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Pharmacogenetics of anesthetics

Kim KM

Genetic and/or environmental factors lead to large inter-individual variability in the efficacy and the side effects of drugs. Pharmacogenetics is the study of genetically determined differences in drug response. It...
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Pharmacogenetics of asthma in children

Kondo N, Matsui E, Nishimura , Kaneko H

Allergic diseases such as bronchial asthma and atopic dermatitis develop by a combination of genetic and environmental factors. Several candidate causative genes of asthma and atopy have been reported as...
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Pharmacogenetics and Antiepileptic Drugs

Kim MK

  • KMID: 2181950
  • J Korean Epilepsy Soc.
  • 2003 Dec;7(2):96-100.
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Pharmacogenetics of Intravenous Anesthetics

Kim KM

  • KMID: 1804758
  • Anesth Pain Med.
  • 2006 Jul;1(1):1-7.
No abstract available
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Opioid pharmacogenetics in anesthesia and pain management

Kim KM

Opioids are the cornerstone for treating moderate to severe pain and are commonly used for anesthesia and pain management. However, large inter-individual variability exists in the analgesic and adverse effects....
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Severe Refractory Asthma and Genetics

Koh YI

  • KMID: 2264560
  • Korean J Med.
  • 2012 Oct;83(4):430-437.
Asthma is multifactorial complex disorder originated from genetic and environmental factors. Some genetic variants or alleles have been known to be associated with the presence or development of asthma. Gene...
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Risk Assessment and Pharmacogenetics in Molecular and Genomic Epidemiology

Park SK, Choi JY

In this article, we reviewed the literature on risk assessment (RA) models with and without molecular genomic markers and the current utility of the markers in the pharmacogenetic field. Epidemiological...
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Prediction of response in chemotherapy and molecular targeted therapy using pharmacogenetics and positron emission tomography

Kim HS, Kim JW

  • KMID: 2273517
  • Korean J Obstet Gynecol.
  • 2008 Nov;51(11):1221-1238.
Standard treatment of cancer is composed of surgery, radiation therapy and chemotherapy. Although the standard treatment has been available till now, there has been no marked decrease in the incidence...
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The Mechanisms of Atypical Antipsychotics-Induced Weight Gain and Related Pharmacogenetics

Lee JN, Yang BH

  • KMID: 2025724
  • J Korean Soc Biol Psychiatry.
  • 2003 Jun;10(1):3-19.
The use of atypical antipsychotics is limited by occurrence of adverse reactions such as weight gain, despite of their benefits. This article provides a comprehensive review and discussion of the...
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The Role of Genetics in Predictive and Personalized Medicine of Rheumatoid Arthritis

Lee HS

Recent progress of genetics has dramatically improved pharmacogenetics for human diseases. Several pharmacogenetic assays such as TPMT/azathioprine and CYP2C9/VKORC1/warfarin have been introduced in clinical practice at the present time. Rheumatoid...
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Postoperative nausea and vomiting

Moon YE

Postoperative nausea and vomiting (PONV) is a long-standing issue, not a new concept in anesthesiology. Despite many studies over the last several decades, PONV remains a significant problem due to...
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Recommendations for Optimizing Tuberculosis Treatment: Therapeutic Drug Monitoring, Pharmacogenetics, and Nutritional Status Considerations

Choi R, Jeong BH, Koh WJ, Lee SY

Although tuberculosis is largely a curable disease, it remains a major cause of morbidity and mortality worldwide. Although the standard 6-month treatment regimen is highly effective for drug-susceptible tuberculosis, the...
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Tailored Pharmacotherapy of Psychotropic Drugs

Chung IW, Lee KY

  • KMID: 1615401
  • Korean J Psychopharmacol.
  • 2002 Sep;13(3):141-147.
The pharmacotherapeutic responses such as clinical efficacy and adverse events exhibit wide variabilities in individuals and even in different races and populations. The human genetic diversity has been known as...
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Pharmacogenomics of Antipsychotic Drugs

Kim CY, Joo YH

  • KMID: 1985325
  • Korean J Psychopharmacol.
  • 2002 Jun;13(2):85-94.
There is a substantial variation in the treatment response and adverse reactions to antipsychotic drugs. Pharmacogenomics of antipsychotic drugs is to identify the gene(s) related with this variability in outcome...
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Genetic Signatures of Asthma Exacerbation

Park HW, Tantisira

Asthma exacerbation (AE) usually denotes worsening of asthma symptoms that requires intense management to prevent further deterioration. AE has been reported to correlate with clinical and demographic factors, such as...
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Brain-Derived Neurotrophic Factor(BDNF) Genetic Polymorphism and the Long-term Outcome of Antidepressant Treatment in Korean Depressive Patients

Koo JW, Lee HY, Paik JW, Kang RH, Lee MS

  • KMID: 1511824
  • Korean J Biol Psychiatry.
  • 2006 Aug;13(3):162-169.
associated with the long-term outcome of the antidepressant treatment. However, further studies with another BDNF polymorphism should be needed.
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Pharmacogenomics in Functional Gastrointestinal Disorders

Park MI

  • KMID: 2307485
  • Korean J Neurogastroenterol Motil.
  • 2006 Dec;12(2):102-107.
No abstract available.
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Pharmacogenetics and Depression: A Critical Perspective

Corponi F, Fabbri C, Serretti A

Depression leads the higher personal and socio-economical burden within psychiatric disorders. Despite the fact that over 40 antidepressants (ADs) are available, suboptimal response still poses a major challenge and is...
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Respiratory Reviews in Asthma 2013

Kim TH

  • KMID: 2320491
  • Tuberc Respir Dis.
  • 2014 Mar;76(3):105-113.
From January 2012 up until March 2013, many articles with huge clinical importance in asthma were published based on large numbered clinical trials or meta-analysis. The main subjects of these...
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Systems biology approaches in asthma pharmacogenomics study

Park HW

The response to drug treatment in asthma is a complex trait and is markedly variable even in patients with apparently similar clinical features. Pharmacogenomics is a study of variations of...
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