traditional medicine; however, it causes side effects such as nephrotoxicity and carcinogenicity. Nevertheless, AMK can be applied in specific ways... -
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- Molecular mechanisms involved in human platelet aggregation by synergistic interaction of platelet-activating factor and 5-hydroxytryptamine.
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Shah BH, Rasheed H, Rahman IH, Shariff AH, Khan FL, Rahman HB, Hanif S, Saeed SA
- KMID: 1457534
- Exp Mol Med.
- 2001 Dec;33(4):226-233.
Our recent studies have shown that co-activation of Gq and Gi proteins by 5-hydroxytryptamine (5-HT) and adrenaline show synergism in human platelet aggregation. This study was conducted to examine the... -
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- Agmatine Attenuates Brain Edema and Apoptotic Cell Death after Traumatic Brain Injury
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Kim JY, Lee YW, Kim JH, Lee WT, Park KA, Lee JE
- KMID: 2164481
- J Korean Med Sci.
- 2015 Jul;30(7):943-952.
- doi: 10.3346/jkms.2015.30.7.943
Traumatic brain injury (TBI) is associated with poor neurological outcome, including necrosis and brain edema. In this study, we investigated whether agmatine treatment reduces edema and apoptotic cell death after... -
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- Phosphorylation of phospholipase D1 and the modulation of its interaction with RhoA by cAMP-dependent protein kinase
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Jang MJ, Lee MJ, Park HY, Bae YS, Min DS, Ryu SH, Kwak JY
- KMID: 1380212
- Exp Mol Med.
- 2004 Apr;36(2):172-178.
Agents that elevate cellular cAMP are known to inhibit the activation of phospholipase D (PLD). We investigated whether PLD can be phosphorylated by cAMP-dependent protein kinase (PKA) and PKA-mediated phosphorylation... -
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- Tolfenamic Acid Inhibits the Proliferation, Migration, and Invasion of Nasopharyngeal Carcinoma: Involvement of p38-Mediated Down-Regulation of Slug
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Jittreetat T, Shin YS, Hwang HS, Lee BS, Kim YS, Sannikorn , Kim CH
- KMID: 2374076
- Yonsei Med J.
- 2016 May;57(3):588-598.
- doi: 10.3349/ymj.2016.57.3.588
PURPOSE: Tolfenamic acid (TA), a non-steroidal anti-inflammatory drug, is known to exhibit antitumor effects in various cancers apart from nasopharyngeal cancer (NPC). NPC exhibits high invasiveness, as well as metastatic... -
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- Dendroaspis natriuretic peptide regulates the cardiac L-type Ca2+ channel activity by the phosphorylation of alpha1c proteins
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Park SA, Kim TG, Han MK, Ha KC, Kim SZ, Kwak YG
- KMID: 1383798
- Exp Mol Med.
- 2012 Jun;44(6):363-368.
Dendroaspis natriuretic peptide (DNP), a new member of the natriuretic peptide family, is structurally similar to atrial, brain, and C-type natriuretic peptides. However, the effects of DNP on the cardiac... -
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- Hypoxia activates signal transducers and activators of transcription 5 (STAT5) and increases its binding activity to the GAS element in mammary epithelial cells
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Joung YH, Park JH, Park T, Lee CS, Kim OH, Ye SK, Yang UM, Lee KJ, Yang YM
- KMID: 1093606
- Exp Mol Med.
- 2003 Oct;35(5):350-357.
STATs (signal transducers and activators of transcription) are proteins with dual functions: signal transducers in the cytoplasm and transcriptional activators in the nucleus. STAT proteins act as transcription factors activated... -
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- CD98 activation increases surface expression and clusteringof beta 1 integrins in MCF-7 cells through FAK/Src- and cytoskeleton-independent mechanisms
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Kim SM, Hahn JH
- KMID: 756327
- Exp Mol Med.
- 2008 Jun;40(3):261-270.
- doi: 10.3858/emm.2008.40.3.261
CD98, a disulfide-linked 125-kDa heterodimeric type II transmembrane glycoprotein, regulates beta 1 integrin- mediated cell adhesion. However, the molecular mechanisms underlying CD98-mediated activation of beta 1 integrin are presently unclear.... -
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- Epigallocatechin-3-gallate inhibits paracrine and autocrine hepatocyte growth factor/scatter factor-induced tumor cell migration and invasion
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Kwak IH, Shin YH, Kim M, Cha HY, Nam HJ, Lee BS, Chaudhary , Pai KS, Lee JH
- KMID: 1097268
- Exp Mol Med.
- 2011 Feb;43(2):111-120.
- doi: 10.3858/emm.2011.43.2.013
Aberrant activation of hepatocyte growth factor/scatter factor (HGF/SF) and its receptor, Met, is involved in the development and progression of many human cancers. In the cell-based screening assay, (-)epigallocatechin-3-gallate (EGCG)... -
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- Prostaglandin E2 stimulates angiogenesis by activating the nitric oxide/cGMP pathway in human umbilical vein endothelial cells
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Namkoong S, Lee SJ, Kim CK, Kim YM, Chung HT, Lee H, Han JA, Ha KS, Kwon YG, Kim YM
- KMID: 1116204
- Exp Mol Med.
- 2005 Dec;37(6):588-600.
Prostaglandin E2(PGE2), a major product of cyclooxygenase, has been implicated in modulating angiogenesis, vascular function, and inflammatory processes, but the underlying mechanism is not clearly elucidated. We here investigated the... -
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